Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 9, Problem 38P
Summary Introduction

To review:

The mRNA codon AUG is used as the start codon by organisms of all three domains of life.

a. The organisms of all three domains use the same amino acid as the initial amino acid in translation is to be checked and explained. Similarities and differences are to be identified.

b. Even though AUG being the most common start codon sequence, very less proteins have methionine as the first amino acid. Explain with reason.

Introduction:

Start codon of mRNA refers to the first codon of mRNA transcript that initiates the translation process. The start codon is AUG. It codes for methionine. Methionine is one of the amino acid that is encoded by a single codon in the genetic code. Not all proteins start with methionine, the second start codon is the modified form of methionine known as fMet. In prokaryotes, the initiation codon is fMet- formyl methionine. During the process of translation, tRNA molecule specifically recognizes the start codon with the help of initiation factors.

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Students have asked these similar questions
The nucleotide triplet AAA is the codon for Lysine. This codon originated from the following piece of DNA: 3’ – TTT – 5’.  A) Illustrate the wobble hypothesis, listing an alternative codon for Lysine. List the newly created mRNA codon AND the mutated DNA sequence that was used as a template. B)Illustrate how this codon (AAA) could easily mutate into a STOP codon via a single nucleotide substitution. List the newly created STOP codon AND the mutated DNA sequence that was used for a template in this case.
Transcribe the DNA strand given above to write the sequence of the mRNA strand in the 5’ to 3’ direction.                                                                                                                    Use the table and write the sequence of the resulting peptide.                                      Is it possible for a codon to code for another amino acid?  What will be the effect if a mutation changes the codon UAU to UAA?  What is a reading frame?                                                  If you are given a nucleotide sequence, how would you find Open Reading Frames? DISCUSS the reason why there are leading and lagging strands in replication?
Consider the following original coding sequence of a gene that codes for a short 5- amino acid polypeptide: 5'-ATGGGCTCGAACTCATAA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U U A UUU UUC- UUA UUG- CUU CUC CUA CUG- U Phe (F) Leu (L) Leu (L) Second base in codon Val (V) UCU - UCC UCA UCG CCU CCC CCA CCG AUU ACU- AUC Ile (1) ACC AUA- ACA AUG Met (M) start ACG GUU GCU- GUC GCC GUA GCA GUG GCG- C Ser (S) Pro (P) Thr (T) Ala (A) UAU UAC UAAT UAG CAU CAC CAA CAG AAU AAC AAA AAG GAU GAC GAA GAG A Tyr (Y) STOP His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) G UGU UGC UGA STOP UGG Trp (W) Cys (C) CGU CGC CGA CGG AGU AGC AGA 1 AGG GGU- GGC GGA GGG Arg (R) Ser (S) Arg (R) Gly (G) U C A G U C A G U C A G U C A G Last base in codon

Chapter 9 Solutions

Genetic Analysis: An Integrated Approach (3rd Edition)

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