Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 23, Problem 30P
Interpretation Introduction
Interpretation:
The way by which Argininosuccinic aciduria can be treated should be determined.
Concept introduction:
The urea cycle is a series of biochemical reactions which involve the formation of urea (NH2)2CO from the ammonia (NH3). It is also known as the ornithine cycle. It helps in the excretion of toxic ammonia by converting into urea. This cycle takes place in ureotelic organisms. Argininosuccinase or argininosuccinate lyase or ASL is an enzyme which catalyzes the reversible breakdown of argininosuccinate and produces arginine and fumarate.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
+
edu.au/courses/26618/quizzes/67364/take
The image below shows the urea cycle. Based on the information in the image, which
of the following is the most effective way of reducing the production of urea?
CNH,
Fumarate Arginine H₂O
Arginase
NH3+
C=N
Arginino-
succinate
AMP
+
PP₁
NH₂
Arginino-
succinase
UREA CYCLE
Urea
ATP
Argininosuccinate
synthetase
Ornithine
H₂N
H₂N
2
Citrulline
Rate-
limiting
Ornithine
1.
Carbamoyl
phosphate
synthase 1
N-acetyl
glutamate
H+ADP P₁
NH3
HCO3
ATP
Carbamoyl
Phosph.
NH₂C-PO4
Ornithine
2.
Citrulline
formation P
Citrulline C-NH₂
transcarbamoylase
Aspartate
NH₂
CYTOSOL
MITOCHONDRIAL MATRIX
https://canvas.uts.edu.au/assessment questions/356957/files/1562677/download?
verifier=gRMPoy7VCgDrvn6QNfkZxDSsbLUwP1gRxFB3dLPj
Explain why the symptoms of a partial defi ciency in a urea cycle enzyme can be attenuated by a low-protein diet.
Amino acid degradation and biosynthesis are related metabolic processes, but they are not identical. Indicate two ways in which they
are similar and one in which they are different. Be as specific as you can.
Chapter 23 Solutions
Biochemistry
Ch. 23 - Prob. 1PCh. 23 - Prob. 2PCh. 23 - Prob. 3PCh. 23 - Prob. 4PCh. 23 - Prob. 5PCh. 23 - Prob. 6PCh. 23 - Prob. 7PCh. 23 - Prob. 8PCh. 23 - Prob. 9PCh. 23 - Prob. 10P
Ch. 23 - Prob. 11PCh. 23 - Prob. 12PCh. 23 - Prob. 13PCh. 23 - Prob. 14PCh. 23 - Prob. 15PCh. 23 - Prob. 16PCh. 23 - Prob. 17PCh. 23 - Prob. 18PCh. 23 - Prob. 19PCh. 23 - Prob. 20PCh. 23 - Prob. 21PCh. 23 - Prob. 22PCh. 23 - Prob. 23PCh. 23 - Prob. 24PCh. 23 - Prob. 25PCh. 23 - Prob. 26PCh. 23 - Prob. 27PCh. 23 - Prob. 28PCh. 23 - Prob. 29PCh. 23 - Prob. 30PCh. 23 - Prob. 31PCh. 23 - Prob. 32PCh. 23 - Prob. 33PCh. 23 - Prob. 34PCh. 23 - Prob. 35PCh. 23 - Prob. 36PCh. 23 - Prob. 37PCh. 23 - Prob. 38PCh. 23 - Prob. 39PCh. 23 - Prob. 40PCh. 23 - Prob. 41PCh. 23 - Prob. 42PCh. 23 - Prob. 43PCh. 23 - Prob. 44PCh. 23 - Prob. 45PCh. 23 - Prob. 46PCh. 23 - Prob. 47PCh. 23 - Prob. 48PCh. 23 - Prob. 49P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- hyperammonemia in patients is compounded by the reality of the normal regulatory controls in the urea cycle. Explain how increased GDH oxidative deamination activity will inhibit the urea cycle.arrow_forwardBy definition, essential amino acids are not synthesized by an organism. Arginine is classified as an essential amino acid in infants, even though it is part of the urea cycle. Explain.arrow_forwardWhat is the possible connection between the Urea cycle and other metabolic pathways? Can intermediates of the urea cycle can serve as precursors for amino acid, carbohydrate, fatty acid, and/or nucleotide metabolism (anabolism/catabolism). Give examples. . avoid copyrighting and plagiarism.arrow_forward
- e/0/S Anemic patient diagnosed clinically through his symptoms which are: weakness, fatigue, shortness of breath, and dizziness. The lab. results of his hemoglobin level was less than 8 g/dl. On the examination of his Red blood cells isolated from the patient showed abnormally low level of lactic acid production. A deficiency of which one of the following enzymes would be the most likely cause of this patient's anemia? * Pyruvate kinase Hexokinase All of the above Phosphofructokinase Phosphoglucose isomerase Lactate dehydrogenasearrow_forwardexplain the phenylketonuria disease mechanismarrow_forwardConsider this mechanism of enzyme action: Urease can catalyze the hydrolysis of Urea, H,N – C – NH, II but not H H the hydrolysis of diethyl urea N -C - C;H5 C2H5 Explain this action.arrow_forward
- Argininosuccinic aciduria is a condition that results when the urea-cycle enzyme argininosuccinase is deficient. Argininosuccinate is present in the blood and urine. Suggest how this condition might be treated while still removing nitrogen from the body.arrow_forwardProduction of the enzymes that catalyze the reactions of the urea cycle can increase or decrease according to the metabolic needs of the organism. High levels of these enzymes are associated with high-protein diets as well as starvation. Explain this apparent paradox.arrow_forwardSome amino acids are both glucogenic and ketogenic. Explain the difference between the two types and why some amino acids can be both.arrow_forward
- Nonalcoholic fatty liver disease is thought to be exacerbated by a diet heavy in sugar. Explain?arrow_forwardExplain the process of amino acid oxidation (go through it step by step in a chronological order)arrow_forwardExplain why glycated haemoglobin (HbA1C) is a suitable index for long term hyperglycaemia.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Macromolecules | Classes and Functions; Author: 2 Minute Classroom;https://www.youtube.com/watch?v=V5hhrDFo8Vk;License: Standard youtube license