Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 8, Problem 34CONQ
Summary Introduction
To review:
The possible number of chromosomes in mother and father having a daughter with familial Downsyndrome(46 chromosomes) and a son who is phenotypically affected (45 chromosomes).
Introduction:
The process in which a piece of one chromosome detaches itself and gets attached to another chromosome is known as translocation. Translocation can be of two types, namely, balanced and unbalanced translocations. Balanced translocation does not cause any change in the amount of genetic material. Unbalanced translocation is the one wherein the exchange of the chromosomal material is unequal leading to an extra or missing number of genes.
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The karyotype of a young girl who is affected with familialDown syndrome revealed a total of 46 chromosomes. Her olderbrother, however, who is phenotypically unaffected, actually had45 chromosomes. Explain how this could happen. What wouldyou expect to be the numbers of chromosomes in the parents ofthese two children?
A boy with Down syndrome (trisomy 21) has 46 chromosomes. One parent and his two older sisters have a normal phenotype, but each have 45 chromosomes.
a)Explain how this is possible.
b)How many chromosomes do you expect to see in karyotypes of the parents?
c)What term best describes this kind of chromosome abnormality?
d)What is the probability the next child of this couple will have a normal phenotype and have 46 chromosomes? Explain your answer.
A normal mother has translocations on chromosomes 14:21. With respect to chromosomes 14:21, how many combinations of chromosomes are possible? How many gametes are viable?
If the woman has children with an normal father, what is the probability that there is a daughter with Down Syndrome or a son with an unaffected phenotype?
Chapter 8 Solutions
Genetics: Analysis and Principles
Ch. 8.1 - 1. A chromosome that is metacentric has its...Ch. 8.1 - Staining eukaryotic chromosomes is useful because...Ch. 8.2 - Prob. 1COMQCh. 8.3 - Which of the following statements is correct? a....Ch. 8.3 - Prob. 2COMQCh. 8.4 - 1. A paracentric inversion
a. includes the...Ch. 8.4 - Due to crossing over within an inversion loop, a...Ch. 8.4 - 3. A mechanism that may cause a translocation is...Ch. 8.5 - 1. Humans have 23 chromosomes per set. A person...Ch. 8.6 - Prob. 1COMQ
Ch. 8.6 - Prob. 2COMQCh. 8.7 - The term endopolyploidy refers to the phenomenon...Ch. 8.7 - 2. In agriculture, an advantage of triploidy in...Ch. 8.8 - Prob. 1COMQCh. 8.8 - The somatic cells of an allotetraploid contain a....Ch. 8 - 1. Which changes in chromosome structure cause a...Ch. 8 - Prob. 2CONQCh. 8 - 3. How does a chromosomal duplication occur?
Ch. 8 - 4. What is a gene family? How are gene families...Ch. 8 - Prob. 5CONQCh. 8 - Two chromosomes have the following orders for...Ch. 8 - An inversion heterozygote has the following...Ch. 8 - Prob. 8CONQCh. 8 - Explain why inversions and reciprocal...Ch. 8 - 10. An individual has the following reciprocal...Ch. 8 - A phenotypically normal individual has the...Ch. 8 - 12. Two phenotypically normal parents produce a...Ch. 8 - With regard to the segregation of centromeres, why...Ch. 8 - Prob. 14CONQCh. 8 - Prob. 15CONQCh. 8 - 16. A phenotypically abnormal individual has a...Ch. 8 - 17. A diploid fruit fly has eight chromosomes. How...Ch. 8 - Prob. 18CONQCh. 8 - Prob. 19CONQCh. 8 - 20. Aneuploidy is typically detrimental, whereas...Ch. 8 - 21. Explain how aneuploidy, deletions, and...Ch. 8 - Prob. 22CONQCh. 8 - 23. A cytogeneticist has collected tissue samples...Ch. 8 - Prob. 24CONQCh. 8 - A zookeeper has collected a male and a female...Ch. 8 - Prob. 26CONQCh. 8 - 27. What is mosaicism? How is it produced?
Ch. 8 - 28. Explain how polytene chromosomes of Drosophila...Ch. 8 - 29. Describe some of the advantages of polyploid...Ch. 8 - 30. While conducting field studies on a chain of...Ch. 8 - Prob. 31CONQCh. 8 - Which of the following terms should not be used to...Ch. 8 - Prob. 33CONQCh. 8 - Prob. 34CONQCh. 8 - A triploid plant has 18 chromosomes (i.e., 6...Ch. 8 - Prob. 36CONQCh. 8 - Prob. 37CONQCh. 8 - 38. A woman who is heterozygous, Bb, has brown...Ch. 8 - 39. What is an allodiploid? What factor determines...Ch. 8 - Prob. 40CONQCh. 8 - 41. Table 8.1 shows that Turner syndrome occurs...Ch. 8 - 42. Male honeybees, which are haploid, produce...Ch. 8 - Prob. 1EQCh. 8 - Prob. 2EQCh. 8 - With regard to the analysis of chromosome...Ch. 8 - 4. Describe how colchicine can be used to alter...Ch. 8 - 5. Describe the steps you would take to produce a...Ch. 8 - Prob. 6EQCh. 8 - What are G bands? Discuss how G bands are useful...Ch. 8 - A female fruit fly has one normal X chromosome and...Ch. 8 - Prob. 2QSDCCh. 8 - Besides the ones mentioned in this textbook, look...Ch. 8 - Prob. 4QSDCCh. 8 - 5. Discuss the importance of gene families at the...
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- The ABO blood type locus has been mapped on chromosome 9. A father who has type AB blood and a mother who has type O blood have a child with trisomy 9 and type A blood. Can you tell in which parent the non disjunction occurred? Explain.arrow_forwardGiven the following genetic map, predict the chance an offspring would inherit the exact same haplotypes that the parents had. Assume interference in this area of the chromosome is 5%. Please report your value as a percent (%). A |-- 3 mu -- |-- 12 mu -- | Parent 1 Haplotypes: A1 B6 C14/A5 B1 C3 Parent 2 Haplotypes: A8 B3 C2 / A7 B2 C5arrow_forwardThe karyotype of a young girl who is affected with Down syndrome revealed that she has 46 chromosomes. Her phenotypically normal older brother's karyotype revealed that he has 45 chromosomes. (a) Propose an explanantion for the chromosome number in both children (b) What would you expect the chromosome number of the parents of these two children?arrow_forward
- A phenotypically normal individual has the following combinations of normal and abnormal chromosomes:The normal chromosomes are shown on the left in each pair.Suggest a series of events (breaks, translocations, crossovers, etc.)that may have produced this combination of chromosomes.arrow_forwardA man who is a carrier of a translocated 15/21 chromosome marries a genotypically normal woman. (1). Show the possible gametes that will be formed by this man if the translocated 15/21 chromosome synapses with chromosome 21 at Prophase I. (2). What is the probability that the first child of the couple will be a phenotypically normal girl? (3). What is the probability that the first child of the couple will be a genetically normal boy?arrow_forwardTwo phenotypically normal parents produce a phenotypically abnormal child in which chromosome 5 is missing part of its long arm but has a piece of chromosome 7 attached to it. The child also has one normal copy of chromosome 5 and two normal copies of chromosome 7. With regard to chromosomes 5 and 7, what do you think are the chromosomal compositions of the parents? Would it most likely be reciprocal translocation? It wouldn't be simple translocation because then the child would have the entirety of one chromosome and only some of the other, but in this case, there is only partial chromosome 5 and chromosome 7?arrow_forward
- Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?arrow_forwardwhat is the significance of chromosomal aberration? what are the different types of chromosomal abberations based on the structure and number of chromosomes? give examples for each. what environmental factors may increase in the incidence of chromosomal aberrations?arrow_forwardIn a college genetics laboratory course, a healthy student constructs a karyotype from a cell from inside her cheek. She finds only one chromosome 3 and one chromosome 21, plus two unusual chromosomes that do not seem to have matching partners. a. What type of chromosomal abnormality does she have? b. Why doesn’t she have any symptoms? c. Would you expect any of her relatives to have particular medical problems?arrow_forward
- A phenotypically normal woman has an abnormally structured chromosome 2, along with a normal homologue. She marries a phenotypically normal man with an abnormally structured chromosome 16 and a normal homologue. What is the probability of their child will have an abnormal chromosome 2 and 16? What is the probability that this child, having inherited both abnormal chromosomes, will now pass both abnormal chromosomes to its children?arrow_forwardA cytogeneticist has collected tissue samples from members of a certain butterfly species. Some of the butterflies were located in Canada, and others were found in Mexico. Through karyotyping, the cytogeneticist discovered that chromosome 5 of the Canadian butterflies has a large inversion compared with chromosome 5 of the Mexican butterflies. The Canadian butterflies were inversion homozygotes, whereas the Mexican butterflies had two normal copies of chromosome 5. 1) Would a cross between Mexican and Canadian butterflies produce phenotypically normal offspring? and 2) Would the offspring of the cross (so F2 generation) be fertile?arrow_forwardThis is a typical pedigree for a family that carries neurofibromatosis. Is individual I-2 most likely homozygous or heterozygous? Why? Explain.arrow_forward
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