Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 10, Problem 21P
Chimpanzees have a set of hemoglobin genes very similar to the set in humans that was shown in Fig. 10.11. For example, the genomes of both species have α1, α2, β, Gγ, Aγ, δ, ε, and ζ genes.
| a. | Of the human and chimpanzee hemoglobin genes, which would be considered homologous? Which paralogous? Which orthologous? |
| b. | When comparing genomes, geneticists would usually like to know which genes are the most likely to perform similar if not identical functions in different species. This determination can be somewhat complicated in the case of gene families. Would paralogous genes or orthologous genes be more likely to be functionally equivalent? Explain. |
| c. | Which gene would have the greatest degree of |
| d. | Rationalize the pattern of hemoglobin genes in the two species with the existence of duplication and divergence events among the hemoglobin genes depicted in Fig. 10.12. |
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The human genome contains more than a million copies of the Alu transposable element. Comparative genomics reveals that the Alu element is found only in the clade of mammals that includes primates, tree shrews,rodents, and rabbits. a. What does the observation that the Alu transposon is limited to this clade reveal about its origin and method of spread among species? b. At many sites in the genome, an Alu element is present in humans but absent in chimpanzees, while at many other sites an Alu element is present in chimpanzees but absent in humans. What are two hypotheses that could explain this situation? For any particular site,how could the hypotheses be distinguished?
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Chapter 10 Solutions
Genetics: From Genes to Genomes
Ch. 10 - Prob. 1PCh. 10 - List three independent techniques you could use to...Ch. 10 - Figure 10.2a has numbers indicating the...Ch. 10 - Which of the enzymes from the following list would...Ch. 10 - Prob. 5PCh. 10 - a. What sequence information about a gene is...Ch. 10 - Why do geneticists studying eukaryotic organisms...Ch. 10 - Consider three different kinds of human libraries:...Ch. 10 - The human genome has been sequenced, but we still...Ch. 10 - This problem investigates issues encountered in...
Ch. 10 - For the sake of simplicity, Fig. 10.4 omitted one...Ch. 10 - Give two different reasons for the much higher...Ch. 10 - Using a cDNA library, you isolated two different...Ch. 10 - The figure that follows shows part of a modified...Ch. 10 - In Problem 14, cDNAs F and G could not be found in...Ch. 10 - Fig. 10.10 presents a model for exon shuffling in...Ch. 10 - An interesting phenomenon found in vertebrate DNA...Ch. 10 - a. If you found a zinc-finger domain which...Ch. 10 - Prob. 19PCh. 10 - In the human immune system, so-called B cells can...Ch. 10 - Chimpanzees have a set of hemoglobin genes very...Ch. 10 - Complete genome sequences indicate that the human...Ch. 10 - On your computers browser, view the page accessed...Ch. 10 - Prob. 24PCh. 10 - Prob. 25PCh. 10 - Certain individuals with mild forms of...Ch. 10 - The 1 and 2 genes in humans are identical in their...Ch. 10 - Prob. 28P
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