Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 15, Problem 13RQ
Summary Introduction
To review:
The outlines of interconversions of 2-oxoglutarate, glutamate, and glutamine that provide nitrogen in amino acid biosynthesis.
Introduction:
An amino acid biosynthesis is a group of biological processes through which amino acids are produced. Not all amino acids can be synthesized inside the body, some will be produced by the food or given growth media. Out of 20 different amino acids, human beings are able to produce only 11 amino acids. Â
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Amino transferases catalyze the transfer of amino groups to alpha-keto acids with pyridoxal phosphate as the prosthetic group. Pyridoxal phosphate can accept an amino group, and its aminated form, pyridoxamine phosphate, can donate its amino group to an alpha-keto acid. Draw the detailed mechanism of the transamination reaction in the active site of an aminotransferase. Use the glutamate oxaloacetate transaminase as an example.
Amino transferases catalyze the transfer of amino groups to alpha-keto acids with pyridoxal phosphate as the prosthetic group. Pyridoxal phosphate can accept an amino group, and its aminated form, pyridoxamine phosphate, can donate its amino group to an alpha-keto acid. Illustrate the detailed mechanism of the transamination reaction in the active site of an aminotransferase. Use the glutamate oxaloacetate transaminase as an example.
What cofactors are involved in one-carbon transfer reactions of amino acid anabolism?
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Microbiology: An Evolving Science (Fourth Edition)
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