Interpretation:
The reason why denaturation of proteins makes them better substrates for proteolysis should be determined.
Concept Introduction:
Proteolysis can be defined as the breakdown of peptides or proteins into amino acids by the action of enzymes. It is classically catalyzed by the proteases that are cellular enzymes. It occurs by intra-molecular digestion. Denaturation of proteins means the degradation of proteins to a simpler level.
Answer to Problem 1P
When the proteins become denatured, they are more accessible by the proteolytic enzymes as substrates for the proteolysis process than are natural proteins.
Explanation of Solution
A protein has a 3-dimensional structure that is not accessible to the proteolytic enzymes. It happens because the proteolytic enzymes cannot act on the peptide bond when the proteins become denatured. Denatured proteins are therefore more accessible as substrates for the proteolysis process than are the natural proteins.
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Chapter 23 Solutions
Biochemistry
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- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning