XX individuals can be sex-reversed males if one of their X chromosomes contains a translocated portion of the Y chromosome that includes the SRY gene. In light of what you now know about X-chromosome inactivation, it seems that this karyotype might have more complex consequences. In fact, although most such males are completely sex-reversed, X-chromosome inactivation can cause some of these XX males to have varying degrees of residual female characteristics. a. X-chromosome inactivation in normal XX embryos occurs earlier in development than SRY production in normal XY embryos. When present on a translocation X chromosome, SRY is subject to inactivation. Formulate a hypothesis to explain why many XX individuals with a translocation X chromosome that includes the SRY gene are not completely sex-reversed (male). b. Based on your answer to part (a), why do you think some individuals with this karyotype are completely sex-reversed?

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XX individuals can be sex-reversed males if one of their X chromosomes contains a translocated
portion of the Y chromosome that includes the SRY gene. In light of what you now know about
X-chromosome inactivation, it seems that this karyotype might have more complex
consequences. In fact, although most such males are completely sex-reversed, X-chromosome
inactivation can cause some of these XX males to have varying degrees of residual female
characteristics.
a. X-chromosome inactivation in normal XX embryos occurs earlier in development than
SRY production in normal XY embryos. When present on a translocation X
chromosome, SRY is subject to inactivation. Formulate a hypothesis to explain why
many XX individuals with a translocation X chromosome that includes the SRY gene are
not completely sex-reversed (male).
b. Based on your answer to part (a), why do you think some individuals with this karyotype
are completely sex-reversed?
Transcribed Image Text:XX individuals can be sex-reversed males if one of their X chromosomes contains a translocated portion of the Y chromosome that includes the SRY gene. In light of what you now know about X-chromosome inactivation, it seems that this karyotype might have more complex consequences. In fact, although most such males are completely sex-reversed, X-chromosome inactivation can cause some of these XX males to have varying degrees of residual female characteristics. a. X-chromosome inactivation in normal XX embryos occurs earlier in development than SRY production in normal XY embryos. When present on a translocation X chromosome, SRY is subject to inactivation. Formulate a hypothesis to explain why many XX individuals with a translocation X chromosome that includes the SRY gene are not completely sex-reversed (male). b. Based on your answer to part (a), why do you think some individuals with this karyotype are completely sex-reversed?
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