The construction of lentivector in gene therapy to avoid virus replication. Introduction: Gene therapy is the technique that is designed to introduce genes to treat or to prevent diseases by replacing the disease-causing gene with a healthy copy of the gene. In gene therapy, genes are used to treat the disease instead of drugs. The gene of interest is transported from one organism to the other by means of a vector. The viruses that establish their replication cycle in the host nucleus are also used to transport the gene of interest.

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Chapter 11, Problem 8RQ

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The construction of lentivector in gene therapy to avoid virus replication.

Introduction:

Gene therapy is the technique that is designed to introduce genes to treat or to prevent diseases by replacing the disease-causing gene with a healthy copy of the gene. In gene therapy, genes are used to treat the disease instead of drugs. The gene of interest is transported from one organism to the other by means of a vector. The viruses that establish their replication cycle in the host nucleus are also used to transport the gene of interest.

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15) Why are viruses an ideal candidate for gene delivery in gene therapy? a) What are TWO limitations of viruses as gene delivery vectors in gene therapy?

Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.

What enzyme is required for the movement of transposable elements that involve an RNA intermediate in virus? options: RNA polymerase reverse transcriptase polyA polymerase peptidyl transferase