Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 17, Problem 18P
Summary Introduction
To analyze:
Pedigree given in which many members of family show symptoms of mitochondrial disease MERRF. Analyze the chance of
Introduction:
In sexually reproducing organisms like mammals, the egg cell usually destroys the sperm after fertilization. The contribution from a diploid zygote is only haploid set of chromosomes. The Fetus receives other the cellular components from the mother’s side (Egg). Thus, the diseases related to mitochondria are maternally inherited. Mitochondrial disease is not passed to the next generation from the paternal side.
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The following pedigree shows the inheritance of a mutation that causes the mitochondrial disease MERFF. Below each individual who carries the mutation is the level of
severity of the disease (mild, moderate, or severe).
I
mild
ооо
mild moderate
moderate severe
mild
Which of the following statements likely explain this observation? (Select all correct answers.)
Individual 1.1 is heteroplasmic for the mutation that causes MERFF
Individual 1.1 is homoplasmic for the mutation that causes MERFF
Individual 1.1 is homozygous for the mutation that causes MERFF
This is a typical pedigree for a family that carries neurofibromatosis.
Is individual I-2 most likely homozygous or heterozygous? Why? Explain.
The following pedigree illustrates the inheritance of Nance–Horan syndrome, a rare genetic condition in which affected people have cataracts and abnormally shaped teeth.
Chapter 17 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 17 - 17.1 Reciprocal crosses of experimental animals or...Ch. 17 - 17.2 How are some of the characteristics of the...Ch. 17 - 17.3 The human mitochondrial genome encodes...Ch. 17 - What is the evidence that transfer of DNA from the...Ch. 17 - Draw a graph depicting the relative amounts of...Ch. 17 - Prob. 6PCh. 17 - 17.7 What is the evidence that the ancient...Ch. 17 - 17.8 Outline the steps required for a gene...Ch. 17 - 17.9 Consider the phylogenetic tree presented in...Ch. 17 - You are a genetic counselor, and several members...
Ch. 17 - A mutation in Arabidopsis immutans results in the...Ch. 17 - What type or types of inheritance are consistent...Ch. 17 - You have isolated (1) a streptomycin-resistant...Ch. 17 - You have isolated two petite mutants, pet1 and...Ch. 17 - 17.15 Consider this human pedigree for a vision...Ch. 17 - A 50- year - old man has been diagnosed with MELAS...Ch. 17 - 17.17 The first person in a family to exhibit...Ch. 17 - Prob. 18PCh. 17 - 17.19 What is the most likely mode of inheritance...Ch. 17 - 17.20 In , the Russian Tsar Nicholaswas deposed,...Ch. 17 - 17.21 The dodo bird (Raphus cucullatus) lived on...Ch. 17 - Cytoplasmic male sterility (CMS) in plants has...Ch. 17 - 17.23 Wolves and coyotes can interbreed in...Ch. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Most large protein complexes in mitochondria and...Ch. 17 - As described in this chapter, mothers will pass on...
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- A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C. If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?arrow_forwardThe following pedigree illustrates the inheritance of a rare neurologicaldisease. What is the most likely mode of inheritance for this disorder?Explain your reasoning.arrow_forwardWhich of the pedigrees shown above could be one showing the inheritance of a non-lethal mitochondrial disease?arrow_forward
- Kate and her husband are both heterozygous for galactosemia gene. If Kate and her husband have four children, how many of their children are likely to have galactosemia?arrow_forward152 Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. If they have a normal child, what is the probability that he or she will be heterozygous? If they have three children, what is the probability of having 2 affected children and one normal child?arrow_forwardFrom the pedigree in Figure 3-25, what principle can youdeduce about the inheritance of mitochondrial diseasefrom affected fathers?arrow_forward
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