Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 16, Problem 5P

The figure at the beginning of this chapter shows the binding of both a Lac repressor tetramer and a CRP-cAMP

complex to the regulatory region of the lac operon.

a. What is the key feature of a regulatory protein such as the Lac repressor or CRP that allows it to regulate
specifically the genes or operons it is supposed to control?
b. On the figure, show the positions of the following components: (i) A Lac repressor monomer; (ii) a Lac
repressor dimer; (iii) all four DNA binding domains of the Lac repressor tetramer; (iv) a single helix-turn helix motif; (v) the o part and either the o or o parts of the lac operator (assume the operon would be
transcribed from right to left on the figure); (vi) the multimerization domains of the four Lac repressor
monomers; (vii) an inducer-interacting domain; (viii) the CRP-cAMP complex; and (ix) a DNA loop.
c. What is the physical basis for the formation of the DNA loop shown in the figure?
d. On the figure, show the position of two axes of symmetry in the sequence of DNA. How do you know, only on the basis of the figure and without prior information about the precise DNA sequence, that these two axes of symmetry are likely to be present in the DNA and that the sequences around these axes are rotationally symmetrical?
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The L-arabinose operon, also called ara, is an operon required to break down the sugar L-arabinose in E. coli. This operon contains 3 structural genes in the following order, araB, araA, araD and expression is controlled by the product of a repressor called araC and the CAP protein which is regulated by cAMP in the same way as it is for the lactose operon.   Now Draw a schematic of what this operon might look like when glucose levels are low and arabinose levels are high. Include the relevant proteins and their effector molecules, the promoter, operator, and structural genes. Note if the operon is being transcribed or not.
The L-arabinose operon, also called ara, is an operon required to break down the sugar L-arabinose in E. coli. This operon contains 3 structural genes in the following order, araB, araA, araD and expression is controlled by the product of a repressor called araC and the CAP protein which is regulated by cAMP in the same way as it is for the lactose operon. From the available information here, draw a schematic of what this operon might look like when glucose levels are low and arabinose levels are high. Include the relevant proteins and their effector molecules, the promoter, operator, and structural genes. Note if the operon is being transcribed or not.
The lactose operon in E. coli comprises two structural genes and three regulatory components.a.State the name of each structural gene and describe its function: b.) State the name of each regulatory component and describe its function

Chapter 16 Solutions

Genetics: From Genes to Genomes

Ch. 16 - Mutants were isolated in which the constitutive...Ch. 16 - Suppose you have six strains of E. coli. One is...Ch. 16 - The previous problem raises some interesting...Ch. 16 - For each of the E. coli strains containing the lac...Ch. 16 - For each of the following growth conditions, what...Ch. 16 - For each of the following mutant E. coli strains,...Ch. 16 - Maltose utilization in E. coli requires the...Ch. 16 - Seven E. coli mutants were isolated. The activity...Ch. 16 - Cells containing missense mutations in the crp...Ch. 16 - Six strains of E.coli mutants 16 that had one of...Ch. 16 - a. The original constitutive operator mutations in...Ch. 16 - In an effort to determine the location of an...Ch. 16 - Prob. 23PCh. 16 - The footprinting experiment described in Fig....Ch. 16 - Why is the trp attenuation mechanism unique to...Ch. 16 - a. How many ribosomes are required at a minimum...Ch. 16 - The following is a sequence of the leader region...Ch. 16 - For each of the E. coli strains that follow,...Ch. 16 - Prob. 29PCh. 16 - For each element in the list that follows,...Ch. 16 - Among the structurally simplest riboswitches are...Ch. 16 - Great variation exists in the mechanisms by which...Ch. 16 - Many genes whose expression is turned on by DNA...Ch. 16 - In 2005, Frederick Blattner and his colleagues...Ch. 16 - The E.coli MalT protein is a positive regulator of...Ch. 16 - Prob. 36PCh. 16 - Prob. 37PCh. 16 - Prob. 38PCh. 16 - Prob. 39PCh. 16 - Prob. 40PCh. 16 - Prob. 41PCh. 16 - The researchers who investigated bioluminescence...Ch. 16 - Prob. 43PCh. 16 - Quorum sensing controls the expression of...Ch. 16 - Scientists are currently screening a chemical...
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