Study Guide for Campbell Biology
Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 48, Problem 7IQ
Summary Introduction

To describe: The reasons due to which acetylcholine has opposite effects for skeletal muscle contraction and cardiac muscle contraction.

Introduction: Acetylcholine is a common neurotransmitter in invertebrates as well as vertebrates. It is released by the motor neurons of the nervous system at the neuromuscular junction. A junction between a neural cell and a muscle cell that is stimulated due to the release of acetylcholine is termed as a neuromuscular junction.

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Acetylcholine is a common neurotransmitter released at the synapse. Predict the consequences for muscle activation of decreased acetylcholine esterase activity at nerve-muscle synapses.
When the neurotransmitter acetylcholine (ACh) binds the acetylcholine receptor (a GPCR) on muscle cells, it causes them to contract. ZIGGY, a chemical analog of ACh, also binds to the same acetylcholine receptor on muscle cells, but instead causes the muscle cells to relax. For this reason, it is sometimes prescribed as a muscle relaxer. Explain in 3-4 sentences how ZIGGY could cause muscle relaxation. How can both ZIGGY and ACh bind the same GPCR? And then how can they have different effects on the cells, despite binding to the same receptor on the same cells?
The effects of neurotransmitter binding are very brief. Explain.
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