In the experiment below, mice were treated with a virus that inhibited expression of angiopoietin 2, MMP3 and MMP10 in the lung or with a control virus (Mock). Breast cancer cells that express the gene luciferase were then injected into the mammary glands of the mice. The metstasis of the tumors to the lungs could then be measured by imaging the presence of luciferase in the lungs. In 5-6 sentences, explain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.
In the experiment below, mice were treated with a virus that inhibited expression of angiopoietin 2, MMP3 and MMP10 in the lung or with a control virus (Mock). Breast cancer cells that express the gene luciferase were then injected into the mammary glands of the mice. The metstasis of the tumors to the lungs could then be measured by imaging the presence of luciferase in the lungs. In 5-6 sentences, explain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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In the experiment below, mice were treated with a virus that inhibited expression of angiopoietin 2, MMP3 and MMP10 in the lung or with a control virus (Mock). Breast cancer cells that express the gene luciferase were then injected into the mammary glands of the mice. The metstasis of the tumors to the lungs could then be measured by imaging the presence of luciferase in the lungs. In 5-6 sentences, explain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.
Transcribed Image Text:A
Mock
Angpt2/MMP3/10
B
-RNAI
Relative photon flux
4000
3000
2000
1000
W 1
0
Weeks: 0
- Mock
W 2
2
Angpt2/MMP3/10-RNAi
W 3
4
6
W4
8
W 6
20000
18000
16000
14000
12000
10000
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