Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 22, Problem 34P
Interpretation Introduction
Interpretation:
The reason for citrate being an inhibitor for phosphofructokinase must be determined.
Concept introduction:
Phosphofructokinase is the most important regulator in the process of glycolysis. It is composed of 4 subunits and is controlled by various inhibitors and activators. It catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. It is inhibited by ATP and citrate.
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Fill in the blanks below (input numbers only!) about the
metabolism of hexanoic acid, a fatty acid that is one of
the components of vanilla, and whose formula is
CH3(CH2)4COOH:
First, the fatty acid is activated by attaching CoA, which
costs
ATP molecules. The fatty acid
is then broken down through a beta-oxidation spiral, to
make
acetyl CoA molecules. This will
require
"turns" of the beta-oxidation
process.
Since each turn of the cycle yields
ATP molecules, and each acetyl COA will yield
ATP molecules by going through the
rest of its metabolism, the net ATP molecules produced
from one molecule of this fatty acid will be
. Glucagon secretion causes inhibition of intracellular acetyl-CoA car-
boxylase activity by several mechanisms. Name all you
can think of.
Acetyl-CoA and succinyl-CoA are both highenergy thioesters, but their chemical energy is put to differentuses. Elaborate.
Chapter 22 Solutions
Biochemistry
Ch. 22 - Prob. 1PCh. 22 - Prob. 2PCh. 22 - Prob. 3PCh. 22 - Prob. 4PCh. 22 - Prob. 5PCh. 22 - Prob. 6PCh. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Prob. 9PCh. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Prob. 12PCh. 22 - Prob. 13PCh. 22 - Prob. 14PCh. 22 - Prob. 15PCh. 22 - Prob. 16PCh. 22 - Prob. 17PCh. 22 - Prob. 18PCh. 22 - Prob. 19PCh. 22 - Prob. 20PCh. 22 - Prob. 21PCh. 22 - Prob. 22PCh. 22 - Prob. 23PCh. 22 - Prob. 24PCh. 22 - Prob. 25PCh. 22 - Prob. 26PCh. 22 - Prob. 27PCh. 22 - Prob. 28PCh. 22 - Prob. 29PCh. 22 - Prob. 30PCh. 22 - Prob. 31PCh. 22 - Prob. 32PCh. 22 - Prob. 33PCh. 22 - Prob. 34PCh. 22 - Prob. 35PCh. 22 - Prob. 36PCh. 22 - Prob. 37PCh. 22 - Prob. 38PCh. 22 - Prob. 39PCh. 22 - Prob. 40PCh. 22 - Prob. 41PCh. 22 - Prob. 42PCh. 22 - Prob. 43PCh. 22 - Prob. 44PCh. 22 - Prob. 45PCh. 22 - Prob. 46PCh. 22 - Prob. 47PCh. 22 - Prob. 48PCh. 22 - Prob. 49PCh. 22 - Prob. 50PCh. 22 - Prob. 51PCh. 22 - Prob. 52PCh. 22 - Prob. 53PCh. 22 - Prob. 54PCh. 22 - Prob. 55PCh. 22 - Prob. 56PCh. 22 - Prob. 57PCh. 22 - Prob. 58PCh. 22 - Prob. 59PCh. 22 - Prob. 60PCh. 22 - Prob. 61PCh. 22 - Prob. 62P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Select the BEST answer. Increasing the concentration of Fructose-2,6 bisphosphate would Inhibit Phosphofructokinase 2 Increase the concentration of Fructose-1,6 bisphosphate (phosphofructose isomerase) O increase the synthesis of glycogen Increase the carboxylation of Ac-CoA to make more malonyl-CoA increase the concentration of Pyruvatearrow_forwardWhat is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductasearrow_forwardWhich of the following is NOT part of the multi-enzyme complex of fatty acid synthase? O enoyl-ACP reductase O acetyl CoA carboxylase O 3-hydroxybutyrylACP-dehydratese O B-ketoacyl-ACP reductasearrow_forward
- X INCORRECT; see section 13.1 Enzymes occasionally display weak "“side" activities. Draw the structure of the product (other than ADP) of the reaction that results when pyruvate kinase, operating in reverse, uses lactate as a substrate. For your structure: 1. Do not include primary or secondary hydrogens. CH2 HO OH Edit Drawingarrow_forwardI'm confused about glycolysis and gluconeogenesis. Question: What is the function of glyceraldehyde 3-phosphate dehydrogenase? Is it because of -> The incorporation of a phosphate from ATP and reduction of glyceraldehyde 3-phosphate or ->The incorporation of phosphate from inorganic phosphate and reduction of glyceraldehyde 3-phosphate. or -> The incorporation of phosphate from inorganic phosphate and oxidation of glyceraldehyde 3-phosphatearrow_forwardWhat is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Group of answer choices Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductasearrow_forward
- Glucagon secretion inhibits intracellular acetyl-CoA carboxylase activity through a number of different methods. Make a list of everything that comes to mind.arrow_forwardAlthough both acetyl-CoA and succinyl-CoA are high-energy thioesters, their chemical energy is used in distinct ways. Elaborate.arrow_forwardTell me the pathway for thyroxine (how is it synthesized) So, how is thyroxine synthesized (it’s going to require the description of iodine) Don't copy from Googlearrow_forward
- What is the rate-limiting step in the synthesis of acetyl CoA? oxidation regeneration of lipoamide decarboxylation transfer to lipoamide transfer to CoAarrow_forwardThe energy yield for acetyl CoA in the fatty acid oxidation of a 16 carbon chain (16:0) is approximately: O 32 O 95 106 O 1.5arrow_forwardHO. Hexanoic acid is a 6-carbon saturated fatty acid found in goat's milk. Hexanoic acid also contributes to the "barnyard" smell of goats. Fun fact: Hexanoic acid is also known as caproic acid. The name "caproic" is derived from the Latin word "caper", which means goat. What is the balanced equation for complete beta oxidation of hexanoyl-COA to acetyl-CoA shown below (ignore H20 and H+): O Hexanoyl-COA + 3COA + 3FAD + 3NAD+ -------> 3 acetyl-COA + 3 FADH2 +3 NADH O Hexanoyl-CoA + 2COA + 2FAD + 2NAD+ --> 3 acetyl-CoA + 2 FADH2 + 2 NADH O Hexanoyl-CoA + 1COA + 1FAD + 1NAD+ --> 2 acetyl-CoA + 1 FADH2 +1 NADH O Hexanoyl-COA + 6COA + 6FAD + 6NAD+ --------> 6 acetyl-CoA.+ 6 FADH2 + 6 NADH None of the abovearrow_forward
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