Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17.4, Problem 1COMQ
Which of the following is a function of SRP?
a. Pausing translation of polypeptides with an ER signal sequence
b. Binding to an SRP receptor in the ER membrane
c. Docking the ribosome over a channel
d. All of the above
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Students have asked these similar questions
1. The SRP is recognized by the SRP receptor.
2. The ribosome translates the protein through the translocon and into the ER lumen.
3. The ribosome attaches to the translocon.
4. Chaperones assist in the proper folding of the protein.
5. The signal peptide on the nascent polypeptide is synthesized by the ribosome and recognized by
the SRP (signal recognition protein).
A. 5, 3, 1, 2, 4
OB. 1, 5, 4, 3, 2
C. 5, 1, 3, 2, 4
OD. 1, 2, 3, 4, 5
E. 1, 5, 3, 2, 4
QUESTION 32
The side of the Golgi stack orientated towards the endoplasmic reticulum is the
OA.
cis-Golgi network
B. trans-Golgi network
OC. vesicle
OD. medial-Golgi
QUESTION 33
Which molecule is displaced when a vesicle and its target membrane fuse?
A. Water
OB. Cholesterol
OC. Phospholipids
D. DNA
OE. SNARES
2.
2.
Which of the following is true of ribosome rescue? (C & E wrong)
A. The process produces a protein that is tagged for degradation.
B. Proteases enter the A-site of the ribosome to degrade the C-terminus of the synthesized peptide.
C. A partially translated mRNA becomes fully degraded before it can be translated further.
D. No protein is produced in the process.
E. Stalled ribosomes are released in the absence of a stop codon.
1)You add a drug to cells that can pass through hydrophilic or hydrobic environments (e.g., membranes & cytosol). The drug specifically prevents the binding of KDEL (ER retention signal) to any other molecules. In the short term, what would happen to the synthesis and localization of translocon proteins?
a. New complete translocon proteins would be made, but they would end up in the golgi apparatus.
b. New complete translocon proteins would be made, but they would end up at the plasma membrane
c. No new intact translocon proteins would be synthesized
d. New complete translocon proteins would be made, but they would be secreted
e. New complete translocon proteins would be made and localized normally
Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- The SecB protein helps export proteins by: Explain the answer and choice the right one a.binding signal peptides for appropriate targeting b.acting as a chaperone to prevent protein folding c.cleaving signal peptides for appropriate protein folding d.acting as a chaperone to promote protein foldingarrow_forwardDefine the following terms:a. SRPb. transloconc. docking proteind. SRP receptor proteine. signal peptidasearrow_forwardYou genetically engineered a cell to no longer contain the extracellular domain of an integrin. What is the most likely effect of losing this domain on the cell's ability to bind? A It would affect the cell's ability to attach to the ECM. B It would have no effect on the cell's ability to attach to anything. C It would affect the cell's ability to attach to the cytoskeleton through adaptor proteins. D It would affect both the cell's ability to attach to other cells and the cell's ability to attach to the cytoskeleton.arrow_forward
- Much of procollagen formation occurs in the endoplasmic reticulum and Golgi apparatus which requires signal peptide. All of the following statements about targeting a protein for the ER are true except A. signal peptide usually has a positively charged N-terminus and a stretch of hydrophobic amino acids. B. signal peptide emerging from a free ribosome binds signal recognition particle (SRP). C. signal peptide is usually cleaved from the protein before the protein is inserted into the ER membrane. D. docking protein is actually an SRP receptor and serves to bind the SRP to the ER. E. SRP and docking protein do not enter the ER lumen but are recycled.arrow_forwardWhich of the following statements about ribosomes is correct? * a. the number of ribosomes in a cell seldom exceeds 50 b. the active site of a ribosome contains mostly protein molecules c. structurally, ribosomes have two rRNA- protein subinuts d. no correct response What is the complementary hnRNA base sequence produced from the DNA base sequence 5' C-T-A-T-A-C 3' ? * a. 3' C-T-A-G-A-T 5' b. 3' C-G-G-A-T-A 5' c. 3' G-A-U-A-U-G 5' d. 3' G-A-T-A-T-G 5' The product of the first phase in protein synthesis is * a. DNA molecules b. RNA molecules c. both RNA and DNA molecules d. neither RNA and DNA moleculesarrow_forwardWhat kind of domain is involved with intracellular signaling, cytoskeleton remodeling, and are able to bind phosphoinositides with both high affinity and specificity? A. SH2 B. SH1 C. PH D. None of the answers are correct E. SH3 F. Either SH1 or SH2arrow_forward
- Define the following terms:a. decoding centerb. peptidyl transferase centerc. GTPase-associated centerd. guanine nucleotide exchange factore. proton shuttle mechanismarrow_forwardThe “A” site in the ribosome refers to the: A. binding site for charged t-RNA molecules during protein synthesis B. Site that allows for tRNAs to exit C. a site that holds the tRNA which is linked to the growing polypeptide chain D. none of these answeresarrow_forwardHypertrophic cardiomyopathy is caused by mutations in the β-myosin heavy chain gene. One common mutation involves a change of an arginine (Arg) to a glutamine (Gln) at position 403. Using the genetic code shown above, what could the sequence of the mutant codon be? a. CAA b. CGA c. CGG d. CACarrow_forward
- The SRP receptor functions in the ER membrane. Which answer best describes its translation process and movement to destination for function?arrow_forwardWhich of the following is most likely to have a small protein called ubiquitin attached to it? A. a cell surface protein that requires transport from the ER B. a regulatory protein that requires sugar residues to be attached -C. an mRNA that is leaving the nucleus to be translated D. a protein that has lost a disulphide bond stabilizing its 3-dimensional structure, causing it to misfoldarrow_forwardA rare mutation can result in eukaryotic cells that causes a failure in the cell to synthesize the Signal Recognition Particle (SRP). Failure to make the SRP would impact protein synthesis by ________ . A. Preventing transition of bound ribosomes to free ribosomes B. Preventing binding of ribosomes to the rough ER during synthesis of proteins with a signal sequence C. Preventing export of mRNA out of the nuclear envelope D. Preventing binding of ribosomes to the smooth ER during synthesis of proteins with a signal sequencearrow_forward
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