Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17, Problem 4CONQ
Explain how HOTAIR plays a role in the transcriptional regulation of particular genes.
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Compare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.
Discuss how the expression of a protein can be regulated post transcription in eukaryotic cells through, using the following key terms:
Degradation of mRNA (two ways)
Blocking translation
Degradation of the protein
Explain how a transcriptional fusion to a reporter gene, combined with site directed mutagenesis,
can indicate key nucleotides in a regulatory region. Name one in vitro technique that can be used to
further confirm the significance of these regions.
Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.arrow_forwardExplain how iRNA works to down-regulate gene expression.arrow_forwardRegulation can occur at many steps in the pathway of gene expression. Briefly describe at least one example of a regulator at the level of: a) transcriptional initiation b) protein stability c) posttranslational protein modificationarrow_forward
- Discuss the advantages and disadvantages of genetic regulation at the different points identified.arrow_forwardPlease explain the critical role of TFIID in the initiation of eukaryotic transcription?arrow_forwardNegative supercoiling of DNA favors the transcription of genes because it facilitates unwinding. However, not all promoter sites are stimulated by negative supercoiling. The promoter site for topoisomerase II itself is a noteworthy exception. Negative supercoiling decreases the rate of transcription of this gene. Propose a possible mechanism for this effect and suggest a reason why it may occur.arrow_forward
- Answer these questions concerning promoters. a) What role do promoters play in transcription? b) What is the common structure of bacterial promoter with respect to consensus sequences? c) Eukaryotic promoters are more variable than bacterial promoters. Why? d) What is the meaning of the term alternative promoter? How does the use of alternative promoters affect transcription?arrow_forwardWhat is meant by the term transcription factor modulation? List three general ways this can occur.arrow_forwardExplain how the ncRNA known as HOTAIR plays a role in gene repression.arrow_forward
- Please describe the regulatory role of enhancers that binds to responsible regulators to activate the target gene at a given time and place through comparing different organisms according to the presence of regulatory sequencesarrow_forwardplease explain how does INRNA modify the structure of the chromatin in order to regulate gene ww w w expression?arrow_forwardDiscuss in general terms the principle of the regulation of theexpression of the trp gene with attenuation in bacteria.arrow_forward
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