Concept explainers
(a)
Interpretation:
The state (either oxidized or reduced) of
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(b)
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The way
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(c)
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The substrate type that
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(d)
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The form of
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(e)
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The general equation that includes
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- What coenzymes are required for the ββ-oxidation pathway? A) NAD+ and FAD only B) NAD+ and CoASH only C) CoASH only D) FAD and CoASH only E) FAD, NAD+, and CoASHarrow_forwarda) Write the general equation for cellular respiration. i) Based on the equation in 3a, what happen to the glucose and oxygen molecules during the redox reaction? Determine whether cellular respiration is an endergonic or exergonic process. Explain your answer. b) List the reactants and products for the process given i) Glycolysis. Reactants: Products (net): i) Citric acid cycle. Reactants: Products: c) How is ATP produced during Glycolysis and Citric acid cycle? d) Describe the process of ATP production by ATP synthase in oxidative phosphorylation.arrow_forwardIndicate whether the following statements are true or false:- a) The pentose phosphate pathway of glucose oxidation can lead to the release of energy. b) NAD + is a coenzyme of transketolase.arrow_forward
- In the complete b-oxidation of stearic acid (18:0), a) how many moles of acetyl CoA are produced? b) how many times would the fatty acid pass through the fatty acid spiral for complete oxidation? c) what is the total ATP produced in the citric acid cycle? d) how many moles of NADH are produced? e) how many moles of FADH2 are produced? f) how many moles of ATP are produced after all NADH are reoxidized in the respiratory chain? g) how many moles of ATP are produced after all FADH2 are reoxidized in the respiratory chain? h) how many moles of ATP are produced from the complete oxidation of stearic acid?arrow_forwardDetermine whether the following statements are true or false:- a) The pentose phosphate pathway of glucose conversion is a supplier of NADPH (H +) for reductive syntheses. b) An overdose of insulin causes hypoglycemia in a patient with diabetes mellitus. c) Fructose-6-phosphate is an allosteric regulator of glycolysis.arrow_forwardDiscuss the composition of the transition state for the formation of ATP by ATP Synthase. a) Where is the active site for this enzyme located? b) How are the amino acid side chains from the α and β subunits of ATP Synthase involved? c) Discuss the importance of Mg+2 in the mechanism of this enzyme.arrow_forward
- During the metabolism of glucose in anaerobic cells, the enzyme lactate dehydrogenase is essential to allow glycolysis to continue. This enzyme catalyzes the reduction of pyruvate to lactate. Why is this so essential? OA) It lowers the pH. B) It re-oxidizes NADH to NAD+. C) Lactate stimulates hexokinase activity. D) Pyruvate inhibits pyruvate kinase.arrow_forwardOligomycin is a substance that prevents the ATP synthesis reaction in oxidative phosphorylation, and 2,4-dinitrophenol is an uncoupling agent. In the presence of oligomycin, what would be the effect of adding 2,4-dinitrophenol? A) O2 consumption will increase. B) Electron transfer will be blocked. C) Oxidative phosphorylation will occur. D) Production of water will decrease.arrow_forwardWhich coenzyme is most often used in dehydrogenation reactions of the type –CH2CH2- = -CH=CH- ? a) NAD b) FAD c) NADP d) FMN Which one of these transports fructose? A) GLUT-2 b) GLUT-3 c) GLUT-4 d) GLUT-5 The pyruvate dehydrogenase complex converts pyruvate to which molecule? A) oxaloacetate b) glycogen c) acetyl-CoA d) citrate The pyruvate dehydrogenase complex produces how many ATP molecules at the substrate level? A) 0 b) 1 c) 3 d) 4 The pyruvate dehydrogenase complex produces how many ATP molecules indirectly via oxidative phosphorylation per glucose molecule? A) 1 b) 3 c) 5 d) over 30arrow_forward
- In the common catabolic pathway, a number of important molecules act as carriers ( transfer agents). a) which is the carrier of phosphate group? b) which are the core enzymes transferring hydrogen ions and electrons? c) what kind of group does core enzyme A carry?arrow_forwardUnder anaerobic conditions, Escherichia coli synthesizes an NADH-dependent fumarate reductase rather than succinatedehydrogenase, the flavoprotein that oxidizes succinate to fumarate. a) Write an equation for the reaction catalyzed by fumarate reductase.b) NADH produced by the glyceraldehyde-3-phosphate dehydrogenase reaction is re-oxidized by reducing an organicintermediate. Rather than reduce pyruvate to lactate, anaerobic E. coli utilize fumarate reductase. However, underanaerobiosis, the activity of -ketoglutarate dehydrogenase is virtually nonexistent. Show how fumarate is formed, usinga reaction beginning with PEP and including the necessary TCA cycle enzymes.c) What is the metabolic advantage to anaerobic E. coli in using the fumarate reductase pathway rather than lactatedehydrogenase to re-oxidize NADH?arrow_forwardIf a slight deficiency in the Vitamin B1 derivative Thiamine Pyrophosphate (TPP) leads to an accumulation of substrates for reactions utilizing this cofactor, A) what substrates would ‘accumulate’ in a human after eating a an enormous amount of sugar-laden Halloween candy, AND what would be the regulatory consequences on carbohydrate metabolism? B) what substrates would accumulate in yeast cells cultured under anaerobic (no oxygen) conditions AND what would be the regulatory consequences on carbohydrate metabolism? C) and lastly, what substrates would accumulate in plant cells incorporating carbon and generating energy solely using photosynthesis?arrow_forward
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