Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 5.4, Problem 3COMQ
Some human diseases are caused by mutations in mitochondrial genes. Which of the following statements is false?
a. Human mitochondrial diseases follow a maternal inheritance pattern.
b. Mutations associated with mitochondrial diseases often affect cells with a high demand for ATP.
c. The symptoms associated with mitochondrial diseases tend to improve with age.
d. Heteroplasmy plays a key role in the severity of mitochondrial disease symptoms.
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Chapter 5 Solutions
Genetics: Analysis and Principles
Ch. 5.1 - A female snail that coils to the left has...Ch. 5.1 - 2. What is the molecular explanation for maternal...Ch. 5.2 - 1. In fruit flies, dosage compensation is achieved...Ch. 5.2 - 2. According to the Lyon hypothesis,
a. one of...Ch. 5.2 - Prob. 3COMQCh. 5.3 - 1. In mice, the copy of the Igf2 gene that is...Ch. 5.3 - 2. A female mouse that is is crossed to a male...Ch. 5.3 - Prob. 3COMQCh. 5.3 - Prob. 4COMQCh. 5.4 - 1. Extranuclear inheritance occurs due to
a....
Ch. 5.4 - 2. A cross is made between a green four-o’clock...Ch. 5.4 - 3. Some human diseases are caused by mutations in...Ch. 5.4 - 4. Chloroplasts and mitochondria evolved from an...Ch. 5 - Define the term epigenetic inheritance, and...Ch. 5 - 2. Describe the inheritance pattern of maternal...Ch. 5 - A maternal effect gene exists in a dominant N...Ch. 5 - 4. A Drosophila embryo dies during early...Ch. 5 - 5. For Mendelian inheritance, the nuclear genotype...Ch. 5 - Suppose a maternal effect gene exists as a...Ch. 5 - Suppose that a gene affects the anterior...Ch. 5 - Explain why maternal effect genes exert their...Ch. 5 - As described in Chapter 22, researchers have been...Ch. 5 - 10. With regard to the numbers of sex chromosomes,...Ch. 5 - 11. What is a Barr body? How is its structure...Ch. 5 - Among different species, describe three distinct...Ch. 5 - 13. Describe when X-chromosome inactivation occurs...Ch. 5 - 14. Describe the molecular process of X-chromosome...Ch. 5 - Prob. 15CONQCh. 5 - 16. How many Barr bodies would you expect to find...Ch. 5 - 17. Certain forms of human color blindness are...Ch. 5 - A black female cat (XBXB) and an orange male cat...Ch. 5 - Prob. 19CONQCh. 5 - When does the erasure and reestablishment phase of...Ch. 5 - In what types of cells would you expect de novo...Ch. 5 - 22. On rare occasions, people are born with a...Ch. 5 - Genes that cause Prader-Willi syndrome and...Ch. 5 - Prob. 24CONQCh. 5 - What is extranuclear inheritance? Describe three...Ch. 5 - Prob. 26CONQCh. 5 - Among different species, does extranuclear...Ch. 5 - Extranuclear inheritance often correlates with...Ch. 5 - Prob. 29CONQCh. 5 - Prob. 30CONQCh. 5 - Which of the following traits or diseases is (are)...Ch. 5 - Prob. 32CONQCh. 5 - 33. Describe how a biparental pattern of...Ch. 5 - Figure 5.1 describes an example of a maternal...Ch. 5 - 2. Discuss the types of experimental observations...Ch. 5 - Prob. 3EQCh. 5 - As a hypothetical example, a trait in mice results...Ch. 5 - You have a female snail that coils to the right,...Ch. 5 - Prob. 6EQCh. 5 - 7. Figure 5.6 describes the results of...Ch. 5 - Prob. 8EQCh. 5 - In the experiment of Figure 5.6, why does a clone...Ch. 5 - Prob. 10EQCh. 5 - 11. A variegated trait in plants is analyzed using...Ch. 5 - 1. Recessive maternal effect genes are identified...Ch. 5 - Prob. 2QSDC
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- 1) Which of the following contains all of the information required to target a precursor protein from the cytosol to the mitochondrial matrix? a. N-terminal uptake-targeting sequence b. C-terminal uptake-targeting sequence c. post-translational organelle d. translocon e. None of the above 2) In the absence of targeting information, what is the default location of proteins synthesized on cytosolic ribosomes? a. Golgi apparatus b. ER lumun c. Cytosol d. Cell plasma membrane e. ER membranearrow_forwardLeber’s Hereditary Optic Neuropathy (LHON) is a disease that involves degeneration of neural cells in the retina and results in loss of central vision. The disease is caused by mutations in any one of three genes in the mitochondrial genome that encode proteins involved in oxidative phosphorylation. In a genetic counseling clinic, a woman and her husband seek advice on the potential that any of their children would be afflicted with LHON. The husband's mother and father, both exhibit symptoms of the disease, but the woman does not. What is a reasonable advising statement to make? a. The couple should be advised that all of their children are likely to display symptoms of LHON. b. There is not enough information to advise this couple. c. The couple should be advised that none of their children will be affected. d. The couple should be advised that all their male children will display symptoms of LHON, but female children will be unaffected. e. The couple should be…arrow_forwardLeber’s Hereditary Optic Neuropathy (LHON) is a disease that involves degeneration of neural cells in the retina and results in loss of central vision. The disease is caused by mutations in any one of three genes in the mitochondrial genome that encode proteins involved in oxidative phosphorylation. In a genetic counseling clinic, a woman and her husband seek advice on the potential that any of their children would be afflicted with LHON. The husband's mother and father, both exhibit symptoms of the disease, but the woman does not. What is a reasonable advising statement to make?arrow_forward
- Leber's Hereditary Optic Neuropathy (LHON) is a disease that involves degeneration of neural cells in the retina and results in loss of central vision. The disease is caused by mutations in any one of three genes in the mitochondrial genome that encode proteins involved in oxidative phosphorylation. In a genetic counseling clinic, a woman and her husband seek advice on the potential that any of their children would be afflicted with LHON. The husband's mother and father, both exhibit symptoms of the disease, but the woman does not. What is a reasonable advising statement to make? There is not enough information to advise this couple. a. The couple should be advised that all of their children are likely to display symptoms of LHON. b. The couple should be advised that all their female children will display symptoms of LHON, but male children will be unaffected. C. The couple should be advised that all their male children will display symptoms of LHON, but female children will be…arrow_forwardThe Perrier1 mutation of Chlamydomonas results in cells unable to generate ATP by oxidative phosphorylation. Which of the following is a possible genetic basis for this mutation? A. Defect to a nuclear gene that codes for a mitochondrial protein. B. Defect to a nuclear gene that codes for a cytosolic protein. C. Defect to a mitochondrial gene that codes for nuclear protein. D. Defect to a mitochondrial gene that gets translated on cytosolic ribosomes.arrow_forwardIs each of these statements true of chloroplast or mitochondrial genomes, both, or neither? a.contain tRNA genesarrow_forward
- Mitochondria contain their own genetic material. Mitochondrialmutations are inherited from mother to child, without anycontribution from the father. Why?arrow_forward1) Discuss the roles of epidermal growth factor receptor (EGFR) in normal cell signalling transduction and in cancer development. 2) Describe uniparental inheritance of mitochondrial DNA and discuss its importance in human disease and potential treatment strategiesarrow_forwardExplain why we expect mitochondria to have more mutations that are harmful to males than to females.arrow_forward
- Explain the action of the mitochondrial uncoupling proteinarrow_forwardIs each of these statements true of chloroplast or mitochondrial genomes, both, or neither?a. contain tRNA genesb. encode proteins that participate in electron transport pathwaysc. all genes necessary for function of the organelleare presentd. vary greatly in size from organism to organismarrow_forwardWhich of the following statements is true about the effects of mutations in somatic cells and gametes? A. Only mutations in gametes can affect future generations. B. Only mutations in somatic cells can affect future generations. C. Neither mutations in somatic cells or gametes can affect future generations. D. Mutations in both somatic cells and gametes can affect future generations.arrow_forward
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