Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 15, Problem 22PDQ
Summary Introduction
To determine: The ways in which TE insertions might positively contribute to evolution.
Introduction: Transposable elements (TE) are the sequence of DNA that is capable of changing their position in the genome. TE insertions are usually referred to as junk DNA segments because no function of these elements has been identified yet.
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You are collaborating with a cool new local brewery on an experiment with one of their strains Saccharomyces cerevisiae, brewer’s yeast. You decide to apply what you learned in Evolution to create a mutation accumulation (MA) line to see if the patterns of mutation in their strain of S. cerevisiae follow patterns seen in other species. Which of the following best describes an actual result you observe form studying the mutation accumulation (MA) lines you created?
a.
Beneficial mutations occur far less frequently than deleterious mutations do.
b.
The neutral mutations had a greater effect on fitness compared to other mutation types.
c.
Most of the mutations that occur are the result of large chromosomal rearrangements.
d.
Of all possible mutation types, deleterious mutations are the most common mutation.
Do the data in the graph indicate that the mutation rates per base-pair in some taxa, such as mammals, are not at the lowest possible rate? Is this evidence that a certain level of mutations is an adaptation? Why or why not?
For each of the following examples, discuss whether the observed result is due to neutral mutations or mutations that have been acted on by natural selection, or both:
A. When comparing sequences of homologous genes, differences in the coding sequence are most common at the wobble base (i.e., the third base in each codon).
B. For a protein-encoding gene, the regions that encode portions of the polypeptide that are vital for structure and function are less likely to display mutations than other regions of the gene.
C. When comparing the sequences of homologous genes, introns usually have more sequence differences than exons.
Chapter 15 Solutions
Concepts of Genetics (12th Edition)
Ch. 15 - If a point mutation occurs within a human egg cell...Ch. 15 - One of the most famous cases of an X-linked...Ch. 15 - The cancer drug melphalan is an alkylating agent...Ch. 15 - Geneticists often use the alkylating agent...Ch. 15 - Six months pregnant, an expectant mother had a...Ch. 15 - Six months pregnant, an expectant mother had a...Ch. 15 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 15 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 15 - What is a spontaneous mutation, and why are...Ch. 15 - Prob. 4PDQ
Ch. 15 - Prob. 5PDQCh. 15 - Why is a random mutation more likely to be...Ch. 15 - Most mutations in a diploid organism are...Ch. 15 - What is the difference between a silent mutation...Ch. 15 - Describe a tautomeric shift and how it may lead to...Ch. 15 - Contrast and compare the mutagenic effects of...Ch. 15 - Why are frameshift mutations likely to be more...Ch. 15 - Why are X rays more potent mutagens than UV...Ch. 15 - DNA damage brought on by a variety of natural and...Ch. 15 - Contrast the various types of DNA repair...Ch. 15 - Mammography is an accurate screening technique for...Ch. 15 - A significant number of mutations in the HBB gene...Ch. 15 - Describe how the Ames test screens for potential...Ch. 15 - Prob. 18PDQCh. 15 - Compare DNA transposons and retrotransposons. What...Ch. 15 - Prob. 20PDQCh. 15 - In maize, a Ds or Ac transposon can alter the...Ch. 15 - Prob. 22PDQCh. 15 - In a bacterial culture in which all cells are...Ch. 15 - Presented here are hypothetical findings from...Ch. 15 - Prob. 25ESPCh. 15 - Prob. 26ESPCh. 15 - What evidence indicates that mutations in human...Ch. 15 - Among Betazoids in the world of Star Trek, the...Ch. 15 - Skin cancer carries a lifetime risk nearly equal...Ch. 15 - It has been noted that most transposons in humans...Ch. 15 - Mutations in the IL2RG gene cause approximately 30...
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- What is the difference between a neutral and an adaptive evolutionary process? Describe two or more examples of each. At the molecular level, explain how mutations can be neutral or adaptive.arrow_forwardIn what sense does the universality of the genetic code support the theory of evolution?arrow_forwardAs discussed, the overall rate of mutations in humans is estimated to be about 1 × 10−8 mutations per base pair per generation. How many new mutations would you expect each person to carry, on average, based on this mutation rate? Other studies have estimated that each person carries about 100 new loss-of-function mutations. How does this number compare with your estimate of the number of mutations based on the mutation rate? What might account for any differences?arrow_forward
- Which of the proteins is changing at the slowest rate and is most conserved? OA OB Oc O cannot be determined based on this grapharrow_forwardWhat is a gene? Why are regulatory genes important to the evolutionary process? What is a mutation as defined in this course and readings. Are the end results of a mutation always "good" or always "bad"? Or is a mutation perhaps neither always good or always bad and could be "neutral or no effect" or "adaptive" in some situations? Does it depend on the gene, amino acid, protein, and case-by-case scenario? What genetic evidence suggests that humans are a part of a biological continuum with all life forms. Does the number of genes in a biological organism correlate, predict, or denote the complexity of the organism? Does the number of chromosomes in a biological organism correlate, predict, or denote the complexity of the organism?arrow_forwardIn your own words, define the terms “orthologous” and “paralogous” genes. Then briefly suggest by what mechanism, during evolution, each of these is most likely to have arisen.arrow_forward
- In your own words, define the terms “orthologous” and “paralogous” genes. Then, briefly suggest by what mechanism, during evolution, each of these homologous gene types is most likely to have arisen.arrow_forwardRecent studies reveal that certain areas of the DNA are less prone to DNA mutations and that mutations may not be random after all. In a study on Arabidopsis thaliana, important genes that are involved in cell growth and expression have been observed to have low mutation rates. What is a possible implication of this observation in evolution?arrow_forwardOur DNA is subject to mutations on a daily basis. Why do most mutations that occur in the genome of organisms escape detection and not elicit a deleterious effect? Why does the child of someone with cancer not necessarily develop cancer? Is it reasonable to state that mutations are essential to the evolutionary process?arrow_forward
- Write a paragraph describing the evolutionary forces driving changes in the human genome. You can include evolutionary forces such as random genetic drift, mutation, migration, and natural selection. These forces would have long-term and short-term effects on coding and non-coding DNA, the abundance of transposable elements, and the birth and death of genes. You can focus on a subset of the human population, or the entire species.arrow_forwardAn analysis of the human genome revealed that some regions of DNA that are highly conserved across species do not code for proteins. Propose an explanation for why these noncoding regions are conserved and what this could mean in terms of evolution.arrow_forwardAssume that the molecular clock for the alcohol dehydrogenase (Adh) gene in Drosophila ticks at a rate of 5 X 10-⁹ substitutions per bp per year. On a volcanic island you find two species of Drosophila, descended from one species that colonized the island sometime after it first rose out of the ocean. You sequence the Adh genes of the two species and find they show 5 synonymous substitutions in 1,000 bp. 2A. What is the rate of divergence between these 2 species of Drosophila? (Hint: Recall that substitutions are happening in both species.) 2B. How long ago did the two species diverge? 2C. How old is the island? Hint: you cannot give an exact age.arrow_forward
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