Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17.5, Problem 2COMQ
In the CRISPR-Cas system, what does the tracrRNA bind to?
a. crRNA and Cas1
b. crRNA and Cas2
c. crRNA and Cas9
d. Cas1 and Cas2
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Which of these statements is correct regarding the CRISPR/Cas9 system in eukaryotic cells?
a.Single guide RNA (sgRNA) is used to target specific DNA sequences and activate Cas.
b.Bacteriophages are used to inject viral genes into the cell to activated the Cas protein.
c.CRISPR takes advantage of the cell’s DNA polymerase proof-reading activities for DNA replication errors
d.The CRISPR-Cas system can only be used to alter genomes in prokaryotic cells.
e.Cas cuts directly into palindromic restriction sites that it targets in the DNA.
Which of these statements is correct regarding the CRISPR/Cas9 system in eukaryotic cells?
A.Single guide RNA (sgRNA) is used to target specific DNA sequences and activate Cas.
B.Bacteriophages are used to inject viral genes into the cell to activated the Cas protein.
C.CRISPR takes advantage of the cell’s DNA polymerase proof-reading activities for DNA replication errors
D.The CRISPR-Cas system can only be used to alter genomes in prokaryotic cells.
E. Cas cuts directly into palindromic restriction sites that it targets in the DNA.
1. a. CRISPR-Cas9 is a valuable biotechnology tool. Explain how this system uses RNA and the result of the interaction.
b. How is this different from miRNA?
Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- Which of the following statements regarding CRISPR is true? A. It is part of the innate immune system in prokaryotes. It is part of the innate immune system in eukaryotes. V B. c Jennifer Doudna's lab engineered the sgRNA to be two pieces. D. Jennifer Doudna's lab showed that CRISPR/Cas9 can be engineered to cleave at a specific DNA sequence. CRISPR can be used to introduce single or double DNA strand breaks. E.arrow_forwardWhat is the central component of a transcription initiation complex? a. DNA polymerase b. RNA polymerase c. DNA d. RNA e. RNAiarrow_forwardChoose the item in column 2 that best matches each item in column 1. A. Provides information for production of protein B. Binds to promoter C. Promoter has a box A and box B consensus sequences D. Autocatalytic RNA molecules E. Associated with transcription termination F. Polymerization of ribonucleotides to form RNA molecules G. 7-methyl guanosine H. MRNA prior to processing select - 1. Core RNA polymerase select 2. rho (p) factor select 3. hnRNA select - 4. RNA select -5. RNA polymerase holoenzyme select 6. Ribozymes select - 7. 5' MRNA cap select 8. MRNAarrow_forward
- The transcription initiation factor “recruited” together with RNA-Pol II in the formation of preinitiation complex is A. TFIIB B. TFIIH C. TFIIF D. TFIIAarrow_forwardIn RNA silencing, siRNAs and miRNAs usually bind to which part of the mRNA molecules that they control? a. 5′ UTR b. Coding region c. 3′ poly(A) tail d. 3′ UTRarrow_forwardHow can Cas9 technology be used in gene therapy. A. Base editing can be used to repair DNA error B. All 3 answers C. Cas9 can be used to activate transcription of a gene D. Knocking out a gene if it’s gain a function mutation is the cause of the diseasearrow_forward
- Describe the following a. Core enzyme RNA polymerase b. Sigma factor c. Promoter consensus sequence d. Rho Dependent Factor e. Intrinsic Factor f. Abortive Initiationarrow_forwardWhich eukaryotic RNA polymerase (RNA pol I,pol II, or pol III) transcribes which genes?a. tRNAsb. mRNAsc. rRNAsd. miRNAsarrow_forwardWhat is one function of TFIIH during transcription? a. Recruiting the TATA-box binding protein to the TATA-box. b. Terminating transcription via factor-dependent termination. c. Capping the 5' end of mRNA with 7-methylguanylate. d. Phosphorylating the CTD of RNA polymerase.arrow_forward
- What is the purpose of alternative splicing a. Alternative spiicing allows a protein to be included by multiple genes b. Alternative spicing allows for mutations to accumulate that won't affect the expression of a gene c. Alternative splicing allows for multiple mRNAs to be produced to ensure that the single proteins the gene and codes will be translated. d.arrow_forwarda. What is grey donut shaped object supposed to represent? b. Label with the word "promoter" where one might find the promoter region in this image. c. In the magnified insert, label the template strand that is being transcribed with the word "template". d. In the magnified insert label the 5' and 3' ends of the transcript. e. What entity functions to break the complementary base pairing of a gene at its transcription start site? CS Scanned with CamScannerarrow_forwardWhat binds to the -10 consensus sequence found in most bacterial promoters? a. The holoenzyme (core enzyme + sigma factor) b. The sigma factor alone c. The core enzyme alone d. mRNAarrow_forward
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