Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 12, Problem 6MCQ
Summary Introduction
Introduction:
Bacteriophage integrates their genome into the bacterial cell. The horizontal gene transfer (HGT) causes the transfer of DNA from one cell to another. In this case, the phage infects the bacterial cell by integrating their genome into the bacterial genome. The phage genome then induces certain changes into the host genome that results in transformation of the host to virulent strain.
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How is phage therapy different from antibiotic therapy?
usually kill many kinds of bacteria, including our
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specifically selected to kill one type of harmful (pathogenic)
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a. Plasmids: phage viruses
b. Phage viruses: antibiotics
Oc. Antibiotics: phage viruses
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Which of the following is not associated with gene therapy SCID patients
A) utilizes an enzyme to repair the patient’s nonfunctioning ADA gene
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Introduction: There’s quite a bit of interest around repurposing extant drugs to treat infections by targeting host pathways that pathogens rely on. Here are a few potential drugs:
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Question: Pick a drug and an infection that the drug is likely to be good at treating, or pick an infection and a drug that would most likely make the infection substantially worse. Which drug and pathogen did you pick? Do you think it’ll make it better or worse?
Chapter 12 Solutions
Microbiology: A Systems Approach
Ch. 12.1 - State the main goal of antimicrobial treatment.Ch. 12.1 - Identify sources of the most commonly used...Ch. 12.1 - Summarize two methods for testing antimicrobial...Ch. 12.1 - Prob. 4AYPCh. 12.2 - Prob. 5AYPCh. 12.2 - Describe the five major targets of antimicrobial...Ch. 12.2 - Identify which categories of drugs are most...Ch. 12.3 - Prob. 8AYPCh. 12.3 - Trace the development of penicillin...Ch. 12.3 - Prob. 10AYP
Ch. 12.3 - Prob. 11AYPCh. 12.3 - Prob. 12AYPCh. 12.3 - Prob. 13AYPCh. 12.3 - Identify the cellular target of quinolones, and...Ch. 12.3 - Prob. 15AYPCh. 12.3 - Prob. 16AYPCh. 12.3 - Prob. 17AYPCh. 12.3 - Prob. 18AYPCh. 12.3 - Describe two major modes of action of antiviral...Ch. 12.4 - Prob. 20AYPCh. 12.4 - Prob. 21AYPCh. 12.4 - Discuss at least three novel antimicrobial...Ch. 12.5 - Distinguish between drug toxicity and allergic...Ch. 12.5 - Prob. 24AYPCh. 12 - Prob. 1MCQCh. 12 - Prob. 2MCQCh. 12 - Prob. 3MCQCh. 12 - Microbial resistance to drugs is acquired through...Ch. 12 - Prob. 5MCQCh. 12 - Prob. 6MCQCh. 12 - Prob. 7MCQCh. 12 - Which of the following modes of action would be...Ch. 12 - Prob. 9MCQCh. 12 - Prob. 10MCQCh. 12 - Prob. 11TFCh. 12 - Prob. 12TFCh. 12 - Biofilms are difficult to treat and do not always...Ch. 12 - Prob. 14TFCh. 12 - Prob. 15TFCh. 12 - Construct a paragraph describing the...Ch. 12 - Prob. 2CTQCh. 12 - Antibiotic-resistance genes, as well as other...Ch. 12 - Prob. 4CTQCh. 12 - What is the significance of the bottom row in...Ch. 12 - Figure 12.5. Where could penicillinase affect each...Ch. 12 - From chapter 6, process figure 6.14a. Describe as...Ch. 12 - Prob. 1CM
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- Which of the following is NOT used to treat active viral disease? a. Vaccines b. Antiviral drugs c. Antibiotics d. Phage therapyarrow_forwardIn terms of microbial pathogenicity, molecular Koch's postulates are a set of experimental criteria that show: A microbe is the aetiological agent of a disease A gene encodes a product that contributes to disease A gene encodes a product that contributes to immunity to a disease A mutation does not contribute to diseasearrow_forwardIn Hershey and Chase’s experiment investigating which biological molecule carries genetic information, they found that phage DNA with radiolabeled phosphorus was retained in bacterial cells after transduction. To conclude that DNA is the genetic material, what assumption did they have to make? (photo linked) A. Protein does not enter the bacterium during transduction. B. DNA does not stay in the media after transduction. C. All of the phage DNA was radiolabeled. D. Bacteria can be transduced by phage.arrow_forward
- Alfred Hershey and Martha Chase performed experiments to show that A: the genetic material was DNA contained in the bacteriophage, which entered bacteria during phage infection. B:the genetic material was RNA contained in the bacteriophage, which entered bacteria during phage infection C:the genetic material was protein contained in the bacteriophage, which entered bacteria during phage infection D:none of these choices are correctHomework question i am lost onarrow_forwardDefine the following terms: a. negative sense RNA virus b. vDNA c. proviral DNA d. macropinocytosis e. temperate phagearrow_forwardThe development of antiviral therapies offers unique challenges. Describe why many existing antiviral drugs cause severe side effects in patients? It is often difficult to differentiate between viral and bacterial diseases with similar symptoms. In order to ensure proper diagnosis, symptoms should be observed for which two characteristics?arrow_forward
- The five stages of the bacteriophage lytic cycle occur in this order:a. penetration, attachment, release, maturation, biosynthesis.b. attachment, penetration, release, biosynthesis, maturation.c. biosynthesis, attachment, penetration, maturation, release.d. attachment, penetration, biosynthesis, maturation, release.e. penetration, biosynthesis, attachment, maturation, release.arrow_forwardWhich of the following best describes the mechanism of action of the antibiotic streptomycin? A. it disrupts protein synthesis in resistant bacteria. B. Streptomycin inhibits cell wall synthesis in all bacterial species. C. Streptomycin creates mutations in bacteria which cause them to become resistant. D. It disrupts protein synthesis in nonresistant bacteria.arrow_forwardAntibotic/drug resistance in bacteria results from mutations induced by the anitbiotic which enhance fitness of the bacteria ensuring their survival. a) True b) Falsearrow_forward
- Which of the following statements is true about a vector?a) Plasmids, phages can be used as vectorsb) All vectors are plasmidsc) Cyanobacteria can also be used as vectorsd) Fungi can also be used as vectorsarrow_forwardPhage conversion in which viruses add genes to a bacterial cell can be considered to be a form of a. standard inheritance. b. horizontal gene transfer. c. vertical gene transfer. d. parasitism.arrow_forwardIn Hershey and Chase’s experiment investigating which biological molecule carries genetic information, they found that phage DNA with radiolabeled phosphorus was retained in bacterial cells after transduction. To conclude that DNA is the genetic material, what assumption did they have to make? A. Protein does not enter the bacterium during transduction. B. DNA does not stay in the media after transduction. C. All of the phage DNA was radiolabeled. D. Bacteria can be transduced by phage.arrow_forward
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