Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 7, Problem 19QP
Equalizing the Expression of X Chromosome Genes in Males and Females
Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?
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X chromosome inactivation in a diploid XX female is not completely inactivated, explain?
Explain why a person with Klinefelter Syndrome (XXY) still exhibits abnormal phenotypes despite the fact that one of the extra X Chromosome is inactivated practically leaving an XY active sex chromosomes similar to a normal male?
Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female.
Draw a dihybrid Punnet square to show the possible offspring:
Chapter 7 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 7.6 - Prob. 1EGCh. 7.6 - Prob. 2EGCh. 7 - As outlined in this chapter, sex can be defined at...Ch. 7 - As outlined in this chapter, sex can be defined at...Ch. 7 - Prob. 1QPCh. 7 - The Human Reproductive System Discuss and compare...Ch. 7 - Prob. 3QPCh. 7 - A Survey of Human Development from Fertilization...Ch. 7 - Prob. 5QPCh. 7 - Prob. 6QP
Ch. 7 - Prob. 7QPCh. 7 - How Is Sex Determined? The absence of a Y...Ch. 7 - Prob. 9QPCh. 7 - Mutations Can Uncouple Chromosomal Sex from...Ch. 7 - Prob. 11QPCh. 7 - Mutations Can Uncouple chromosomal Sex from...Ch. 7 - Prob. 13QPCh. 7 - Sex-Influenced and Sex-Limited Traits What method...Ch. 7 - Prob. 15QPCh. 7 - Prob. 16QPCh. 7 - Equalizing the Expression of X Chromosome Genes in...Ch. 7 - Equalizing the Expression of X Chromosome Genes in...Ch. 7 - Equalizing the Expression of X Chromosome Genes in...
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- Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. State the genotype of the male and the female.arrow_forwardAnalysis of X-Linked Dominant and Recessive Traits In the eighteenth century, a young boy with a skin condition known as ichthyosis hystrix gravior was identified. The phenotype of this disorder includes thickening of skin and the formation of loose spines that are sloughed off periodically. This man married and had six sons, all of whom had the same condition. He also had several daughters, all of whom were unaffected. In all succeeding generations, the condition was passed on from father to son. What can you theorize about the location of the gene that causes ichthyosis hystrix gravior?arrow_forwardEqualizing the Expression of X Chromosome Genes in Males and Females How many Barr bodies would the following individuals have? a. normal male b. normal female c. Klinefelter male d. Turner femalearrow_forward
- Almost all calico cats (one is pictured in FIGURE 10.7B) are female. Why? B When this calico cat was an embryo, one of the two X chromosomes was inactivated in each of her cells. The descendants of the cells formed her adult body, which is a mosaic for expression of X chromosome genes. Black fur arises in patches where genes on the X chromosome inherited from one parent are expressed; orange fur arises in patches where genes on the X chromosome inherited from the other parent are expressed. FIGURE 10.7 Animated X chromosome inactivation.arrow_forwardFollowing X-chromosome inactivation, most of the genes on theinactivated X chromosome are silenced. Explain how. Name onegene that is not silenced.arrow_forwardBarr bodies are formed to adjust X chromosome dosage in species other than humans, such as Drosophila (fruit flies) and C. elegans (nematodes). True or False ?arrow_forward
- Including the sex chromosomes, the chromosome number of a normal human cell is and the chromosome number of this Hela cell is - (Hint: Chromosome number is different from total chromosome count.) It appears that this Hela cell has extra copies of chromosome 16. Henrietta Lacks was female, so, naturally, all the cells from her derived cancerous cell line have chromosomes. This HeLa cell, interestingly, has copies of its sex chromosomes. What sex is the normal human karyotype displayed here? O Male O Femalearrow_forwardXX individuals can be sex-reversed males if one of their X chromosomes contains a translocated portion of the Y chromosome that includes the SRY gene. In light of what you now know about X-chromosome inactivation, it seems that this karyotype might have more complex consequences. In fact, although most such males are completely sex-reversed, X-chromosome inactivation can cause some of these XX males to have varying degrees of residual female characteristics. a. X-chromosome inactivation in normal XX embryos occurs earlier in development than SRY production in normal XY embryos. When present on a translocation X chromosome, SRY is subject to inactivation. Formulate a hypothesis to explain why many XX individuals with a translocation X chromosome that includes the SRY gene are not completely sex-reversed (male). b. Based on your answer to part (a), why do you think some individuals with this karyotype are completely sex-reversed?arrow_forwardConsidering the following chromosome which is represented as a series of genes on each arm separated by the centromere. Describe the type of mutation required to produce each of the mutant chromosomes below. ABCDEFG*HIJKLMNarrow_forward
- Although most tortoiseshell cats are female, a litter of kittens will occasionally contain a male tortoiseshell. Which of the following can explain tortoiseshell coat color in a male kitten? Please explain in detail. The male kitten has an extra Y chromosome The male kitten has an extra X chromosome The male kitten has no X chromosome The male kitten cannot carry out X-inactivationarrow_forwardDiploid somatic cells of elephants have 56 chromosomes. If nondisjunction of one of a male elephant’s chromosomes occurs in meiosis II, at the end of meiosis the four resulting sperm are expected to have the chromosome complement:arrow_forwardWhy is aneuploidy of the sex chromosomes less debilitating than aneuploidy of even the smallest autosomes? (Note: multiple responses are correct, please choose the best answer(s)) Select one or more: Only one X chromosome is required at any given time. Additional X chromosomes (as in females) are inactivated in most cells except for gametes Dosage compensation requires that all excess chromosomes (i.e. 2 or more) are activated at all times during the cell cycle The Y chromosome carries a number of critical genes involved in spermatogenesis and sex development. Therefore, having two copies of the Y chromosome results in the overproduction of sperm and increased fertility The Y chromosome carries a number of critical genes required for spermatogenesis and sex development, but very few other genes. Therefore, having two copies of the Y chromosome has minimal impact on the balance of gene expressionarrow_forward
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