You are working with a fly hair cell developmental system. This Notch/Delta-regulated system results in clusters of cells where the central one differentiates into a specialized hair cell. To better understand this system you have tagged the C-terminal cytoplasmic domain of Notch with GFP. You have done a forward genetic screen to look for mutants that have unusual phenotypes in this Notch system. The first one is a mutation in Notch itself. This mutant is in the ADAM10 cleavage site and blocks proteolysis. Draw the expected outcome for such a mutant: GFP localization and developmental outcome 24hr after differentiation. WT before differentiation WT 24 hours after differentiation

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Post a short summary about the assigned video posted below https://www.youtube.com/watch?v=5-bN7qB_kck

What would the answers to each of the questions be?

“Hello, I would like to make an appointment to see the doctor. I am having some chest pain, and find it a bit hard to breathe.”

KEY: Hydrophobic interactions: Salt bridge: Covalent bonds: Hydrogen bonding: Metal ion coordination: 9. 10What components of the plasma membrane might you drug interact with? Explain can use as many components as you need (may need more or less). Component 1 and why: Component 2 and why: Component 3 and why:

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