Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Question
Chapter 11.7, Problem 2R
Summary Introduction
To review:
The comparison of tumor suppressors and oncogenes products in the cell cycle of normal and cancerous cells.
Introduction:
The function of tumor-suppressor genes is to suppress the proliferation of tumors. These genes products usually take part in the cell cycle. They perform the function of checkpoints in the cell cycle and do not allow the replication, cell division of damaged deoxyribonucleic acid (DNA) in the cells. Oncogenes are the potential genes that could transform into a cancer-causing gene. The reason lies in the fact because these genes usually concern themselves with the rate of cell growth.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
What role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with DNA damage?
How does the dysregulation of cell cycle checkpoints contribute to the development of cancer?
How do BRCA1 and BRCA2 function in regard to cell proliferation (are they proto-oncogenes, oncogenes, or tumor suppressor genes)?
Chapter 11 Solutions
Life: The Science of Biology
Ch. 11.1 - Prob. 1RCh. 11.1 - Prob. 2RCh. 11.1 - Prob. 3RCh. 11.2 - Prob. 1RCh. 11.2 - Prob. 2RCh. 11.2 - Prob. 3RCh. 11.2 - Prob. 4RCh. 11.3 - Prob. 1RCh. 11.3 - Prob. 2RCh. 11.3 - Prob. 3R
Ch. 11.3 - Prob. 4RCh. 11.3 - Prob. 5RCh. 11.4 - Prob. 1RCh. 11.4 - Prob. 2RCh. 11.4 - Prob. 3RCh. 11.4 - Prob. 4RCh. 11.5 - Prob. 1RCh. 11.5 - Prob. 2RCh. 11.5 - Prob. 3RCh. 11.5 - Prob. 4RCh. 11.6 - Prob. 1RCh. 11.6 - Prob. 2RCh. 11.6 - Prob. 3RCh. 11.7 - Prob. 1RCh. 11.7 - Prob. 2RCh. 11.7 - Prob. 3R
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Describe how Ras and p53 can alter the simplified genetic pathway controlling cell division shown below. For each of the two genes, would uncontrolled cell division result from a loss-of-function or a gain-of-function mutation? growth factors - receptors - cyclins - cyclin-dependent kinases - cell divisionarrow_forwardIs PI3K a proto-oncogene or a tumor suppressor gene? Why?arrow_forwardWhy does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?arrow_forward
- What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?arrow_forwardWhat would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53 functions?arrow_forwardDescribe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forward
- What aspects of the cell cycle are controlled by the G1, G2, and M checkpoints? How are cyclins and cyclin-dependent protein kinases involved in cell cycle regulation at checkpoints?arrow_forwardHow do oncogenes differ from tumor suppressor genes?arrow_forwardHow does the p53 tumor-suppressor protein control cell-cyclecheckpoints?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
cell division of meiosis and mitosis; Author: Stated Clearly;https://www.youtube.com/watch?v=A-mFPZLLbHI;License: Standard youtube license