The plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) areshown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine;C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data isshown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain howyou know this from the profiles? (B) Is this a problem for cough suppression? Explain.-CHHOCodeineCOD10 0001000C6GCOD100M3GM6GNM10M102030 0102030Plasma concentration (nmol I-)

Drugs administered through oral route are metabolized in the body. Some drugs become inactivated…

shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data i shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain you know this from the profiles? (B) Is this a problem for cough suppression? Explain.

shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data i shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain you know this from the profiles? (B) Is this a problem for cough suppression? Explain.

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.7P

See similar textbooks

Similar questions

A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole ترف لي تي في R= -NH
Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147S
One general guideline for the maintenance dosing of heparin in pediatric patients is 100 units/kg every4 hours, or 20,000 units/m²/24 hour administered continuously. The a vailable injection for use by intravenous infusion contains 1000 USP Heparin Units/mL For a 44-lb child, measuring 42 inches in height, calculate the difference between the quantities of heparin administered over a 24-hour period in (a) heparin units, (b) in milligrams of heparin (sod ium), and (c) in milliliters of heparin injection.
Kindly mention the indications for clopidogrel in acute coronary syndrome (ACS). Should it be used along with aspirin or alone if the latter is contraindicated? Are there any studies that combine both with either low-molecular-weight heparin (LMWH) or unfractionated heparin? How long should clopidogrel be continued?
The hexapeptide Ala-Met-Leu-Lys-Phe-Asp is digested in the same tube with both Cyanogen Bromide and Trypsin at the same time at pH=7. Draw the structure of the product(s) that would bind to a cation exchange column. (Relevant pKa values are 2.2, 3.9, 9.5 and 10.5. Assume pKa values for any newly generated a-amino and a-carboxyl groups are 9.5 and 2.2 respectively)
The enzyme serine hydroxymethy ltransferase (SHMT) catalyses the conversion of serine into glycine. The fo llowing table gives the initial rates, vo, for the SHMT-catalysed reaction of the substrate serine at var ious concentratio ns of serine, lSI.[S]/(mmol dm-3) 10 20 30 40vo(μmol dm-3 s-1) 1.63 2.94 4.10 4.95Use the data to determine the values of the MichaelisMenten constant, the maximum velocity of the reaction, and the maximum turnover number of the enzyme.
The Mechanism of Action of Cyclophosphamide and its toxicity reference :http://dx.doi.org/10.3390/scipharm88040042 (reseach paper DOI plz answer in detail do not give short answer )
Heterozygotes for erythropoietic protoporphyria show only 20 to 30% residual ferrochelatase activity rather than the 50% that is normally expected for an autosomal dominant inherited disease. Provide a plausible explanation for this observation.
A notable increase of the activities of CPK МВ (creatine phosphokinase? MB isoform) and LDH-1 were revealed at examination of patient’s blood. What is the most likely pathology?
Which of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. Toconazole
A newborn girl appeared normal at birth, but within 24 hours she developed lethargy,hypothermia, and apnea. The attending physician suspects a metabolic disorder andorders a panel of labs.A full blood work up was ordered for this female and the data is presented below.The initial blood ammonia level was elevated at 314 ug/dl (normal range = 17–80) andrapidly rose to 600 ug/dl.Discuss the normal mechanisms of ammonia transfer in the body that should beoccurring, including glutamate dehydrogenase, glutaminase and glutamine synthetase.Be sure to discuss the role of transamination. How is nitrogen transport connected to gluconeogenesis in the fasted state? Further analysis shows urine orotic acid levels were markedly elevated at 473 umol/Lcreatinine (nl = 0– 3). The plasma citrulline level was normal at 10 uM/L (nl = 12–55).In thisindividual, where orotic acid levels are elevated, what urea cycle enzyme is mostlikely deficient and what urea cycle enzyme isleast likely to be impaired? (Be…
A 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.