Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 5, Problem 27RQ
The following terms have been applied to membrane carriers: specificity, competition, saturation. Why can these terms also be applied to enzymes? What is the major difference in how enzymes and carriers carry out their work?
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A transmembrane protein has the following properties: it has two binding sites, one for solute A and one for solute b. The protein can undergo a conformational change to switch between two states: either both binding sites are exposed exclusively on one side of the membrane or both binding sites are exposed exclusively on the other side of the membrane. The protein can switch between the two conformational states only if both binding sites are occupied or if both binding sites are empty, but cannot switch if only one binding site is occupied. What kind of protein do these properties define?
Proteins and phospholipids rarely exhibit transbilayer movement in membranes without an
input of energy.
True
False
A transmembrane protein has the following properties: it has two binding sites, one for solute A and one for solute b. The protein can undergo a conformational change to switch between two states: either both binding sites are exposed exclusively on one side of the membrane or both binding sites are exposed exclusively on the other side of the membrane. The protein can switch between the two conformational states only if both binding sites are occupied or if both binding sites are empty, but cannot switch if only one binding site is occupied. Do you need to specify any additional properties to turn this protein into a symport that couples the movement of solute A up its concentration gradient to the movement of solute b down its electrochemical gradient?
Chapter 5 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 5.1 - If the 58-kg Reference Woman has total body water...Ch. 5.1 - A mother brings her baby to the emergency room...Ch. 5.1 - Prob. 6CCCh. 5.1 - Two compartments are separated by a membrane that...Ch. 5.1 - Prob. 8CCCh. 5.1 - Prob. 9CCCh. 5.1 - Prob. 10CCCh. 5.3 - If the distance over which a molecule must diffuse...Ch. 5.3 - Prob. 12CCCh. 5.3 - Which is more likely to cross a cell membrane by...
Ch. 5.3 - Prob. 14CCCh. 5.3 - Prob. 15CCCh. 5.3 - Prob. 16CCCh. 5.4 - Positively charged ions are called _____, and...Ch. 5.4 - Name four functions of membrane proteins.Ch. 5.4 - Prob. 19CCCh. 5.4 - Prob. 20CCCh. 5.4 - If a channel is lined with amino acids that have a...Ch. 5.4 - Prob. 22CCCh. 5.4 - Liver cells (hepatocytes) are able to convert...Ch. 5.4 - Prob. 24CCCh. 5.5 - What would you call a carrier that moves two...Ch. 5.5 - Prob. 26CCCh. 5.5 - Prob. 27CCCh. 5.5 - Name the two membrane protein families associated...Ch. 5.5 - Prob. 29CCCh. 5.6 - Prob. 30CCCh. 5.6 - Prob. 31CCCh. 5.6 - Prob. 32CCCh. 5.6 - Prob. 33CCCh. 5.7 - Prob. 34CCCh. 5 - Using what you learned about the naming...Ch. 5 - Prob. 2CCCh. 5 - Prob. 3CCCh. 5 - Prob. 1RQCh. 5 - Distinguish between active transport and passive...Ch. 5 - Which of the following processes are examples of...Ch. 5 - List four factors that increase the rate of...Ch. 5 - List the three physical methods by which materials...Ch. 5 - A cotransporter is a protein that moves more than...Ch. 5 - Prob. 7RQCh. 5 - Prob. 8RQCh. 5 - Prob. 9RQCh. 5 - What determines the osmolarity of a solution? In...Ch. 5 - Prob. 11RQCh. 5 - Prob. 12RQCh. 5 - Prob. 13RQCh. 5 - Prob. 14RQCh. 5 - The membrane potential at which the electrical...Ch. 5 - Prob. 16RQCh. 5 - Create a map of transport across cell membranes...Ch. 5 - Draw a large rectangle to represent the total body...Ch. 5 - What factors influence the rate of diffusion...Ch. 5 - Define the following terms and explain how they...Ch. 5 - Prob. 21RQCh. 5 - Prob. 22RQCh. 5 - Prob. 23RQCh. 5 - Prob. 24RQCh. 5 - Prob. 25RQCh. 5 - Prob. 26RQCh. 5 - The following terms have been applied to membrane...Ch. 5 - Prob. 28RQCh. 5 - NaCl is a nonpenetrating solute and urea is a...Ch. 5 - Prob. 30RQCh. 5 - Prob. 31RQCh. 5 - What is the osmolarity of half-normal saline (=...Ch. 5 - Prob. 33RQCh. 5 - Prob. 34RQ
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- The following are true statements regarding passive facilitated transport EXCEPT The process is always thermodynamically favorable. It uses the same driving force as that of active transport. The movement of solute acrosss the membrane is dictated by existing concentration or ion gradient. It requires a carrier protein which is an integral membrane protein.arrow_forwardUniporters and ion channels support facilitated transport across cellular membranes. Although both are examples of facilitated transport, the rates of ion movement via an ion channel are roughly 104- to 105-fold faster than the rates of molecule movement via a uniporter. What key mechanistic difference results in this large difference in transport rate? What contribution to free energy (ΔG) determines the direction of transport?arrow_forwardWhat would happen in each of the following cases where something related to intracellular transport is altered? Assume in each case that the protein involved is a soluble protein, not a membrane protein. State where each protein would be located and explain each of your answers. You add a signal sequence (for the Golgi) to the N-terminal end of a normally cytosolic protein. You change the hydrophobic amino acids in an ER signal sequence into other, hydrophobic, amino acids.arrow_forward
- The electrochemical gradient across the plasma membrane is important for cellular functions including protein transport and information transfer. Pinpoint the specific protein and explain how it maintains the electrochemical gradient.arrow_forwardOuabain is a specific inhibitor of the active transport of sodium ions out of the cell and is therefore a valuable tool in studies of membrane transport mechanisms. Which of the following processes in your own body would you expect to be sensitive to inhibition by ouabain? Explain your answer in each case. a) Facilitated diffusion of glucose into a muscle cell b) Active transport of dietary phenylalanine across the intestinal mucosa c) Uptake of potassium ions by red blood cells d) Active uptake of lactose by the bacteria in your intestinearrow_forwardDistinguish between simple diffusion (SD), facilitated diffusion (FD), and active transport (AT) across a membrane for the following questions. (a) Which processes are energy dependent? (b) Which processes need some kind of carrier protein(s)? (c) Which processes can be saturated by substrate? (d) Which processes can establish a concentration gradient? (e) How much energy does it take to transport an uncharged substrate in, if its starting inside concentration is 10-fold greater than outside?arrow_forward
- In the experimental conditions described below, how many molecules of dextrose do you have to add to the extracellular fluid in order to make it iso-osmotic relative to the intracellular fluid? Intracellular fluid: Number of water molecules = 60 Number of Dextrose molecules = 6 Number of Sucrose molecules = 2 Extracellular fluid: Number of water molecules = 160 Number of dextrose molecule = ???? Number of Sucrose molecules = 0 Enter the number of molecules of dextrose in your answer (format: for 7 enter 7 or 7.00, for 7.5 enter 7.5 or 7.50, for 7.3333 enter 7.33 etc...).arrow_forwardA scaffold protein can serve as a platform to accommodate a collection of enzymes involved in catalyzing multi-step reactions. Imagine a scaffold protein that anchors its soluble enzymes to be located near the cytoplasmic membrane. What interactions does the scaffold protein likely use to achieve this? Electrostatic interactions through a domain inserted into the membrane, and hydrophobic interactions with the enzymes. O Hydrophobic interactions through a domain inserted into the membrane, and hydrophobic interactions with the enzymes. O Electrostatic interactions through a domain inserted into the membrane, and electrostatic interactions with the enzymes. O Hydrophobic interactions through a domain inserted into the membrane, and electrostatic interactions with the enzymes.arrow_forwardSome antibiotics act as carriers that bind an ion on one side of a membrane, diffuse through the membrane, and release the ion on the other side. The graph shows the conductance of a lipid-bilayer membrane with a carrier antibiotic as a function of temperature. Conductance 40 39 38 Temperature (°C) 37 36 What can you conclude about the effect of a carrier antibiotic on the conductance of the lipid-bilayer membrane? A carrier antibiotic decreases the conductance of a lipid bilayer, regardless of temperature. A carrier antibiotic can shuttle ions across a membrane only when the lipid bilayer is quite rigid. A carrier antibiotic increases the conductance of a lipid bilayer, regardless of temperature. O A carrier antibiotic can shuttle ions across a membrane only when the lipid bilayer is highly fluid.arrow_forward
- Ms. Sassa, a biology professor, wanted to demonstrate to her students the applicability of a dialyzing membrane (DM) as a model for the cell membrane by enclosing an aqueous solution in a DM bag and immersing in a beaker containing a different solution. Substances available which are permeable to the DM include 0.02 M NaCl, 0.03 M glucose, and 0.01 M glucose. The only substance available which is completely impermeable to the DM is the 0.01 M lactose. Using the substances given and materials such as a beaker, stirring rod, and string, draw ONLY ONE set-up that can be demonstrated by Ms. Sassa that will satisfy ALL of the following conditions: a. No solute will exhibit a net diffusion out of the cell. b. Glucose will exhibit a net diffusion into the cell. c. NaCl will exhibit a zero net movement. d. No net movement of lactose from the inside to outside of the cell. Make sure to label properly the substance inside the beaker and inside the DM bag.arrow_forwardThe transport of a molecule is investigated using two chambers (left and right) separated by a synthetic membrane containing transport proteins. A solution containing varying concentrations of the molecule is added to the left side while pure water is added to the right. The transport rate of the molecule is determined by measuring the concentration of molecule that accumulates on the right side. The following table summarizes the transport rate of the molecule at various concentrations. Based on this you can conclude: a) the molecule is most likely transported by facilitated diffusion b) the molecule is moving across the membrane by passive transport c) the membrane is freely permeable to the molecule d) the molecule is most likely transported by active transportarrow_forwardInhibition of the Na,K-ATPase might reasonably result in which of the following: a.) gradual cellular accumulation of K+ b.) gradual decrease in cytoplasmic Na+ c.) cell shrinkage d.) hyperpolarization of the membrane potential e.) reduced activity of many secondary active transportersarrow_forward
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