Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 14, Problem 3TQ
Summary Introduction
To review:
The components of the ETS (electron transport system) in the pathogen that will make good targets for antibiotics.
Introduction:
Antibiotics are medicines that help fight infections caused by bacteria. They either kill or inhibit the growth of bacterial cells. Originally, it is a substance produced by one microorganism that affects the growth of another microorganism. The plasmid carries the genes responsible for antibiotic resistance in the bacterial cells.
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Give two reasons why bacteria are becoming more and more resistant to antibiotics.
Some antibiotics fail to kill/inhibit a pathogen simply because the microbe is naturally (intrinsically) resistant to it.
True or False ?
Introduction: There’s quite a bit of interest around repurposing extant drugs to treat infections by targeting host pathways that pathogens rely on. Here are a few potential drugs:
1) A drug that inhibits endocytosis, but not phagocytosis. 2) A drug that inhibits degradation of cytoplasmic proteins into smaller peptides, preventing their cycling back into amino acids. 3) A drug used to treat porphyria that reduces the reactivity of heme. 4) A drug that depletes glutathione, a chemical which protects red blood cells against the reactivity of heme. 5) A drug that reduces expression of the ACE-2 protein.
Question: Pick a drug and an infection that the drug is likely to be good at treating, or pick an infection and a drug that would most likely make the infection substantially worse. Which drug and pathogen did you pick? Do you think it’ll make it better or worse?
Chapter 14 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 14.1 - Prob. 1TQCh. 14.1 - Prob. 2TQCh. 14.2 - Prob. 1TQCh. 14.2 - Prob. 2TQCh. 14.2 - Prob. 3TQCh. 14.3 - Prob. 1TQCh. 14.3 - Prob. 2TQCh. 14.3 - Prob. 3TQCh. 14.4 - Prob. 1TQCh. 14.5 - Prob. 1TQ
Ch. 14.5 - Prob. 2TQCh. 14.6 - Prob. 1TQCh. 14 - Prob. 1RQCh. 14 - Prob. 2RQCh. 14 - Prob. 3RQCh. 14 - Prob. 4RQCh. 14 - Prob. 5RQCh. 14 - Prob. 6RQCh. 14 - Prob. 7RQCh. 14 - Prob. 8RQCh. 14 - Prob. 9RQCh. 14 - Prob. 10RQCh. 14 - Prob. 11RQCh. 14 - Prob. 1TQCh. 14 - Prob. 2TQCh. 14 - Prob. 3TQCh. 14 - Prob. 4TQ
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- Which feature (antibiotic target) of bacteria seems to be the most resistant to antibiotics? Why might that be?arrow_forwardBecause of overuse of antibiotics and/or weakened governmental surveillance of infectious disease, several diseasesthat had been thought to be no longer a threat to humanhealth (e.g., pneumonia and tuberculosis) are rapidly becoming unmanageable. In several instances, so-called superbugs(microorganisms that are resistant to almost all known antibiotics) have been detected. How did this circumstancearise? What will happen if this process continues?arrow_forwardWhat are drug resistant pathogens? What are three different molecular mechanisms an organism might develop resistance or be resistant ?arrow_forward
- Define/Explain What are antibiotics?arrow_forwardIn the mid-1990s, researchers discovered an enzyme in HIV called protease. Once the enzyme's structure was known, researchers began developing drugs that fit into the active site and blocked it. This strategy for stopping HIV infections is an example of what phenomenon? OA) feedback regulation OB) competitive inhibition OC) immunization OD) allosteric regulationarrow_forwarddescribe three ways in which bacteria may develop resistance to antibiotics.arrow_forward
- Some antibiotics are effective against only a limited range of organisms. What is a term you learned in the virtual lab that is used to describe this phenomenon and describe what it means.arrow_forwardWhy are the risks associated with antibiotics hard to understand? Please describe in detail with reasoning in a supporting paragraph.arrow_forwardWhat is a relevant biological process that can be used to briefly explain or illustrate the risks associated with antibiotics?arrow_forward
- In terms of microbial pathogenicity, molecular Koch's postulates are a set of experimental criteria that show: A microbe is the aetiological agent of a disease A gene encodes a product that contributes to disease A gene encodes a product that contributes to immunity to a disease A mutation does not contribute to diseasearrow_forwardWith the help of two examples , define antibiotics?arrow_forwardExplain what are antibiotics?arrow_forward
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USMLE-Rx Antimicrobial Therapy; Author: USMLE-Rx;https://www.youtube.com/watch?v=Pka1Ynlrqtw;License: Standard Youtube License