Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 9, Problem 11PDQ

Consider the case where a mutation occurs that disrupts translation in a single human mitochondrion found in the oocyte participating in fertilization. What is the likely impact of this mutation on the offspring arising from this oocyte?

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Name three possible factors contributing to early asymmetries in a developing embryo (i.e. what are the kinds of things early on that lead to the development of the body axes - dn, a/p, l/r, etc)? In the fruit fly drosophila melanogaster, the anterior-to-posterior body axis becomes segmented into distinct regions. explain the role of the genes bicoid and nanos in this process.
In drosophila, a recessive mutation (m-) of a maternal effect gene results in an abnormalphenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonicdevelopment. Homozygous (m-m-) males, however, can still produce viable sperm. Using m+ todenote a normal gene, determine the genotypes and phenotypes of the F1s produce by a crossbetween a heterozygous female and a recessive male. From the offspring, backcross the recessivefemale with the paternal strain. What are the genotypes and phenotypes of the F2s?
Discuss how the anterior portion of the anteroposterior axis is established in Drosophila. What aspects of oogenesis are critical in establishing this axis? What do you think would happen if the bicoid mRNA was not trapped at the anterior end but instead diffused freely throughout the oocyte?

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Concepts of Genetics (12th Edition)

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY