Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 26, Problem 9EQ
Summary Introduction
To review:
The expected results of the following, the loss of function mutation in each protein or the presence of stripe in each mutation.
A. Kruppel
B. bicoid
C. hunchback
D. giant
Introduction:
The branch of science that concerns with heredity, the study of genes and
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In comparison to experimental results from the genetic manipulation of an invertebrate model, what pathologic outcome(s) would suggest that multiple homologs of a disease gene are present in humans?
a. Missing the essential gene homolog that is lethal in fruit flies is also lethal in human infants.
b. Different homologs of the essential gene are each expressed in different human organs, and mutations in these duplicated genes cause organ-specific diseases.
c. Different homologs of the essential gene are each expressed in different stages of early child development, and mutations in each of these duplicated genes cause different diseases.
d. In humans, defects in different homologs of the essential gene cause different loss-of-function diseases due to subfunctionalization.
e. The essential gene is lethal in fruit flies, but there is no disease phenotype exhibited in people.
) Explain how and why dorsal/ventral polarity will be affected in fly
Question 3 (1.
embryos carrying the following mutations; also in each case darken in the area of the cells
in the cross-sectional view of the fly embryo which are expected to express the paulie gene.
D = dorsal; V = ventral.
a) a mutation which results in the deletion of the cytoplasmic domain of the Cookie protein.
b) A mutation which results in a constitutively active Bombe protein, i.e. the Bombe protein
is always in an activated state.
c) A mutation which causes the Pickle protein to be retained in the cytoplasm of the
embryo.
What is the difference between a maternal-effect gene and a zygotic gene? Of the following genes that play a role in Drosophila development, which are maternal-effect genes and which are zygotic? Explain your answer.
A. nanos
B. Antp
C. bicoid
D. lab
Chapter 26 Solutions
Genetics: Analysis and Principles
Ch. 26.1 - Prob. 1COMQCh. 26.1 - Prob. 2COMQCh. 26.1 - Which of the following is the correct order for...Ch. 26.2 - Prob. 1COMQCh. 26.2 - Prob. 2COMQCh. 26.2 - Prob. 3COMQCh. 26.2 - Prob. 4COMQCh. 26.3 - Prob. 1COMQCh. 26.3 - Prob. 2COMQCh. 26.3 - 3. Myogenic bHLH proteins are ___________ that...
Ch. 26.4 - Prob. 1COMQCh. 26.4 - Prob. 2COMQCh. 26.5 - 1. A key event that initially determines female or...Ch. 26.5 - Prob. 2COMQCh. 26 - 1. What four types of cellular processes must...Ch. 26 - Prob. 2CONQCh. 26 - Prob. 3CONQCh. 26 - 4. Which of the following statement(s) is/are true...Ch. 26 - Discuss the morphological differences between the...Ch. 26 - Prob. 6CONQCh. 26 - Explain what a morphogen is, and describe how it...Ch. 26 - 8. What is positional information? Discuss three...Ch. 26 - Prob. 9CONQCh. 26 - Prob. 10CONQCh. 26 - 11. Describe the function of the Bicoid protein....Ch. 26 - With regard to development, what are the roles of...Ch. 26 - Discuss the role of homeotic genes in development....Ch. 26 - Describe the molecular features of the homeobox...Ch. 26 - What would you predict to be the phenotype of...Ch. 26 - Prob. 16CONQCh. 26 - If a mutation in a homeotic gene produced the...Ch. 26 - 18. Explain how loss-of-function mutations in the...Ch. 26 - What is the difference between a maternal-effect...Ch. 26 - Prob. 20CONQCh. 26 - Prob. 21CONQCh. 26 - Prob. 22CONQCh. 26 - 23. Discuss the similarities and differences...Ch. 26 - 24. What is cell differentiation? Discuss the role...Ch. 26 - Prob. 25CONQCh. 26 - What is a totipotent cell? In each of the...Ch. 26 - 27. What is a meristem? Explain the role of...Ch. 26 - Prob. 28CONQCh. 26 - Predict the phenotypic consequences of each of the...Ch. 26 - 30. Explain how alternative splicing affects sex...Ch. 26 - Prob. 1EQCh. 26 - Compare and contrast the experimental advantages...Ch. 26 - 3. What is meant by the term cell fate? What is a...Ch. 26 - 4. Explain why a cell lineage diagram is necessary...Ch. 26 - Explain the rationale behind the use of the bag of...Ch. 26 - Prob. 6EQCh. 26 - Take a look at question 2 in More Genetic TIPS...Ch. 26 - All of the homeotic genes inDrosophilahave been...Ch. 26 - Prob. 9EQCh. 26 - wo techniques commonly used to study the...Ch. 26 - Prob. 11EQCh. 26 - Prob. 12EQCh. 26 - 13. Another way to study the role of proteins...Ch. 26 - 14. Why have geneticists used reverse genetics to...Ch. 26 - Prob. 1QSDCCh. 26 - Prob. 2QSDCCh. 26 - Prob. 3QSDC
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