Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 48, Problem 48.3CR
Summary Introduction

To review: The maximum frequency per unit time at which a neuron could fire action potentials (provided that the action potential and refractory period are of the same length).

Introduction:

Action potentials occur when the depolarization shifts the membrane potential sufficiently. Action potentials are magnitude-dependant and they regenerate in the adjacent regions of the membrane.

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For a nerve fibre axoplasmic and extracellular ion concentrations were found to be respectively: Na+, 15 and 115 mM; K+, 90 and 3 mM; Cl-, 10 and 120 mM. Resting potential was -78 mV. Halving the external [Na+] caused a very slight hyperpolarization; doubling external [K+] caused considerable depolarization; halving the external [Cl-] had no effect. In each case the ions were replaced by impermeable salts. What can you deduce (with reasons) about the resting membrane conductances?
f the absolute refractory period of a neuron is 0.7 milliseconds, what is the maximum frequency of action potentials for this neuron?
If the duration of the absolute refractory period of a neuron is 1 millisecond(ms), how many action potentials are generated by a maximal stimulusin 1 second?

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