Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Textbook Question
Chapter 4, Problem 5RA
In an inborn error of
a. a genetic change results in the production of a defective enzyme.
b. intermediates produced prior to the defective step accumulate.
c. alternate pathways are taken by intermediates at branch points that precede the defective step.
d. All of these are true.
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Which of the following statements concerning the location of the metabolic pathways is correct?
a.
All reactions of the glycolysis take place in the mitochondria.
b.
All reactions of the TCA cycle take place in the mitochondria.
c.
Some reactions of the TCA cycle take place in the cytosol, and some in mitochondria.
d.
Some reactions of the glycolysis take place in the cytosol, and some in mitochondria.
Which of the following statements about the "central role" of TCA is/are correct?
a. Some metabolic intermediates of TCA are used as non-carbohydrate sources for gluconeogenesis.
b. β-oxidation of lipids produces acetyl-CoA that can enter TCA.
c. All metabolic intermediates in TCA are used in the biosynthesis of amino acids.
d. Degraded amino acids are converted to metabolic intermediates of TCA, then to ketone bodies.
Which of these statements about lactate dehydrogenase is true? a.It is a protein. b.It oxidizes lactic acid. c.It reduces another molecule (pyruvic acid). d.All of these are true.
Chapter 4 Solutions
Human Physiology
Ch. 4 - Use the lock-and-key model to explain how enzymes...Ch. 4 - Explain how enzymes are named, and the nature of...Ch. 4 - Draw graphs to represent the effects of changes in...Ch. 4 - Prob. 4CPCh. 4 - Prob. 5aCPCh. 4 - Prob. 5bCPCh. 4 - Prob. 5cCPCh. 4 - Prob. 6aCPCh. 4 - Define the terms exergonic reaction and endergonic...Ch. 4 - Prob. 7aCP
Ch. 4 - Prob. 7bCPCh. 4 - Which of these statements about enzymes is...Ch. 4 - Which of these statements about enzyme-catalyzed...Ch. 4 - Which of these statements about lactate...Ch. 4 - In a metabolic pathway, a. the product of one...Ch. 4 - In an inborn error of metabolism,
a. a genetic...Ch. 4 - Which of these represents an endergonic...Ch. 4 - Which of these statements about ATP is true? a....Ch. 4 - When oxygen is combined with 2 hydrogens to make...Ch. 4 - Enzymes increase the rate of chemical reactions...Ch. 4 - According to the law of mass action, which of...Ch. 4 - Explain the relationship between an enzyme's...Ch. 4 - Explain how the rate of enzymatic reactions may be...Ch. 4 - Explain how end-product inhibition represents a...Ch. 4 - Prob. 14RACh. 4 - The coenzymes NAD and FAD can "shuttle" hydrogens...Ch. 4 - Prob. 16RACh. 4 - Why do we need to eat food containing niacin and...Ch. 4 - Metabolic pathways can be likened to intersecting...Ch. 4 - Prob. 19RACh. 4 - Suppose you come across a bottle of enzyme tablets...Ch. 4 - Describe the energy transformations that occur...Ch. 4 - Use the reversible reactions involving the...Ch. 4 - Use the graph here and in figure 4.4 to answer the...Ch. 4 - Use the graph here and in figure 4.4 to answer the...Ch. 4 - Prob. 25RACh. 4 - Prob. 26RACh. 4 - Prob. 27RA
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- Which of the following statements concerning gluconeogenesis is NOT true? a. Gluconeogenesis is to make glucose from glycogen. b. Many of the reactions of gluconeogenesis are glycolytic reactions going in reverse. c. The process of gluconeogenesis consumes ATP. d. The process of gluconeogenesis is regulated by ATP. e. Gluconeogenesis maintains the blood glucose level long after all dietary glucose has been absorbed and oxidized.arrow_forwardWhich of these statements about ATP is true?a.The bond joining ADP and the third phosphate is a high-energy bond.b.The formation of ATP is coupled to energy-liberating reactions.c.The conversion of ATP to ADP and Pi provides energy for biosynthesis, cell movement, and other cellular processes that require energy.d.ATP is the “universal energy carrier” of cells.e. .All of these are true.arrow_forwardWhich of the following is true about the phosphorylation of proteins? A. Proteins are usually phosphorylated at amino acids that have hydroxyl group-containing side chains. B. Phosphorylation of proteins is catalyzed by phosphatases. C. Phosphoryation always activates enzymes. D. The specificity in phosphorylation is conferred solely by the amino acid to be phosphorylated.arrow_forward
- Which of the following statements is/are FALSE about glycolysis? A. It is an anaerobic process. B. Some steps occur in cytosol, others in mitochondria. C. It is the conversion of glucose to lactate or ethanol. D. It is the 1st stage of glucose metabolism.arrow_forwardWhich of the following statements concerning glycogen in different tissues is TRUE? a. Liver glycogen serves as a fuel reserve for ATP synthesis during muscle contraction. b. Brain glycogen serves as a source of blood glucose. c. Red blood cells use glycogen as a source of blood glucose. d. Muscle glycogen serves as a fuel reserve for ATP synthesis during muscle contraction. e. Muscle glycogen serves as a source of blood glucose.arrow_forwardWhich of the following is a primary function of the active site of an enzyme? a. It binds allosteric regulators of the enzyme. b. It binds noncompetitive inhibitors of the enzyme. c. It catalyzes the reaction associated with the enzyme. d. It is activated by the presence of the end product of the metabolic pathway in which the enzyme is involved. Clear my choice Question 2 Not yet answered Points out of 2.00 Flag question Question text Which of the following statement about the mass spectrometry is true? a. Large amount of protein sample is needed for mass spectrum, and thus it is very expensive. b. It is a powerful method to determine the 3-dimensional structure of proteins. c. It can be sued for protein location in a living cell. d. It can be used to measure the molecular weight of proteins. e. It can be used to determine the stability of a protein structure in solution. Clear my choice…arrow_forward
- The conversion of citrate to isocitrate is catalyzed by an enzyme classified as a(n): a. Hydrolase b. Oxidoreductase OC. Isomerase Od. Transferasearrow_forwardWhich of the following is true of metabolism? A. Degradative reactions require an input of energy. B. Synthetic pathways are anabolic. C. Catabolism and anabolism are linked by O2. D. Catabolic reactions require the breakdown of ATP, and anabolic reactions generate ATP.arrow_forwardThe important amino acid residues in the active site of enzyme X were found to be aspartic acid and lysine. In an experiment, the pH of the buffer solution in which enzyme X was dissolved was changed from pH 7 to pH 5. What would be the expected effect of this change on the enzyme’s catalytic activity? A. decrease B. increase C. unchanged D. cannot be determinedarrow_forward
- Which of the following statements regarding formation of glucose - 1 - phosphate from glycogen is NOT CORRECT? A. It triggered by low blood glucose B. It requires ATP hydrolysis C. It is catalyzed by glycogen phosphorylase enzyme D. It involves the cleavage of an alpha (1- 4) bondarrow_forwardPenicillin functions by inhibiting an enzyme, transpeptidase, that catalyzes the last step in the bacteria's metabolism which synthesises bacterial the cell-wall. Why does inhibition of this enzyme make Penicilin such an effective medicine in humans, with so few side effects? A. Inhibiting enzymes like this always slows the metabolism of an organism. B. The enzyme is not inhibited in humans because we have resistance to the penicillin. C. The enzyme is part of an essential pathway in the bacteria, which does not exist in humans. D. Inhibiting the enzymes stops respiration in the bacteria, killing quickly.arrow_forwardWhich of the following statements about the Michaelis Menten constant (Km) is correct......A. can be determined by plotting the data v/[S] against 1/[S] B. A large Km indicates a low affinity between the enzyme and the substrate C. A large Km means that a large concentration of substrate is needed for the enzyme to work D. is a measure of the affinity of enzymes for proteins, minerals and vitamins E. Small Km means that a large concentration of substrate is needed for the enzyme to workarrow_forward
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