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As described in this chapter, mothers will pass on a mitochondrial defect on their offspring. In a type of gene therapy, one approach to circumvent this problem is to have two different matrernal contributions, with the nucleus of the female with the defective mitochondria being placed in an enucleated egg derived from a female with normal mitochondria. After fertilization, the resulting offspring would have three parental sources of DNA
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Genetic Analysis: An Integrated Approach (3rd Edition)
- Antibiotics such as chloramphenicol, tetracycline, and erythromycin inhibit protein synthesis in bacteria, but have no effect on the synthesis of proteins encoded by eukaryotic nuclear genes. Cycloheximide inhibits the synthesis of proteins encoded by nuclear genes, but has no effect on bacterial protein synthesis. How might these compounds be used to determine which proteins are encoded by mitochondrial and chloroplast genomes?arrow_forwardThe mitochondrial genome of Chlamydomonas contains the lowest number of genes, 12, of all the species of green algae. However, only 7 proteins are produced inside these mitochondria. Which of the following statements is the best explanation for why only 7 proteins are made from the 12 genes In Chlamydomonas mitochondria? OA Five of the genes are redundant; another copy is expressed from the nuclear genome.. OB. Five of the genes are nonfunctional "pseudogenes". OC Five of the genes are transcribed, but not translated. OD. Five of the genes are coding for proteins that are translated in the cytoplasm. Reset Selectionarrow_forwardIf you expose a culture of human cells (for example,HeLa cells) to 3H-thymidine during S phase, howwould the radioactivity be distributed over a pair ofhomologous chromosomes at metaphase? Would theradioactivity be in (a) one chromatid of one homolog,(b) both chromatids of one homolog, (c) one chromatid each of both homologs, (d) both chromatids ofboth homologs, or (e) some other pattern? Choose thecorrect answer and explain your reasoning.arrow_forward
- Hundreds of DNA double strand breaks are created by SPO11, a topoisomerase type II like protein. (i) Draw and explain how SPO11 can generate double strand breaks. (ii) What would be the consequences to the outcome of meiosis if SPO11 is absent? Explain your reason.arrow_forwardA cytogeneticist is studying the cells from an abnormal female monkey. In some cells, she finds that both X-chromosomes are active (i.e. not packaged into a Barr body), although one of the X-chromosomes appears shorter. She also finds that one of the autosomes are packaged as a Barr body, and she suspects that a translocation event might have been involved. By referring to the mechanism of X-chromosome inactivation, explain the observations made by the scientistarrow_forwardIn a germline progenitor cell before DNA replication (2N), a translocation occurred between a telocentric and submetacentric chromosome resulting in a translocation heterozygote. The location of the translocation is illustrated below. Draw the Prophase I pairing conformation that would result from this translocation. The four types of chromosomes you have now can be labeled as follows: T-WT (telocentric wild type), T-TL (telocentric translocation), SM-WT (submetacentric wild type), and SM-TL (submetacentric translocation). Using these labels, list (please do not draw) the possible outcomes of Anaphase I and the possible phenotypes for each outcome. Please explain your reasoning for each phenotype in a few words. asaparrow_forward
- According to the endosymbiosis theory, mitochondria and chloroplasts are derived from bacteria that took up residence withineukaryotic cells. At one time, prior to being taken up by eukaryoticcells, these bacteria were free-living organisms. However, we cannot take a mitochondrion or chloroplast out of a living eukaryoticcell and get it to survive and replicate on its own. Discuss why not.arrow_forwardA somatic cell has the genotype DdEe. All chromosomes in this organism are metacentric. Show metaphase and the results of mitosis if the D and E locus are linked on the same chromosome in trans configuration. A sexually reproducing organism has the following phenotype DdEeAaTt: The D and E loci are on the same arm of a metacentric chromosome in cis configuration. The A locus is on the long arm of an acrocentric chromosome and the T locus is on a telocentric chromosome. 2.1. What is the haploid number of this organism? 2.2. Using diagrams show a ceii at metaphase of mitosis and show the results of mitosis.arrow_forwardThe Yellow Fever vector mosquito (Aedes Aegypti) is normally 2n = 8. Please draw the following diagrams and in each of your diagrams label the following (or note the absence of): a) a pair of homologous chromosomes b) a pair of sister chromatids A) A somatic cell in this organism undergoing prophase. B) A germ cell undergoing anaphase II.arrow_forward
- What difference exists between the compaction of chromosomes during metaphase versus interphase? Give at least one reason why this difference may be necessary.arrow_forwardThe oncogenic protein BETA promotes entry into the S phase of the cell cycle. Phosphorylation of BETA at the amino acid Tyr98 causes BETA to be degraded by the proteasome, thus limiting its abundance. A mutation in the codon encoding Tyr98 changes this residue to Cys, which cannot be phosphorylated. What is the best description of this mutant allele?a) antimorphb) hypermorphc) hypomorphd) amorphe) neomorpharrow_forwardWhy is a chromosomal fragment without a centromeresubsequently lost and degraded?arrow_forward
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