Concept explainers
To review:
Three essential posttranslational steps are mentioned in figure
a. A research scientist is intent to produce human insulin in the bacterial species E. coli. Whether the genetic code permits the production of human proteins from bacterial cells? Explain with reason.
b. Describe why it is not feasible to insert the complete human insulin gene E. coli and anticipate the production of insulin.
c. Recombinant human insulin that is prepared by inserting human DNA encoding insulin into E. coli, is one the most extensively used recombinant in pharmaceutical products in the world. Recognize the part of the human insulin gene used to generate recombinant bacteria that produce human insulin.
Introduction:
Preproinsulin is the primary translational product of the Insulin gene. It is made up of
The post translational modifications include cleavage of N terminal amino acids, Chemical modification of internal amino acids, and polypeptide cleavage.
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Genetic Analysis: An Integrated Approach (3rd Edition)
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- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning