Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 9, Problem 4NST
Summary Introduction
To explain: The phenomenon of the reduced mutation rate of mitochondrial DNA over generations.
Introduction: Mitochondria are inherited through the cytoplasm of mother in most organisms. Mitochondria carry their own DNA (deoxyribonucleic acid) and information about the genetic expression.
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All mutations in mitochondrial genes ultimately affect (whether directly or indirectly) the key function of mitochondria, which is to make ATP. Why then do mutations in different genes cause different diseases, with specific symptoms?
Some living organisms are under considerable pressure tostreamline their genomes for the sake of more efficientoperation. As a result, the mitochondria of eukaryotic species have lost, to one degree or another, the overwhelmingmajority of their genes. During this process, several hundred mitochondrial genes were transferred to the nucleargenome. Yet mitochondria still retain a genome with thecapacity to produce several electron transport proteins.Review mitochondrial electron transport and suggest areason why these energy-generating organelles retained thegenes to produce this set of molecules.
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Chapter 9 Solutions
Concepts of Genetics (12th Edition)
Ch. 9 - Chlamydomonas, a eukaryoric green alga, may be...Ch. 9 - In aerobically cultured yeast, a petite mutant is...Ch. 9 - DNA in human mitochondria encodes 22 different...Ch. 9 - Prob. 4NSTCh. 9 - Why did Marcia choose mitochondrial testing to...Ch. 9 - Marcia saw an ad on television for ancestry DNA...Ch. 9 - How much importance should we place on the results...Ch. 9 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 9 - Review the Chapter Concepts list on page 196. The...Ch. 9 - Streptomycin resistance in Chlamydomonas may...
Ch. 9 - A plant may have green, white, or green-and-white...Ch. 9 - In diploid yeast strains, sporulation and...Ch. 9 - Predict the results of a cross between ascospores...Ch. 9 - In Lymnaea, what results would you expect in a...Ch. 9 - In a cross of Lymnaea, the snail contributing the...Ch. 9 - In Drosophila subobscura, the presence of a...Ch. 9 - A male mouse from a true-breeding strain of...Ch. 9 - Consider the case where a mutation occurs that...Ch. 9 - What is the endosymbiotic theory, and why is this...Ch. 9 - In an earlier Problems and Discussion section (see...Ch. 9 - Mitochondrial replacement therapy (MRT) offers a...Ch. 9 - The specification of the anteriorposterior axis in...Ch. 9 - The maternal-effect mutation bicoid (bcd) is...Ch. 9 - (a) In humans the mitochondrial genome encodes a...Ch. 9 - Mutations in mitochondrial DNA appear to be...Ch. 9 - Researchers examined a family with an interesting...Ch. 9 - Payne, B. A. et al. (2013) present evidence that a...Ch. 9 - As mentioned in Section 9.3, mtDNA accumulates...Ch. 9 - Because offspring inherit the mitochondrial genome...
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- The mitochondrial genome of Chlamydomonas contains the lowest number of genes, 12, of all the species of green algae. However, only 7 proteins are produced inside these mitochondria. Which of the following statements is the best explanation for why only 7 proteins are made from the 12 genes In Chlamydomonas mitochondria? OA Five of the genes are redundant; another copy is expressed from the nuclear genome.. OB. Five of the genes are nonfunctional "pseudogenes". OC Five of the genes are transcribed, but not translated. OD. Five of the genes are coding for proteins that are translated in the cytoplasm. Reset Selectionarrow_forwardMitochondria contain their own genetic material. Mitochondrialmutations are inherited from mother to child, without anycontribution from the father. Why?arrow_forwardIs each of these statements true of chloroplast or mitochondrial genomes, both, or neither? a.contain tRNA genesarrow_forward
- Plant breeders have long appreciated the phenomenoncalled hybrid vigor or heterosis, in which hybridsformed between two inbred strains have increasedvigor and crop yield relative to the two parental strains.Starting in the 1930s, seed companies exploited the cytoplasmic male sterility (CMS) phenomenon in cornthat was described in Problem 17 so that they couldcheaply produce hybrid corn seed to sell to farmers.This type of CMS is caused by mutant mitochondrialgenomes that prevent pollen formation.a. How would CMS aid seed companies in producinghybrid corn seed?Dominant Rf alleles of a nuclear gene called Restorersuppress the CMS phenotype, so that Rf-containingplants with mutant mitochondrial genomes are malefertile.b. Describe a cross generating hybrid corn seed thatwould grow into fertile (self-fertilizing) plants.(Farmers planting hybrid seed want fertile plantsbecause corn kernels result from fertilized ovules.)c. One of the historical challenges in the commercialization of hybrid…arrow_forwardI have this same question, but the answer is supposed to involve mitochondrial uncoupling?arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of this genetic defect causes deformation of red blood cells. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. Assuming HWE, if 9% of an African population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria…arrow_forward
- How many copies of mitochondrial 16S rRNA gene are integrated in Human chromosomal DNA ?arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell…arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the dominant allele? Please show your work in order to receive credit.arrow_forward
- What is heteroplasmy? How it affects mitochondrial inheritance? Use specific examples to describe your results?arrow_forwardSickle-cell anemia is an interesting genetic disease. Normal homozygous individials (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to survive better than either of the homozygous conditions. 11% of an African population is born with a severe form of sickle-cell anemia (ss), What is the frequency of the recessive allele? Please show your work in orderarrow_forwardExplain how mutations in mitochondrial genes cause humandiseasesarrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY