The compound tetraethylammonium (TEA) blocks the voltage-gated changes in potassium permeability that occurs during an action potential. After administration of TEA, what changes would you expect in the action potential?
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The compound tetraethylammonium (TEA) blocks the voltage-gated changes in potassium permeability that occurs during an action potential. After administration of TEA, what changes would you expect in the action potential?
Action potentials are known to be the source of neuronal transmission, in the form of electrical signals. The cell membrane has a resting membrane potential of -70 mV with negative towards the inner face of the membrane. The mechanism of generation of an action potential is regulated by ionic channels via their selective permeability of ions and is also determined by the concentration gradient of ions present at a specific point of time (ions present outside and inside of the cell). Small molecules like Tetraethylammonium (TEA) has been used to study the properties of the ion channels. TEA is a potassium-selective ion channel blocker.
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- a) Explain in detail what is occurring at stage A in the graph. (Be specific in terms of what's happening to the ion channels in your explanation if necessary!) b) What does this graph represent as a whole? Explain the main idea it portrays. +40| -70- A 1 2 4 Time/ms Potential Difference/mV BAfter discussing his case with his physician, he learned that he had probably been the victim of pufferfish poisoning. The active toxin in the tissues of this fish is a chemical called tetrodotoxin (TTX). Tetrodotoxin is in a class of chemicals known as neurotoxins because it exerts its effects on neurons. The specific action of tetrodotoxin is that it blocks voltage-gated sodium ion channels. Define the following phrases and terms associated with the signs and symptoms of Dr. Westwood’s TTX poisoning: diaphoresis motor dysfunction paresthesias cyanotic hypoventilating bradycardia gastric lavage oxygen saturation As mentioned in the case description, tetrodotoxin is a molecule that blocks voltage-gated sodium ion channels. What is a voltage-gated sodium ion channel and what is its function? When nerve cells are at rest, there is an unequal amount of positive and negative charges on either side of a nerve cell membrane. This charge difference creates an electrical potential.…Name the three phases of an action potential. Describe for each the underlying molecular basis and the ion involved. Why is the term voltage-gated channel applied to Na+ channels involved in the generation of an action potential?
- The voltage produced by a single nerve or muscle cell is quite small, but there are many species of fish that use multiple action potentials in series to produce significant voltages. The electric organs in these fish are composed of specialized disk-shaped cells called electrocytes. The cell at rest has the usual potential difference between the inside and the outside, but the net potential difference across the cell is zero. An electrocyte is connected to nerve fibers that initially trigger a depolarization in one side of the cell but not the other. For the very short time of this depolarization, there is a net potential difference across the cell, as shown. Stacks of these cells connected in series can produce a large total voltage. Each stack can produce a small current; for more total current, more stacks are needed, connected in parallel. In an electric eel, each electrocyte can develop a voltage of 150 mV for a short time. For a total voltage of 450 V, how many electrocytes must…Based on the graph, the threshold voltage appears to be approximately. (Base your answer to this question on the graph below depicting an action potential.) +60 mV. +30 mV. 0 mV. −30 mV. −60 mV.Compound X has been shown to block voltage-gated K+ channels with an IC50 of 0.1 mM. Which of the following is the most likely to occur in neurones following application of 0.03 mM X? Action potentials would be prolonged and the resting potential would be depolarised. Action potentials would be prolonged but the resting potential would remain the same. Neither resting potential nor action potentials would be affected because the concentration of X is less than the IC50 value. The resting membrane potential would depolarise but there would be no effect on action potentials.
- At the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table), (1) calculate the driving force (in mV) that acts on K+ ions and (2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)Describe the action potential in terms of the different functional states of the voltage- gated Na+ membrane channels (Note: there are three states)What is the role of maximal potassium conductance in the generation and propagation of action potential?
- Give a detailed, step-by-step description of the stages of an action potential, including a description of and explanation for the refractory periods and the rising and falling phases as well as return to rest. In your explanation, make sure to include 1) summation principles, 2) key membrane potentials (values), 3) location of voltage changes along the membrane, 4) states of the various voltage-gated channels. The more detail, the better. There are 5 main steps.What kinds of changes in ion conductance may be expected in an action potential? And how do ion channels permit these changes?In excitable cells, such as neurons, K+ is held at a much higher concentration inside the cell than outside. Which of the following would hold K+ at this concentration?