Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 6, Problem 1CS
A 4-month-old infant had been running a moderate fever for 36 hours, and a nervous mother made a call to her pediatrician. Examination and tests revealed no outward signs of infection or cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother was not placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues.
1. Was the pediatrician correct in stating that bacteria can exchange antibiotic resistance genes? If so, how is this possible?
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A4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues.
Question How should the pediatrician balance his ethical responsibility to provide effective treatment to the present patient with…
A4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues.
Question:If you were an anxious parent of the patient, would it change your mind if you learned that a woman died in 2016 from a…
Results from a Kirby Bauer antibiotic assay on a Gram-negative bacterial culture are described as follows: A) the bacterium is resistant to penicillin, an antibiotic that targets synthesis of the peptidoglycan cell wall and B) the bacterium is resistant to tetracycline, an antibiotic that targets the small subunit of the ribosome, inhibiting protein synthesis. Which of the results represents intrinsic resistant and which represents acquired resistants?
Chapter 6 Solutions
Concepts of Genetics (12th Edition)
Ch. 6 - When the interrupted mating technique was used...Ch. 6 - In a transformation experiment involving a...Ch. 6 - In complementation studies of the rII locus of...Ch. 6 - A 4-month-old infant had been running a moderate...Ch. 6 - Prob. 2CSCh. 6 - Prob. 3CSCh. 6 - Prob. 4CSCh. 6 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 6 - Review the Chapter Concepts list on p. 123. Many...Ch. 6 - With respect to F+ and F bacterial matings, answer...
Ch. 6 - List all major differences between (a) the F+ F...Ch. 6 - Describe the basis for chromosome mapping in the...Ch. 6 - In general, when recombination experiments are...Ch. 6 - Why are the recombinants produced from an Hfr F...Ch. 6 - Describe the origin of F bacteria and merozygotes.Ch. 6 - In a transformation experiment, donor DNA was...Ch. 6 - Describe the role of heteroduplex formation during...Ch. 6 - Explain the observations that led Zinder and...Ch. 6 - Prob. 12PDQCh. 6 - Two theoretical genetic strains of a virus (abc...Ch. 6 - The bacteriophage genome consists of many genes...Ch. 6 - If a single bacteriophage infects one E. coli cell...Ch. 6 - A phage-infected bacterial culture was subjected...Ch. 6 - In recombination studies of the rII locus in phage...Ch. 6 - In an analysis of rII mutants, complementation...Ch. 6 - If further testing of the mutations in Problem 18...Ch. 6 - Using mutants 2 and 3 from Problem 19, following...Ch. 6 - During the analysis of seven rII mutations in...Ch. 6 - In studies of recombination between mutants 1 and...Ch. 6 - Prob. 23ESPCh. 6 - An Hfr strain is used to map three genes in an...Ch. 6 - A plaque assay is performed beginning with 1 mL of...Ch. 6 - In a cotransformation experiment, using various...Ch. 6 - For the experiment in Problem 26, another gene, g,...Ch. 6 - Bacterial conjugation, mediated mainly by...Ch. 6 - A study was conducted in an attempt to determine...
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- 10) If the bacterium Staphylococcus aureus experiences a cost for maintaining one or more antibiotic- resistance genes, what would happen in environments that lack antibiotics? A) These genes would be maintained in case the antibiotics appear. B) These bacteria would be outcompeted and replaced by bacteria that have lost these genes. C) These bacteria would try to make the cost worthwhile by locating and migrating to microenvironments where traces of antibiotics are present. D) The number of genes conveying antibiotic resistance would increase in these bacteria. 11) When nonrandom mating occurs in a population so that individuals prefer to mate with similar individuals, allele frequencies should A) remain the same, but homozygotes will be overrepresented in the population. B) remain the same, but heterozygotes will be overrepresented in the population. C) change and heterozygotes will be overrepresented in the population. D) change and homozygotes will be overrepresented in the…arrow_forwardAn F' merozygote is formed as a result of the following events: 1) the recipient cell receives genes which used to be a part of an Hfr bacterium chromosome 2) an F' bacterium excuses an F factor from another bacterium chromosome 3) an F factor that was imprecisely excised from Hfr chromosome was transferred to an F- bacterium 4)an F' bacterium conjugate with an F- bacterium 5) an F' bacterium incorporates an F factor into its chromosome 6) an F- bacterium incorporates an F factor into its chromosomearrow_forwardYou have isolated a strain of E.coli that is resistant to penicillin,streptomycin,chloramphenicol and tetracycline. You also observe that when you mix this strain with a strain that is sensitive to all four antibiotics, the new strain becomes resistant to streptomycin,penicillin and chloramphenicol but not tetracycline. Explain how this is so?arrow_forward
- 1) What is NDM-1? How can NDM-1 spread to different types of bacteria? 2) Why are Gram negative bacteria so much harder to treat with antibiotics? 3) What is KPC? Where does it live?arrow_forwardUsually, bacteria only make tryptophan when tryptophan is absent or available in low concentration. However, a particular bacterial mutation makes tryptophan all the time whether or not tryptophan is present. What could explain this phenotype? A) the terminator hairpin is unable to form B) the antiterminator hairpin is unable to form C) trpE is mutated D) trpD is mutated E) trpA is mutatedarrow_forwardAll of the following apply to Luria and Delbruck’s 1943 study of mutation rates in E. Coli and T1 phage except: A) it served as an example of an inflexible test B) it involved looking for T1-resistant bacteria as an end measure C) it showed that numbers of mutant organisms observed after T 1 phage were added to the culture tended to vary from experiment to experiment D) it rejected the possibility of adaptive mutations E) it supported the concept of spontaneous mutation ratesarrow_forward
- A patient admitted to the hospital for fever and coughing is diagnosed with an active tuberculosis infection, and is treated with an antibiotic named rifampin. The antibiotics seemed successful, and his subsequent tests for tuberculosis came back negative. However, he was re-admitted to the hospital two months later with similar symptoms, was treated with rifampin again, and died of respiratory failure shortly thereafter. It was concluded that he had been infected with an antibiotic-resistant strain of M. tuberculosis. Does this situation meet the criteria for evolution by natural selection? Briefly explain how each of Darwin’s postulates is met/not met: a. Individuals in a population vary in traits. b. Traits are heritable. c. More offspring are produced than can survive, and only some individuals survive and reproduce. d. Individuals with certain heritable traits are more likely to survive and reproduce than others.arrow_forwardDuring the anthrax crisis of 2001, public health officials urged citizens not to take the antibiotic ciprofloxacin as a preventative measure. Public health officials were concerned that overuse of ciprofloxacin would lead to resistant varieties of anthrax and other bacterial pathogens. Ciprofloxacin is one of the few readily available antibiotics that can treat anthrax. 1)Do you think that public health officials should more directly regulate the availability of ciprofloxacin to ensure its proper use? 2)Why?arrow_forwardPenicillin was first used in the 1940s to treat gonorrhea infections produced by the bacterium Neisseria gonorrhoeae. In 1984, according to the CDC, fewer than 1% of gonorrhea infections were caused by penicillin-resistant N. gonorrhoeae. By 1990, more than 10% of cases were penicillin resistant and a few years later the level of resistance was 95%. Explain the various ways this resistance could be spread among the cells. Could this resistance pass to other infectious bacteria from N. gonorrhoeae?arrow_forward
- What is wrongly matched? A) None of the above B) Transfer of genetic material from 1 cell to --- conjugation. Another involving cell to cell contact C) Transfer of DNA from 1 cell to another by a Bacteriophage---Transduction D) Bacterial cell in which the F factor has become integrated---HFrarrow_forwardWhich of the following is TRUE when one assay bacteriophage titers? You should: a) first mix the phages with a live bacterial culture and then pour the mixture on the agar plate b) directly add the phage dilution onto the surface of an agar plate c) add tryptic soy broth to the phage dilution and incubate overnight d) incubate a phage solution with live bacterial cells for several minutes. You must add soft agar to the mixture before pouring the content on the agar platearrow_forwardArrange the following steps involved in Gene cloning in the correct orderi) Isolation of desired geneii) Insertion of isolated gene to the vectoriii) Introduction of recombinant vector to the hostiv)Expression of recombinant gene in hostv) Extraction of recombinant gene producta) i, ii, iii, iv, vb) v, iv, iii, ii, ic) i, iii, ii, iv, vd) iv, v, ii, i, iiiarrow_forward
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genetic recombination strategies of bacteria CONJUGATION, TRANSDUCTION AND TRANSFORMATION; Author: Scientist Cindy;https://www.youtube.com/watch?v=_Va8FZJEl9A;License: Standard youtube license