Which of these epigenetic changes could lead to reduced transcription of a particular gene? Please make sure to select all correct answer options. increasing acetylation of histones associated with the nucleosomes of that gene inducing histone modifications that allow the formation of denser nucleosomes in the regulatory region of the gene removing histones to expose the enhancer and promoter DNA of the gene repositioning the nucleosomes associated to the gene to expose the enhancer and promoter DNA of the gene decreasing acetylation of histones associated with the nucleosomes of that gene

Choose the statement that correctly characterizes regulated and/or constitutive gene expression. Regulated expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is either on or off, depending on the physiological or metabolic status of the cell. Constitutive expression refers to gene expression that is always repressed in response to the absence of required nutrients or other metabolic molecules. Regulated expression refers to gene expression that is always on, regardless of the metabolic or physiological conditions in the cell. Regulated and constitutive expression are terms used to describe gene expression in prokaryotes only.

Possible genetic modifications that can cause epigenetic changes in gene expression include: A- all answers are correct B- histone acetylation C- chromatin remodeling D- histone variant localization  e- DNA methylation

How can you envision using this new information? Discuss how things that we do to our bodies (smoking, recreational drugs, employment environments, stress levels, eating/drinking habits, etc.) can influence genetic expression in our future child(ren).

The chemical carcinogen dimethybenzialanthracene (DMBA) must be an extraordinarily specific mutagen since 90% of the skin tumors it causes have an A-to-Talteration at exactly the same site in the mutant Ras gene is true or false

Can you please help with 1a,1b, and 1c please 1a. Find a paper published in a scientific journal between January 2018 and September 2022 that addresses the role of an example of histone modification in affecting expression of a gene by altering histone acetylation/chromatin state of the DNA encoding that gene. What organism and/or cell type did the authors do their study in?  1b. Which histone(s) were affected by the acetylation and/or deacetylation?       What gene did they show had altered expression levels in response to the change in histone acetylation? 1c. what effect did the histone modification they studied have on that gene's level of expression - was expression of the gene they examined increased or decreased?

If we knock out a gene, it can tell us something about how important that gene is or if other genes can compensate for its absence in a complex. To further establish the role of PSEN1 and PSEN2 in early onset Alzheimer's disease they are individually knocked out in mouse models. Knockout of PSEN1 leads to an embryonic lethal phenotype and dramatically reduced Aß levels. However knockout of PSEN2 gives no obvious phenotype and essentially normal AB levels. Question 16) Which of the following hypotheses does this observation support? [10 Marks] Under normal circumstances y-secretase complexes contain equal ratios of PSEN1 and PSEN2 b. The knockout of PSEN1 and PSEN2 didn't work O c. a. Under normal circumstances y-secretase complexes primarily contain PSEN2 rather than PSEN1 d. Under normal circumstances y-secretase complexes primarily contain PSEN1 rather than PSEN2 e. Under normal circumstances y-secretase complexes do not contain either PSEN1 or PSEN2

Are all of your genes expressed in every cell in your body?  Explain your answer and include an example in your explanation.