Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 10.2, Problem 2COMQ
Negative supercoiling may enhance activities like transcription and
a. allows the binding of proteins to the major groove.
b. promotes DNA strand separation.
c. makes the DNA more compact.
d. causes all of the above.
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In nucleotide excision repair in E. coli, the function of the UvrA/UvrB complex is toa. detect DNA damage.b. make cuts on both sides of the damage.c. remove the damaged piece of DNA.d. replace the damaged DNA with undamaged DNA.
Xeroderma pigmentosa (XP):
A. is caused by a defect in the mismatch repair system.
B. typically results in base substitution mutations.
C. can be caused by defects in any of a number of different genes that have to do with DNA repair.
D. results when an individual does not spend enough time outside.
E. Can be corrected by a direct repair mechanism
The function of DNA ligase is to:
a. Catalyze formation of phosphodiester bonds between adjacent nucleotides
b. Catalyze formation of hydrogen bonds between adjacent nucleotides
c. Keep single strands of DNA apart during replication
d. Facilitate base pairing between single stranded molecules in DNA
e. Both a. and d. are correct
Chapter 10 Solutions
Genetics: Analysis and Principles
Ch. 10.1 - 1. A bacterial chromosome typically contains
a. a...Ch. 10.2 - Mechanisms that make the bacterial chromosome more...Ch. 10.2 - 2. Negative supercoiling may enhance activities...Ch. 10.2 - 3. DNA gyrase
a. promotes negative supercoiling....Ch. 10.3 - 1. The chromosomes of eukaryotes typically contain...Ch. 10.4 - Which of the following is an example of a...Ch. 10.5 - What are the components of a single nucleosome? a....Ch. 10.5 - 2. In Noll’s experiment to test the...Ch. 10.5 - Prob. 3COMQCh. 10.5 - Prob. 4COMQ
Ch. 10.6 - Prob. 1COMQCh. 10.6 - 2. The role of cohesin is to
a. make chromosomes...Ch. 10 - Prob. 1CONQCh. 10 - Prob. 2CONQCh. 10 - 3. Describe the mechanisms by which bacterial DNA...Ch. 10 - Why is DNA supercoiling called supercoiling rather...Ch. 10 - Prob. 5CONQCh. 10 - Prob. 6CONQCh. 10 - Prob. 7CONQCh. 10 - Prob. 8CONQCh. 10 - Prob. 9CONQCh. 10 - 10. What is the function of a centromere? At what...Ch. 10 - Prob. 11CONQCh. 10 - 12. Describe the structures of a nucleosome and a...Ch. 10 - Beginning with the G1 phase of the cell cycle,...Ch. 10 - Draw a picture depicting the binding between the...Ch. 10 - 15. Compare heterochromatin and euchromatin. What...Ch. 10 - 16. Compare the structure and cell localization of...Ch. 10 - 17. What types of genetic activities occur during...Ch. 10 - Lets assume the linker region of DNA averages 54bp...Ch. 10 - 19. In Figure 10.12, what are we looking at in...Ch. 10 - 20. What are the roles of the core histone...Ch. 10 - A typical eukaryotic chromosome found in humans...Ch. 10 - Which of the following terms should not be used to...Ch. 10 - Discuss the differences between the compaction...Ch. 10 - 24. What is an SMC complex? Describe two...Ch. 10 - Two circular DNA molecules, which we can call...Ch. 10 - 2. Let’s suppose you have isolated DNA from a cell...Ch. 10 - 3. We seem to know more about the structure of...Ch. 10 - In Nolls experiment of Figure 10.11, explain where...Ch. 10 - When chromatin is treated with a salt solution of...Ch. 10 - 6. Let’s suppose you have isolated chromatin from...Ch. 10 - If you were given a sample of chromosomal DNA and...Ch. 10 - Consider how histone proteins bind to DNA and then...Ch. 10 - In Chapter 23, the technique of fluorescence in...Ch. 10 - Bacterial and eukaryotic chromosomes are very...Ch. 10 - The prevalence of highly repetitive sequences...Ch. 10 - Discuss and make a list of the similarities and...
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- In an EMSA, the binding of a protein to DNAa. prevents the DNA from being digested with a restrictionenzyme.b. causes the DNA to migrate more slowly through a gel.c. causes the DNA to migrate more quickly through a gel.d. inhibits the expression of any genes within the DNA.arrow_forwardDuring DNA replication, DNA methylation: please explain answer a. A and C b. B. marks the strand not cut in mismatch repair c. A and B d. A. marks the parental DNA strand e. C. marks the strand cut in mismatch repairarrow_forwardA.) There is no change in the DNA sequence if nucleotides are added or removed, it will have no effect to the cell. B.) Mutations in the DNA sequence are all irreversible. A. Statement A is correct B. Statement B is correct C. Both A and B are correct D. Both A and B are incorrectarrow_forward
- One of the mechanisms that leads to the DNA mutations is a process known as DNA polymerase slippage which occurs during DNA replication. Which of the following statements about DNA polymerase slippage is correct? A. Backward slippage in the newly synthesized strand will lead to an insertion mutation. B. DNA polymerase slippage can lead to a point or substitution mutation. C. Forward slippage in the template strand will lead to an insertion mutation. D. All of the abovearrow_forwardThe problem of synthesizing the lagging strand, in the sense that DNA synthesis can only occur in one direction, is manifested inA. creation of primers every so often as more of the template strand isuntwisted.B. formation of shorter DNA strands called Okazaki fragments.C. the need for the enzyme ligase to link short DNA strands together.D. All of the above choices are correct.arrow_forwardTopoisomerases are enzymes that can: a. join two DNA fragments to become one. b. catalyze conformational change of a protein. c. cut DNA at specific site. d. catalyze the breaking and rejoining of DNA strands which produces DNA that is either more or less superhelical than the original.arrow_forward
- Which of the following statements describe reversal of DNA repair mechanism. A. UV light blocks the translation of mRNA beyond the damaged area B. Reversal of DNA repair mechanism requires a DNA template C. UV light is needed to initiate the formation of pyrimidine dimers D. None of the statement is correctarrow_forwardWhich of the following statements about coding strands of a gene is false? a. The sequence of the coding strand is complementary to the primary transcript. b. The sequence of the coding strand is complementary to the template strand. c. The coding strand may be on either strand of a given chromosome. d. All of the above are true about the coding strand.arrow_forwardStrand invasion is often used to repair which of the following damages to DNA? a. Single-strand breaks b. Double-strand breaks. c. Mismatched bases d. Thymine dimers.arrow_forward
- Which of the following mechanisms is involved in double-strand DNA repair? a. Homology-dependent repair b. Nonhomologous end joining c. Mismatch repair d. A and B e. A, B, and Carrow_forwardThe BRCA genes produce DNA repair proteins. Genetic testing is available that can determine if a person has a mutation in the BRCA genes that makes the proteins less able to function. What is the result of a BRCA mutation? A. The person is more likely to develop cancer if other DNA in the cell mutates. O B. The person is less likely to develop cancer unless the BRCA region is methylated. O C. The person is less likely to develop cancer because the BCA gene will inhibit the cell cycle checkpoints. D. The person is more likely to develop cancer because the BRCA gene promotes an increased rate for mitosis. swered MacBool F1 F2 F3 D00 F4 F5 F6 F7 F8 $ % & * 2 云 # 3arrow_forwardWhich of the following are strategies used by stem cells to reduce risk of alterations in their genomes and cancer (select all that apply)? A. Divide frequently so mutations during replication are diluted out B. Express high levels of xenobiotic transporters to pump exogenous chemical out of cells C. During replication, stem cells keep newly replicated strand while transit cells keep template copy D. Activate apoptosis pathways rather than DNA repair pathways when undergo DNA damage E. Located in tissue sites with minimal exposure to exogenous chemicalsarrow_forward
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