Recent studies reveal that certain areas of the DNA are less prone to DNA mutations and that mutations may not be random after all. In a study on Arabidopsis thaliana, important genes that are involved in cell growth and expression have been observed to have low mutation rates. What is a possible implication of this observation in evolution?
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- You are collaborating with a cool new local brewery on an experiment with one of their strains Saccharomyces cerevisiae, brewer’s yeast. You decide to apply what you learned in Evolution to create a mutation accumulation (MA) line to see if the patterns of mutation in their strain of S. cerevisiae follow patterns seen in other species. Which of the following best describes an actual result you observe form studying the mutation accumulation (MA) lines you created? a. Beneficial mutations occur far less frequently than deleterious mutations do. b. The neutral mutations had a greater effect on fitness compared to other mutation types. c. Most of the mutations that occur are the result of large chromosomal rearrangements. d. Of all possible mutation types, deleterious mutations are the most common mutation.What is the difference between a neutral and an adaptive evolutionary process? Describe two or more examples of each. At the molecular level, explain how mutations can be neutral or adaptive.For each of the following examples, discuss whether the observed result is due to neutral mutations or mutations that have been acted on by natural selection, or both: A. When comparing sequences of homologous genes, differences in the coding sequence are most common at the wobble base (i.e., the third base in each codon). B. For a protein-encoding gene, the regions that encode portions of the polypeptide that are vital for structure and function are less likely to display mutations than other regions of the gene. C. When comparing the sequences of homologous genes, introns usually have more sequence differences than exons.
- Genes control thousands of different traits in plants. These genes can be selected for during natural selection (which drives evolution) and artificial selection (which drives domestication of dogs, crops, etc). During the domestication of modern tomato, describe the traits that were and were not selected. In your own words, describe in 2-3 sentences why domesticated tomatoes bought at a grocery store are lackluster compared to heirlooms or wild tomatoes. What are a few genetic and non-genetic traits that control tomato flavor and taste?What is a gene? Why are regulatory genes important to the evolutionary process? What is a mutation as defined in this course and readings. Are the end results of a mutation always "good" or always "bad"? Or is a mutation perhaps neither always good or always bad and could be "neutral or no effect" or "adaptive" in some situations? Does it depend on the gene, amino acid, protein, and case-by-case scenario? What genetic evidence suggests that humans are a part of a biological continuum with all life forms. Does the number of genes in a biological organism correlate, predict, or denote the complexity of the organism? Does the number of chromosomes in a biological organism correlate, predict, or denote the complexity of the organism?A common misconception of evolution is that it should naturally eliminate "harmful" alleles/mutations if they do not assist survival or reproduction. Explain why this is inaccurate and how these "harmful" mendelian alleles persist within the human genome. In your response, give an example of a mendelian allele that causes a "harmful" genetic disease that does not appear to have a beneficial component
- The platypus is one of a very small number of mammals that are venomous. Researchers compared the substances in the platypus venom to that of venomous reptiles. They found that the venom in platypus was derived from a protein called defensin, while that in many reptiles was based on a protein called crotamine. The protein structure of these molecules is remarkably similar, though they are controlled by unrelated genes in each taxa. Both molecules originated as non-toxic antimicrobial compounds. Part A: Venom in both platypus and reptiles is an example of: A. Homologous traits B. Analogous traits C. Adaptive radiation D. Genetic drift Part B: A trait matrix for the amniotes is below. Using the trait matrix, match the taxa to the letters at the branch tips. (see attached image) Using the image, match the taxa to the letters at the branch tips 1. Chicken 2. Kangaroo 3. Viviparity 4. Placenta Part C: In which location(s) did each trait evolve on the phylogeny? If more than one location…Which of the following best explains the number of similarities between the amino acid sequences of the Drosophila Hedgehog protein and the Chicken Indian Hedgehog protein? O A. The Drosophila hedgehog gene evolved from hedgehogs, which are distantly related to birds. O B. Both genes evolved from a gene present in the last common ancestor of Drosphila and chickens, and the number of differences reflects the amount of time that has elapsed during the evolution of these two lineages. a During the evolution of Drosophila and chickens, a hedgehog like gene arose independently in each lineage, then the gene that arose in chickens diversified. A These genes are unrelated, and the fact that they are similar is only because the proteins need to have similar biochemical properties. They are unrelated because chickens don't have segments and Drosophila larvae don't have limb buds.In addition to physical traits, gene sequences can be used when comparing related species. Instead of looking for the presence or absence of a specific gene, you would look at the percent similarity between the same gene in two or more species. Therefore, it is important to select a gene that contains a similar DNA gene sequence in each of the species being compared. Certain genes are involved in processes that are required for basic cellular function. As these processes are critical to cell function, the genes that regulate them are highly conserved, meaning that they have remained essentially unchanged over time. Glycolysis is one such process that is critical for cellular metabolism. Glycolysis involves converting glucose into pyruvate in order to generate ATP, the energy currency of the cell. Because glycolysis is an essential process for all species, the genes involved are therefore highly conserved. You will be looking at similarities among different taxa of the highly conserved…
- Gregor Mendel never saw a gene, yet he concluded that some inherited factors were responsible for the patterns of inheritance he observed in peas. Similarly, maps of Drosophila chromosomes (and the very idea that genes are carried on chromosomes) were conceived by observing the patterns of inheritance of linked genes, not by observing the genes directly. Is it legitimate for biologists to claim the existence of objects and processes they cannot actually see? How do scientists know whether an explanation is correct?Many animals have the p53 gene that makes a protein that regulates the cell cycle and helps prevent the formation of cancer cells. The table below shows the percentage of p53 gene sequences that the 4 species have when compared to humans. Species Percentage of p53 Gene Sequence Similar to Human Human 100 Horse 60.7 Fruit Fly 15.5 Rat 76.8 Pig 81.3 Which organism in the table is most closely related to humans based on this data? pig horse fruit fly rat 0 0 0 0Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has severe effects in males but no effect in females will not be eliminated from a population by natural selection because only females pass on mtDNA (S. A. Frank and L. D. Hurst. 1996. Nature 383:224). Using this argument, explain why males with Leber hereditary optic neuropathy are more severely affected than females.