Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 12.4, Problem 21AYP
Summary Introduction
Toenlist:
Five cellular or structural mechanisms that microbes use to resist antimicrobials.
Concept introduction:
When microbes can tolerate an amount of antimicrobial drug which would generally be inhibitory, it is called drug resistance. Microbes have characteristic of drug resistance because they have incredible genetic versatility and adaptability of bacterial population.
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Students have asked these similar questions
The type of antimicrobial drug that would be most likely to have toxic effects in
humans based on the premise of selective toxicity when treating microbial infection
would be a drug that
O 1) inhibits the synthesis of the cell wall
O 2) inhibits metabolic pathways
O 3) disrupts the cytoplasmic membrane
4) inhibits protein synthesis
5) All of the above have equal potential to be toxic
Important characteristics of antimicrobial drugs include:
a) readily delivered to the site of infection
b) high toxicity against microbial cells
c) do not cause serious side effects in humans
d) remains active in body tissues and fluids
e) all of the above
Differentiate between the following and provide one example broad- and narrow-spectrum antimicrobials
Chapter 12 Solutions
Microbiology: A Systems Approach
Ch. 12.1 - State the main goal of antimicrobial treatment.Ch. 12.1 - Identify sources of the most commonly used...Ch. 12.1 - Summarize two methods for testing antimicrobial...Ch. 12.1 - Prob. 4AYPCh. 12.2 - Prob. 5AYPCh. 12.2 - Describe the five major targets of antimicrobial...Ch. 12.2 - Identify which categories of drugs are most...Ch. 12.3 - Prob. 8AYPCh. 12.3 - Trace the development of penicillin...Ch. 12.3 - Prob. 10AYP
Ch. 12.3 - Prob. 11AYPCh. 12.3 - Prob. 12AYPCh. 12.3 - Prob. 13AYPCh. 12.3 - Identify the cellular target of quinolones, and...Ch. 12.3 - Prob. 15AYPCh. 12.3 - Prob. 16AYPCh. 12.3 - Prob. 17AYPCh. 12.3 - Prob. 18AYPCh. 12.3 - Describe two major modes of action of antiviral...Ch. 12.4 - Prob. 20AYPCh. 12.4 - Prob. 21AYPCh. 12.4 - Discuss at least three novel antimicrobial...Ch. 12.5 - Distinguish between drug toxicity and allergic...Ch. 12.5 - Prob. 24AYPCh. 12 - Prob. 1MCQCh. 12 - Prob. 2MCQCh. 12 - Prob. 3MCQCh. 12 - Microbial resistance to drugs is acquired through...Ch. 12 - Prob. 5MCQCh. 12 - Prob. 6MCQCh. 12 - Prob. 7MCQCh. 12 - Which of the following modes of action would be...Ch. 12 - Prob. 9MCQCh. 12 - Prob. 10MCQCh. 12 - Prob. 11TFCh. 12 - Prob. 12TFCh. 12 - Biofilms are difficult to treat and do not always...Ch. 12 - Prob. 14TFCh. 12 - Prob. 15TFCh. 12 - Construct a paragraph describing the...Ch. 12 - Prob. 2CTQCh. 12 - Antibiotic-resistance genes, as well as other...Ch. 12 - Prob. 4CTQCh. 12 - What is the significance of the bottom row in...Ch. 12 - Figure 12.5. Where could penicillinase affect each...Ch. 12 - From chapter 6, process figure 6.14a. Describe as...Ch. 12 - Prob. 1CM
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Broad-spectrum drugs target a wide variety of bacterial pathogens. Even when the broad-spectrum drug is capable of killing a target pathogen, it may not be the best treatment. Which statement best explains why a broad spectrum drug might be an undesirable treatment choice? Broad-spectrum antimicrobials are usually toxic to the host cells. Broad-spectrum antimicrobials only work if they are used shortly after the infection begins. Broad-spectrum antimicrobials may kill much of the normal microbiota. Broad-spectrum antimicrobials are not able to kill bacteria that are in their log phase of growth. Broad-spectrum antimicrobials may stimulate excess growth of the normal microbiota.arrow_forwardGive four main categories of antimicrobial products.arrow_forwardWhich of the following types of antimicrobial drugs make microbes more susceptible to osmotic pressure? 1) drugs that inhibit nucleic acid synthesis O 2) drugs that inhibit metabolic pathways 3) drugs that inhibit cell wall synthesis 4) drugs that block a pathogen's recognition of its host 5) drugs that inhibit protein synthesisarrow_forward
- describe four modes of action of antimicrobial agents, and give a specific example of how each worksarrow_forwardList 10 characteristics of an ideal antimicrobial drug.arrow_forwardIdentify two factors( in detail)that make biofilms more tolerant to antimicrobials including their mode of action.arrow_forward
- Could an organism that is susceptible to an antimicrobial agent in laboratory testing fail to respond to it when that drug is used to treat the patient? Explain.arrow_forwardDescribe four general mechanisms of antimicrobial resistance.arrow_forwardWhat are the 4 main targets of antimicrobials? Provide the rationale why each is a good target.arrow_forward
- What are the common neutralizing agents and methods used to inactivate the innate antimicrobial activity of a product?arrow_forwardName and describe three mechanisms of acquired antimicrobial resistance tools that microbes may use to thwart drug action.arrow_forwardDescribe four modes of action of antimicrobial agents, and provideexamples of how they work.arrow_forward
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