Concept explainers
Antibiotics such as tetracycline, streptomycin, and bacitracin are small organic molecules that are synthesized by particular species of bacteria. Microbiologists have hypothesized that the reason why certain bacteria make antibiotics is to kill other species that occupy the same environment. Bacteria that produce an antibiotic may be able to kill competing species. This provides more
A. What form of genetic transfer (i.e., conjugation, transduction, or transformation) is the most likely mechanism of interspecies gene transfer?
B. Because S. aureofaciens is a nonpathogenic soil bacterium and E. coli is an enteric bacterium, do you think the genetic transfer was direct, or do you think it may have occurred in multiple steps (i.e., from S. aureofaciens to other bacterial species and then to E. coli)?
C. How could the widespread use of antibiotics to treat diseases have contributed to the proliferation of many bacterial species that are resistant to antibiotics?
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Genetics: Analysis and Principles
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- A4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues. Question: If the infant was given antibiotics, how might this have contributed to the production of resistant bacteria?arrow_forwardA4-month-old infant had been running a moderate fever for36 hours, and a nervous mother made a call to her pediatrician.Examination and tests revealed no outward signs of infectionor cause of the fever. The anxious mother wanted a prescription for antibiotics, but the pediatrician recommended watching the infant for two days before making a decision. He explained that decades of rampant use of antibiotics in medicine and agriculture has caused a global surge in antibiotic-resistant bacteria, drastically reducing the effectiveness of antibiotic therapy for infections. He pointed out that bacteria can exchange antibiotic resistance traits and that many pathogenic strains are now resistant to several antibiotics. The mother wasnot placated by these explanations and insisted that her baby receive antibiotics immediately. This situation raises several issues. Question:If you were an anxious parent of the patient, would it change your mind if you learned that a woman died in 2016 from a…arrow_forwardA mutation that provides a bacterium with resistance to an antibiotic will be beneficial in all environments. True Falsearrow_forward
- The discovery and mass-production of antibiotics has triggered a revolution in medicine, decreasing hospitalization times, shortening the course of diseases, and ultimately increasing peoples' lifespans. However, soon after the first major antibiotic, penicillin, was put into widespread use around 1940, people soon found that some bacteria were tougher to kill, which were the first signs of antibiotic resistance in bacteria. Over the years bacteria have been able to develop resistance against many different types of antibiotics, and some bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) is resistant to almost every antibiotic in use today. Antibiotic resistance has become so severe that in 2014 the World Health Organization published a report that speculated of a "post-antibiotic era" where antibiotics were no longer a main method of disease treatment. In this week's forum, please read summary of the World Health Organization's report (linked here and in the…arrow_forwardWhich of the statements is TRUE about conjugation? a) Plasmid DNA is transferred from a donor (F+) cell b) It may only be performed by competent cells c) DNA is always integrated into recipient chromosome d) It may be specialized or generalizedarrow_forwardYou are studying a type of bacteria isolated from the acidic water runoff of a mining operation. You subject two batches of the same bacteria type to different environmental growth conditions. One batch is grown at pH 2, while the other is grown at pH 7. All other environmental parameters are kept identical between the two batches. You then collect their proteins and run a Western blot using an antibody that binds to a proton efflux pump protein (which actively expends energy to pump protons out of a cell). How would you characterize the information obtained in this experiment? What does it tell you, and why is that potentially valuable information?arrow_forward
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