Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 12, Problem 10MCQ
Summary Introduction
Introduction:
Antimicrobial agents are commonly used to treat microbial infections. The “therapeutic index” defines the ratio of the dose of drug, which is lethal or toxic to humans to its median effective dose.
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Choose the combination of answers that most accurately completes the statement. An antimicrobial drug with a ___________ therapeutic index is a better choice than one with a ___________ therapeutic index. a. low, high b. high, low
Choose the combination of answers that most accurately completes the statement. Which statement is not an aim in the use of drugs in antimicrobial chemotherapy? The drug should a. have selective toxicity b. be active even in high dilutions c. be broken down and excreted rapidly d. be microbicidal
Match the antimicrobial drug class to its action.
1. Macrolides
A. Inhibit cell wall synthesis
2. Tetracyclines B. Disrupt cell membrane integrity
3. Quinolones
C. Block folic acid synthesis
4. Sulfa Drugs D. Interrupts nucleic acid synthesis
2018 Pearson Education, Inc.
E. Inhibits protein synthesis
5. Penicillins
6. Polymyxin
تطابق فئة الأدوية المضادة للميكروبات لعملها.
تمنع تركيب جدار الخلية
تعطیل سلامة غشاء الخلية
كتلة تخليق حمض الفوليك
يقطع تحليق الحمض النووي
يمنع تخليق البروتين
Chapter 12 Solutions
Microbiology: A Systems Approach
Ch. 12.1 - State the main goal of antimicrobial treatment.Ch. 12.1 - Identify sources of the most commonly used...Ch. 12.1 - Summarize two methods for testing antimicrobial...Ch. 12.1 - Prob. 4AYPCh. 12.2 - Prob. 5AYPCh. 12.2 - Describe the five major targets of antimicrobial...Ch. 12.2 - Identify which categories of drugs are most...Ch. 12.3 - Prob. 8AYPCh. 12.3 - Trace the development of penicillin...Ch. 12.3 - Prob. 10AYP
Ch. 12.3 - Prob. 11AYPCh. 12.3 - Prob. 12AYPCh. 12.3 - Prob. 13AYPCh. 12.3 - Identify the cellular target of quinolones, and...Ch. 12.3 - Prob. 15AYPCh. 12.3 - Prob. 16AYPCh. 12.3 - Prob. 17AYPCh. 12.3 - Prob. 18AYPCh. 12.3 - Describe two major modes of action of antiviral...Ch. 12.4 - Prob. 20AYPCh. 12.4 - Prob. 21AYPCh. 12.4 - Discuss at least three novel antimicrobial...Ch. 12.5 - Distinguish between drug toxicity and allergic...Ch. 12.5 - Prob. 24AYPCh. 12 - Prob. 1MCQCh. 12 - Prob. 2MCQCh. 12 - Prob. 3MCQCh. 12 - Microbial resistance to drugs is acquired through...Ch. 12 - Prob. 5MCQCh. 12 - Prob. 6MCQCh. 12 - Prob. 7MCQCh. 12 - Which of the following modes of action would be...Ch. 12 - Prob. 9MCQCh. 12 - Prob. 10MCQCh. 12 - Prob. 11TFCh. 12 - Prob. 12TFCh. 12 - Biofilms are difficult to treat and do not always...Ch. 12 - Prob. 14TFCh. 12 - Prob. 15TFCh. 12 - Construct a paragraph describing the...Ch. 12 - Prob. 2CTQCh. 12 - Antibiotic-resistance genes, as well as other...Ch. 12 - Prob. 4CTQCh. 12 - What is the significance of the bottom row in...Ch. 12 - Figure 12.5. Where could penicillinase affect each...Ch. 12 - From chapter 6, process figure 6.14a. Describe as...Ch. 12 - Prob. 1CM
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- The list below choose all the concerns surrounding antimicrobial use. A. toxicity B. disruption of normal flora C. allergic reactions D. tolerance of effective dosearrow_forwardWhich clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug? Select one: a.prophylaxis against infection after a surgical procedure b.The treatment of strep throat caused by culture identified as Streptococcus pyogenes c.None of the Above d.the treatment of a polymicrobial mixed infection in the intestine e.Empiric therapy (based on educated guesswork) of pneumonia while waiting for culture resultsarrow_forwardWhich ONE of the following best describes ciprofloxacin? Select one: A. Active against Streptococcus pneumoniae B. An inhibitor of RNA synthesis C. An antimicrobial prodrug D. A natural product produced by Streptomyces spp. E. Subject to new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effectsarrow_forward
- Which of the following is NOT a property of an antimicrobial agent? a. Must have a known concentration over a period of time required to eliminate a pathogen b. all choices are correct c. must be selectively toxic d. Must have a favorable chemotherapeutic indexarrow_forwardWhich of the following medication doses are calculated by using the area under the curve method? A. Carboplatin B. Dacarbazine C. Ifosfamide D. Cyclophosphamidearrow_forwardWhich of the following is not a factor that should be considered when selecting a antimicrobial drug? A. The nature of the microbe causing the infection B. The overall medical condition of the patient C. The origin of the drug D. The degree of susceptibility of the microbe to that drugarrow_forward
- A compound synthesized by bacteria or fungi that destroys or inhibitsthe growth of other microbes is a(n)a. synthetic drug b. antibiotic c. antimicrobial drug d. competitive inhibitorarrow_forwardA broad- spectrum antimicrobial drug would be a drug that attacks many different microbial sites. True or false.arrow_forwardMany antibacterial hand soaps contain the chemical agent _____ , which belongs to the _____ antimicrobial category. a. sodium hypochlorite; halogen b. triclosan; phenolic c. sodium chlorite; halogen d. ethanol; alcoholarrow_forward
- 1. a. Disk A b. Disk B c. Disk C d. Disk D 2. a. Strip A with MIC at 0.25 μg/mL b. Strip B with MIC at 0.064 μg/mL c. Strip C with MIC at 0.075 μg/mL d. All of the strips show equal antimicrobial efficacyarrow_forwardBroad-spectrum drugs target a wide variety of bacterial pathogens. Even when the broad-spectrum drug is capable of killing a target pathogen, it may not be the best treatment. Which statement best explains why a broad spectrum drug might be an undesirable treatment choice? Broad-spectrum antimicrobials are usually toxic to the host cells. Broad-spectrum antimicrobials only work if they are used shortly after the infection begins. Broad-spectrum antimicrobials may kill much of the normal microbiota. Broad-spectrum antimicrobials are not able to kill bacteria that are in their log phase of growth. Broad-spectrum antimicrobials may stimulate excess growth of the normal microbiota.arrow_forwardAR is a fair skinned patient who is planning a sunny vacation to the tropics in two weeks. They do not have any allergies or medical conditions and are looking for "maximum protection". They are asking for advice on what they should purchase for insect repellant and sun protection. Which pair of products should be sold to the patient? a. DEET 30% insect repellent/SPF 50 sunscreen b. DEET 99% insect repellent/SPF 50 sunscreen C. natural insect repellent/SPF 15 sunscreen d. DEET 10% insect repellent/SPF 30 sunscreenarrow_forward
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