Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 11, Problem 28CONQ
Telomeres contain a 3′ overhang region, as shown in Figure 11.22. Does telomerase require a 3′ overhang to replicate the telomere region? Explain
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What is a telomere problem and how is telomerase useful in this context?
A). Briefly describe the function of telomerase. B). How does the structure of telomerase allow it to complete the function you described?
(i)
Indicate by drawing where the RNA of Telomerase binds to the telomeric region.
W, X, Y, and Z are the ends of the DNA and RNA strands respectively. Identify ends
of DNA’s X, Y, and Z shown in Figure 1(a) & (b).
(ii)
(a)
Telomerase
-AAUCCCAAU-
TTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG-W’
AАТСССААТСССААТСССАА-Х"
(b)
Telomeric DNA
Figure 1
Chapter 11 Solutions
Genetics: Analysis and Principles
Ch. 11.1 - 1. The complementarity of DNA strands is based on...Ch. 11.1 - 2. To make a new DNA strand, which of the...Ch. 11.1 - 3. The model that correctly describes the process...Ch. 11.2 - 1. A site in a chromosome where DNA replication...Ch. 11.2 - The origin of replication in E. coli contains a....Ch. 11.3 - 1. The enzyme known as ______ uses ________ and...Ch. 11.3 - In the lagging strand, DNA is made in the...Ch. 11.4 - 1. DNA polymerase III is a processive enzyme,...Ch. 11.4 - 2. The proofreading function of DNA polymerase...Ch. 11.5 - 1. In eukaryotes, DNA replication is initiated at...
Ch. 11.5 - 2. Which of the following statements regarding DNA...Ch. 11.5 - 3. In eukaryotes, RNA primers are primarily...Ch. 11.5 - 4. To synthesize DNA, what does telomerase use as...Ch. 11 - What key structural features of the DNA molecule...Ch. 11 - 2. With regard to DNA replication, define the term...Ch. 11 - Which of the following statements is not true?...Ch. 11 - The compound known as nitrous acid is a reactive...Ch. 11 - One way that bacterial cells regulate DNA...Ch. 11 - 6. The chromosome of E. coli contains 4.6 million...Ch. 11 - Here are two strands of DNA. DNA polymerase The...Ch. 11 - A DNA strand has the following sequence:...Ch. 11 - 9. List and briefly describe the three types of...Ch. 11 - 10. As shown in Figure 11.5, five DnaA boxes are...Ch. 11 - 11. Obtain two strings of different colors (e.g.,...Ch. 11 - Sometimes DNA polymerase makes a mistake, and the...Ch. 11 - 13. A short genetic sequence, which may be...Ch. 11 - Single-strand binding proteins keep the two...Ch. 11 - 15. In the following drawing, the top strand is...Ch. 11 - Describe the three important functions of DnaA...Ch. 11 - 17. Draw a picture that illustrates how DNA...Ch. 11 - What is an Okazaki fragment? In which strand of...Ch. 11 - Discuss the similarities and differences in the...Ch. 11 - 20. Explain the proofreading function of DNA...Ch. 11 - 21. What is a processive enzyme? Explain why...Ch. 11 - 22. What enzymatic features of DNA polymerase...Ch. 11 - 23. As shown in Figure 11.24, telomerase attaches...Ch. 11 - If a eukaryotic chromosome has 25 origins of...Ch. 11 - Prob. 25CONQCh. 11 - A diagram of a linear chromosome is shown here....Ch. 11 - As discussed in Chapter 18, some viruses contain...Ch. 11 - 28. Telomeres contain a 3′ overhang region, as...Ch. 11 - 1. Answer the following questions pertaining to...Ch. 11 - An absentminded researcher follows the steps of...Ch. 11 - Figure 11.4b shows an autoradiograph of a...Ch. 11 - 4. As described in Table 11.3, what is the...Ch. 11 - The technique of dideoxy sequencing of DNA is...Ch. 11 - 6. Another technique described in Chapter 21 is...Ch. 11 - The complementarity of its two strands is the...Ch. 11 - Compare and contrast DNA replication in bacteria...Ch. 11 - 3. DNA replication is fast, virtually error-free,...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- describe the telomere shortening problem and how it is solved by telomerase?arrow_forwardIf telomeres are normally shortened after each round of replication in somatic cells (see Chapter 12), what prediction would you make about the length of telomeres in Dolly, the first cloned sheeparrow_forwardHow is telomerase related to aging? How can telomerase-related aging beaddressed therapeutically? What is a potential danger of telomerase activation?arrow_forward
- In yeast cells, telomerase remains active and maintains telomeres of about 300 base pairs. Propose what would happen to the telomeres over time in a yeast lineage in which the following mutations were created. a) The gene encoding the catalytic subunit of the telomerase is deleted. b) What happens to the yeast telomeres over time if the telomerase RNA retains the same anchor but is altered in its templating region?arrow_forwardIn yeast cells, telomerase remains active and maintains telomeres of about 300 base pairs. Propose what would happen to the telomeres over time in a yeast lineage in which the following mutations were created. a) The gene encoding the catalytic subunit of the telomerase is deleted. b) The template portion of the telomerase RNA is changed from 5’-ACACCCACA to 5’-ACAUCUACA.arrow_forwardWhat is a complex of proteins that folds up the telomeres into a structure that shields single-stranded TTAGGG sequences from nucleases and NHEJ enzymes?arrow_forward
- n yeast cells, telomerase remains active and maintains telomeres of about 300 base pairs. Propose what would happen to the telomeres over time in a yeast lineage in which the following mutations were created. The template portion of the telomerase RNA is changed from 5’-ACACCCACA to 5’-ACAUCUACA.arrow_forwardTelomerase activity has been found to be 10 to 20 times more active in cancer cells than in normal somatic cells. What is the significance of this circumstance?arrow_forwardSome viruses, such as SV40, contain closed circular DNAS carrying nucle- osomes. If the SV40 viral chromosome is treated with topoisomerase, and the histone is then removed, it is still supercoiled. If histones are removed before topoisomerase treatment, however, the DNA is relaxed. Explain.arrow_forward
- In the catalytic center of DNA polymerases, the presence of Mg2+ ions and aspartate residues close to these ions is required. What is the role of these aspartate residues that are found close to the magnesium ions? What is the role of the magnesium ions in the polymerization of nucleotides?arrow_forwardExplain why telomeres and telomerase are needed for replication of eukaryotic chromosomes but not bacterial chromosomes.arrow_forwardMany of the gene products involved in DNA synthesis were initially defined by studying mutant E. coli strains that could not synthesize DNA. (a) The dnaE gene encodes the a subunit of DNA polymerase III. What effect is expected from a mutation in this gene? How could the mutant strain be maintained? (b) The dnaQ gene encodes the e subunit of DNA polymerase. What effect is expected from a mutation in this gene?arrow_forward
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