Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Textbook Question
Chapter 8, Problem 19P
Suggest the effects of each of the following mutations on the physiological role of chymotrypsinogen:
a. R15S
b. C1S
c. T147S
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Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147S
. Suggest the effects of each of the following mutations on the physio-
logical role of chymotrypsinogen:
(a) R15S
(b) Cis
(c) T147S
Hydroxyurea has been shown to increase the expression of fetal hemoglobin in adult red blood cells, by a mechanism that remains unclear. Explain why hydroxyurea can be a useful therapy for patients with sickle-cell anemia.
Chapter 8 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 8 - Prob. 1PCh. 8 - The enzyme urease catalyzes the hydrolysis of urea...Ch. 8 - An enzyme contains an active site aspartic acid...Ch. 8 - The folding and unfolding rate constants for a...Ch. 8 - In some reactions, in which a protein molecule is...Ch. 8 - Would you expect an “enzyme” designed to bind to...Ch. 8 - The initial rate for an enzyme-catalyzed reaction...Ch. 8 - a. If the total enzyme concentration in Problem 7...Ch. 8 - Prob. 9PCh. 8 - Prob. 10P
Ch. 8 - The following data describe the catalysis of...Ch. 8 - At 37 oC, the serine protease subtilisin has kcat...Ch. 8 - The accompanying figure shows three...Ch. 8 - The steady-state kinetics of an enzyme are studied...Ch. 8 - The same enzyme as in Problem 14 is studied in the...Ch. 8 - Enalapril is an anti-hypertension “pro-drug"...Ch. 8 - Initial rate data for an enzyme that obeys...Ch. 8 - Prob. 18PCh. 8 - Suggest the effects of each of the following...Ch. 8 - The inhibitory effect of an uncompetitive...Ch. 8 - Prob. 21PCh. 8 - Prob. 22PCh. 8 - Prob. 23PCh. 8 - In kinetics experiments, the hydrolysis of the...
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- Explain the regulatory processes of purine synthesis that would result in an increase in the concentration of GMP.arrow_forwardA series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole ترف لي تي في R= -NHarrow_forwardTPCK and TLCK are irreversible inhibitors of serine proteases. One ofthese inhibits trypsin and the other chymotrypsin. Which is which? Explainyour reasoning. Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147Sarrow_forward
- ABC is an oral medicine and is a co-formulation containing Drug X and Drug Z. When administered alone, Drug X which is the active ingredient, exhibits poor bioavailability. Drug X is known to be metabolised by hepatic CYP enzymes. Studies have shown that addition of Drug Z results in higher blood levels of Drug X. 1) How this might be possible ? 2) Predict possible changes to the pharmacokinetic parameters of Drug X when co-administered with Drug Z ? 3) Clinical outcomes brought about by using this co-formulation ABC ?arrow_forwardDraw the structures of the major metabolites you would predict (Phase I and Phase II) for the non-steroidal anti-inflammatory drug naproxen and the beta blocker propranolol (use hand drawn illustrations or free chemistry drawing software, e.g. Marvin, for your answer). Explain how these metabolites are formed and comment on the role of metabolism (Phase I and Phase II) in the detoxification of the drugs.arrow_forwardDiscuss the biosynthesis of epinephrine. Give one important medical use of epinephrine.arrow_forward
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