Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 12, Problem 27RQ
Which of the following voltages would most likely be measured during the relative refractory period?
- +30 mV
- 0 mV
- -45 mV
- -80 mv
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Draw the current that you would expect to flow during a voltage clamp experiment on a typical neuron. Voltages and time course are shown. Briefly explain why the currents are inward or outward. Be sure to provide scale bars. You should definitely label the Y axis so that the peak current value is obvious.
Draw the Na+ current you would expect if there were physiological ionic gradients.
Draw the K+ current you would expect if there are physiological ionic gradients.
Draw the K+ current you would expect if the bath solution and the intracellular solution are both 125 mM.
Based on the graph, the threshold voltage appears to be approximately. (Base your answer to this question on the graph below depicting an action potential.)
+60 mV.
+30 mV.
0 mV.
−30 mV.
−60 mV.
What is the equilibrium potential of chloride for a typical
neuron?
We will use the following ion concentrations and equilibrium potentials:
lon Inside concentration (mM) Outside concentration (mM) Equilibrium Potential
Sodium 15
145
+60 mV
Potassium 125
5
-85 mV
Chloride 13
150
-65 mV
60mV
-80mV
-90mV
-65mV
Chapter 12 Solutions
Anatomy & Physiology
Ch. 12 - In 2003, the Nobel Prize in Physiology or Medicine...Ch. 12 - Visit this site...Ch. 12 - Visit this site...Ch. 12 - View the University of Michigan Webscope...Ch. 12 - What happens across the membrane of an...Ch. 12 - Visit this site...Ch. 12 - Watch this video...Ch. 12 - Watch this video...Ch. 12 - Which of the following cavities contains a...Ch. 12 - Which structure predominates in the white matter...
Ch. 12 - Which part of a neuron transmits an electrical...Ch. 12 - Which term describes a bundle of axons in the...Ch. 12 - Which functional division of the nervous system...Ch. 12 - What type of glial cell provides myelin for the...Ch. 12 - Which part of a neuron contains the nucleus?...Ch. 12 - Which of the following substances is least able to...Ch. 12 - What type of glial cell is the resident macrophage...Ch. 12 - What two types of macromolecules are the main...Ch. 12 - If a thermoreceptor is sensitive to temperature...Ch. 12 - Which of these locations is where the greatest...Ch. 12 - How long does all the signaling through the...Ch. 12 - What is the target of an upper motor neuron?...Ch. 12 - What ion enters a neuron causing depolarization of...Ch. 12 - Voltage-gated Na+ channels open upon leaching what...Ch. 12 - What does a ligand-gated channel require in order...Ch. 12 - What does a mechanically gated channel respond to?...Ch. 12 - Which of the following voltages would most likely...Ch. 12 - Which of the following is probably going to...Ch. 12 - How much of a change in the membrane potential is...Ch. 12 - A channel opens on a postsynaptic membrane that...Ch. 12 - What neurotransmitter is released at the...Ch. 12 - What type of receptor requires an effector protein...Ch. 12 - Which of the following neurotransmitters is...Ch. 12 - What responses are generated by the nervous system...Ch. 12 - When eating food, what anatomical and functional...Ch. 12 - Multiple sclerosis is a demyelinating disease...Ch. 12 - Which type of neuron, based on its shape, is best...Ch. 12 - Sensory fibers, or pathways, are referred to as...Ch. 12 - If a person has a motor disorder and cannot move...Ch. 12 - What does it mean for an action potential to be an...Ch. 12 - The conscious perception of pain is often delayed...Ch. 12 - If a postsynaptic cell has synapses from five...Ch. 12 - Why is the receptor the important element...
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)arrow_forwardDr. Brainy creates a nerve cell that is only permeable to Caesium ions (Cs+1) at rest. She measures that the concentration of Caesium is 400mM outside the cell and only 50 mM inside the cell. She calculates the Equilibrium potential for Cs+¹ (Ecs) to be +35 mV. If Dr. Brainy uses an electrode to briefly hyperpolarize the cell and then removes the stimulus. She notices that the membrane potential drifts back towards: 0 mV +58 mV +15 mV + 35 mVarrow_forwardShow a complete circuit diagram of the model of the neuron using the specific numerical values for each component: potassium ion concentration outside: 4.0 mmol/L potassium ion concentration inside: 77.5 mmol/Larrow_forward
- You are recording from a cell with a resting membrane potential of -65 mV. You inject 100 pA of current, resulting 58.7 mV. What is the value of tau? With this in mind, what is the capacitance of the cell? Please provide relevant equations to illustrate your thought process. When you terminate the current injection, how long do you expect for it to take for the cell to repolarize to -63 mV?arrow_forwardDr. Brainy creates a nerve cell that is only permeable to Caesium ions (Cs+1) at rest. She measures that the concentration of Caesium is 400mM outside the cell and only 50 mM inside the cell. She calculates the Equilibrium potential for Cs+1 (Ecs) to be +35 mV. If the cell is only permeable to Cs, the resting membrane potential will be: +58 mV 0 mV +35 mV -58 mVarrow_forwardMembrane Potential (mV) +35 0 -50 -70 0 A B C | 2 Time (milliseconds) 3 E 4 Use the figure showing phases of the action potential to answer the following question. Most of the voltage-gated sodium channels become open at label ____, and become inactivated at labelarrow_forward
- For a nerve fibre axoplasmic and extracellular ion concentrations were found to be respectively: Na+, 15 and 115 mM; K+, 90 and 3 mM; Cl-, 10 and 120 mM. Resting potential was -78 mV. Halving the external [Na+] caused a very slight hyperpolarization; doubling external [K+] caused considerable depolarization; halving the external [Cl-] had no effect. In each case the ions were replaced by impermeable salts. What can you deduce (with reasons) about the resting membrane conductances?arrow_forwardA researcher conducts a voltage clamp experiment on a giant squid axon. She clamps a typical neuron at +52mV. In the graph on the right, draw out the current that she will most likely record at this voltage.arrow_forwardWhat would occur if voltage - regulated Na+ and k+ gates opened at the same time rather than at different times, during the production of an action potential?arrow_forward
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