Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 8, Problem 28RQ
Summary Introduction
To determine: The reasons due to which sodium channels get closed when the neurons are maximally depolarized.
Introduction: Sodium channels are voltage-gated channels that open against a specific electrical response. Neurons can be hyperpolarized or depolarize on the movement of different ions inside and outside of the cell.
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If the response time of activation gates of both voltage gated sodium and potassium channels are same once induced by changes in membrane potential, what do you think will happen to generation of action potential when a strong (25 mV) graded potential reaches to axon hillock? Justify your answer with specific reasoning.
thanks a lot in advance:)
After an action potential has been initiated, there are two processes that prevent the membrane from remaining depolarized forever. What are these two
processes?
activation of ligand-gated channels
activation of the Na/K pump
activation of voltage-gated K+ channels
activation of voltage-gated Na+ channels
inactivation of ligand-gated channels
inactivation of the Na/K pump
inactivation of voltage-gated K+ channels
inactivation of voltage-gated Na+ channels
What are THREE major functional characteristics of the voltage-gate Na+-channels and how do these characteristics contribute to the generation of action potential?
Chapter 8 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 8.1 - Organize the following terms describing functional...Ch. 8.2 - Where do neurohormone-secreting neurons terminate?Ch. 8.2 - What is the difference between a nerve and a...Ch. 8.2 - Draw a chain of three neurons that synapse on one...Ch. 8.2 - What is the primary function of each of the...Ch. 8.2 - Name the two glial cell types that form myelin....Ch. 8.3 - Given the values in Table 8.2, use the Nernst...Ch. 8.3 - Would a cell with a resting membrane potential of...Ch. 8.3 - Would the cell membrane depolarize or...Ch. 8.3 - Match each ions movement with the type of graded...
Ch. 8.3 - Prob. 11CCCh. 8.3 - What is the difference between conductance and...Ch. 8.3 - If you put ouabain, an inhibitor of the Na+-K+...Ch. 8.3 - The pyrethrin insecticides, derived from...Ch. 8.3 - When Na+ channel gates are resetting, is the...Ch. 8.3 - A stimulating electrode placed halfway down an...Ch. 8.3 - Place the following neurons in order of their...Ch. 8.4 - Prob. 18CCCh. 8.4 - Prob. 19CCCh. 8.4 - Prob. 20CCCh. 8.4 - Prob. 21CCCh. 8.4 - Prob. 22CCCh. 8.4 - Classify the H+-neurotransmitter exchange as...Ch. 8.4 - Prob. 24CCCh. 8.4 - Prob. 25CCCh. 8.4 - Is Na+-dependent neurotransmitter reuptake...Ch. 8.5 - In Figure 8.24e, assume the postsynaptic neuron...Ch. 8.5 - In the graphs of Figure 8.24a, b, why doesnt the...Ch. 8.5 - Prob. 29CCCh. 8.5 - Prob. 30CCCh. 8 - List the three functional classes of neurons, and...Ch. 8 - Somatic motor neurons control __________, and...Ch. 8 - Prob. 3RQCh. 8 - Prob. 4RQCh. 8 - Prob. 5RQCh. 8 - Prob. 6RQCh. 8 - Axonal transport refers to the (a) release of...Ch. 8 - Match the numbers of the appropriate...Ch. 8 - Arrange the following events in the proper...Ch. 8 - List the four major types of ion channels found in...Ch. 8 - Prob. 11RQCh. 8 - An action potential is (circle all correct...Ch. 8 - Choose from the following ions to fill in the...Ch. 8 - What is the myelin sheath?Ch. 8 - List two factors that enhance conduction speed.Ch. 8 - Prob. 16RQCh. 8 - Draw and label a graph of an action potential....Ch. 8 - Prob. 18RQCh. 8 - Prob. 19RQCh. 8 - Create a map showing the organization of the...Ch. 8 - Prob. 21RQCh. 8 - Prob. 22RQCh. 8 - Prob. 23RQCh. 8 - Prob. 24RQCh. 8 - The presence of myelin allows an axon to (choose...Ch. 8 - Define, compare, and contrast the following...Ch. 8 - Prob. 27RQCh. 8 - Prob. 28RQCh. 8 - Prob. 29RQCh. 8 - Prob. 30RQCh. 8 - An unmyelinated axon has a much greater...Ch. 8 - The GHK equation is sometimes abbreviated to...Ch. 8 - In each of the following scenarios, will an action...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.arrow_forwardWhy does neuronal function require the voltage-gated K+ channels to open moreslowly than the voltage-gated Na+ channels and how would you expect the voltage-gated K+ channels to affect the shape of an action potential curve?arrow_forwardWhat happens to Na+ when a neuron is stimulated on its dendrite? Why does the movement of Na+ raise the voltage on the plasma membrane?arrow_forward
- If the response time of activation gates of both voltage gated sodium and potassium channels are same once induced by changes in membrane potential, what do you think will happen to generation of action potential when a strong (25 mV) graded potential reaches to axon hillock? Justify your answer with specific reasoning.arrow_forwardAt the peak of the neuronal action potential, Vm is approximately +50 mV. Assuming normal intracellular and extracellular K+ concentrations ( [K+]o = 4 mM, [K+]i = 150 mM ), what is the driving force (in mV) that acts on K+ ions at the peak of the action potential?arrow_forwardWhen an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?arrow_forward
- You generate action potentials in a neuron bathed in solution in a petri dish by applying a threshold-level depolarizing stimulus near its axon hillock. If the solution surrounding the neuron contained 5mM K+, 150 mM Na+, and 0 mM Ca2+ which of the following would you expect? The neuron would not be able to propagate action potentials down the entire length of the axon The neuron would not release neurotransmitter from the axon terminal The neurons action potentials would have an unusually long duration The neuron would have a resting membrane potential of zeroarrow_forwardIn the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential. Discuss the importance of threshold. How does this relate to the concept of APs being all or none?arrow_forwardWhat would occur if voltage - regulated Na+ and k+ gates opened at the same time rather than at different times, during the production of an action potential?arrow_forward
- Which of the following combinations of spatial summation of postsynaptic potentials (PSP) would result in an action potential in a typical neuron? The voltage given for each PSP is measured as it reaches the axon hillock. Axon A EPSP 25 mV & axon B IPSP 10 mV Axon A IPSP 25 mV & axon B EPSP 10 mV Axon A IPSP 5 mV & axon B IPSP 5 mV Axon A EPSP 5 mV & axon B EPSP 5 mVarrow_forwardThe compound tetraethylammonium (TEA) blocks the voltage-gated changes in potassium permeability that occurs during an action potential. After administration of TEA, what changes would you expect in the action potential?arrow_forwardHelp me pleasearrow_forward
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