Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 22, Problem 9P
Interpretation Introduction
Interpretation:
ATP yield by the complete oxidation of heptadecanoic fatty acid should be determined.
Concept introduction:
The fatty acids are degraded in a sequential manner that is two carbon units at the carboxyl end of the molecule are removed in each step. The process of beta-oxidation of fatty acids takes place inside the mitochondria, and it includes the oxidation of beta carbon of the fatty acids.
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G. ENZYME CLASSIFICATION.
Identify the main class of enzymes used to catalyzed the following reactions:
1. Lactate dehydrogenase:
NADH+H
NAD
HC-OH
CH3
CH
Pynnte
Lactate
2. Methylmalonyl-CoA mutase:
CH CH
SCOA
CH,CH,
SCOA
coenzyme B12
COO
COO
methylmalonyl-CoA
succinyl-CoA
3. Enolase:
0.
H–Ċ–0–P–0-
C-0–P-0- + H,0
HO–CH,
CH 6
Phosphoenolpyruvate
2-Phosphoglycerate
4. Chymotrypsin:
-0–CH,CH3 + H2O
- RCOOH + HOCH,CH3
5. Pyruvate carboxylase:
coo
• co, • ATP + H,0
H-C-H . ADP + P, + 2H
čoo
CH,
Pyruvate
Oxaleacetate
Long explanations are NOT NEEDED. Answer only d and e.
ATP accounting.
Consider 1 molecule of the sucrose (monomeric units: glucose and fructose) that will undergo complete oxidation.
-Number of pyruvate molecules after glycolysis is 4.-Net ATP produced in glycolysis only (via substrate-level phosphorylation) is 2.-Number of NADH produced using the pyruvate dehydrogenase complex reaction is 1.
Now find:d. Number of NADH and FADH2 produced from Krebs cycle.e. Net ATP produced (complete oxidation via Malate aspartate shuttle).
Instructions.
Given each set of information which may include common name(s) and the reaction catalyzed, you are required to identify the main class of the specific enzyme described.
Name: citryl-CoA synthetase
Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
Name: D-xylulose reductase
Reaction: xylitol + NAD+ = D-xylulose + NADH + H+
Name: cellobiose phosphorylase
Reaction: cellobiose phosphate = α-D-glucose 1-phosphate + D-glucose
Name: carbonic anhydrase
Reaction: H2CO3 = CO2 + H2O
Other info: The enzyme catalyzes the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH.
Name: pantoate activating enzyme
Reaction: ATP + (R)-pantoate = AMP + diphosphate + (R)-pantothenate.
Chapter 22 Solutions
Biochemistry
Ch. 22 - Prob. 1PCh. 22 - Prob. 2PCh. 22 - Prob. 3PCh. 22 - Prob. 4PCh. 22 - Prob. 5PCh. 22 - Prob. 6PCh. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Prob. 9PCh. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Prob. 12PCh. 22 - Prob. 13PCh. 22 - Prob. 14PCh. 22 - Prob. 15PCh. 22 - Prob. 16PCh. 22 - Prob. 17PCh. 22 - Prob. 18PCh. 22 - Prob. 19PCh. 22 - Prob. 20PCh. 22 - Prob. 21PCh. 22 - Prob. 22PCh. 22 - Prob. 23PCh. 22 - Prob. 24PCh. 22 - Prob. 25PCh. 22 - Prob. 26PCh. 22 - Prob. 27PCh. 22 - Prob. 28PCh. 22 - Prob. 29PCh. 22 - Prob. 30PCh. 22 - Prob. 31PCh. 22 - Prob. 32PCh. 22 - Prob. 33PCh. 22 - Prob. 34PCh. 22 - Prob. 35PCh. 22 - Prob. 36PCh. 22 - Prob. 37PCh. 22 - Prob. 38PCh. 22 - Prob. 39PCh. 22 - Prob. 40PCh. 22 - Prob. 41PCh. 22 - Prob. 42PCh. 22 - Prob. 43PCh. 22 - Prob. 44PCh. 22 - Prob. 45PCh. 22 - Prob. 46PCh. 22 - Prob. 47PCh. 22 - Prob. 48PCh. 22 - Prob. 49PCh. 22 - Prob. 50PCh. 22 - Prob. 51PCh. 22 - Prob. 52PCh. 22 - Prob. 53PCh. 22 - Prob. 54PCh. 22 - Prob. 55PCh. 22 - Prob. 56PCh. 22 - Prob. 57PCh. 22 - Prob. 58PCh. 22 - Prob. 59PCh. 22 - Prob. 60PCh. 22 - Prob. 61PCh. 22 - Prob. 62P
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