Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 5, Problem 20RQ
Define the following terms and explain how they differ from one another: specificity, competition, saturation. Apply these terms in a short explanation of facilitated diffusion of glucose.
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Name the three classes of membrane transport proteins. Explain which one or ones of these classes is able to move glucose and which can move bicarbonate (HCO3−) against an electrochemical gradient. In the case of bicarbonate, but not glucose, the ΔG of the transport process has two terms. What are these two terms, and why does the second not apply to glucose? Why are cotransporters often referred to as examples of secondary active transport?
(b) The GLUT system is highly selective for glucose. It also speeds up the rate of glucose
transport across the membrane by as much as 100-fold when compared to the passive diffusion
of glucose across a bilayer in the absence of any transport system. While impressive, this rate of
transport is much slower than purely diffusion limited rate of movement (ie. the fastest a
molecule can move by diffusion). Given this fact, on the blank plot below draw the expected
relationship between the rate of GLUT-mediated transport and increasing [glucose]? Use the
space below the graph to explain your answer.
fast
Transport Rate
slow
low
[glucose]
high
(c) Next, use a dashed line on the same plot above to draw the shape of the curve when the
amount of GLUT transporters in the membrane is cut in half. Briefly explain your answer in the
space provided below the graph.
Name the three classes of membrane transport proteins. Explain which one or ones of these classes is able to move glucose and which can move bicarbonate (HCO3 −) against an electrochemical gradient. In the case of bicarbonate, but not glucose, the ΔG of the transport process has two terms.What are these two terms, and why does the second not apply to glucose? Why are cotransporters often referred to as examples of secondary active transport?
Chapter 5 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 5.1 - If the 58-kg Reference Woman has total body water...Ch. 5.1 - A mother brings her baby to the emergency room...Ch. 5.1 - Prob. 6CCCh. 5.1 - Two compartments are separated by a membrane that...Ch. 5.1 - Prob. 8CCCh. 5.1 - Prob. 9CCCh. 5.1 - Prob. 10CCCh. 5.3 - If the distance over which a molecule must diffuse...Ch. 5.3 - Prob. 12CCCh. 5.3 - Which is more likely to cross a cell membrane by...
Ch. 5.3 - Prob. 14CCCh. 5.3 - Prob. 15CCCh. 5.3 - Prob. 16CCCh. 5.4 - Positively charged ions are called _____, and...Ch. 5.4 - Name four functions of membrane proteins.Ch. 5.4 - Prob. 19CCCh. 5.4 - Prob. 20CCCh. 5.4 - If a channel is lined with amino acids that have a...Ch. 5.4 - Prob. 22CCCh. 5.4 - Liver cells (hepatocytes) are able to convert...Ch. 5.4 - Prob. 24CCCh. 5.5 - What would you call a carrier that moves two...Ch. 5.5 - Prob. 26CCCh. 5.5 - Prob. 27CCCh. 5.5 - Name the two membrane protein families associated...Ch. 5.5 - Prob. 29CCCh. 5.6 - Prob. 30CCCh. 5.6 - Prob. 31CCCh. 5.6 - Prob. 32CCCh. 5.6 - Prob. 33CCCh. 5.7 - Prob. 34CCCh. 5 - Using what you learned about the naming...Ch. 5 - Prob. 2CCCh. 5 - Prob. 3CCCh. 5 - Prob. 1RQCh. 5 - Distinguish between active transport and passive...Ch. 5 - Which of the following processes are examples of...Ch. 5 - List four factors that increase the rate of...Ch. 5 - List the three physical methods by which materials...Ch. 5 - A cotransporter is a protein that moves more than...Ch. 5 - Prob. 7RQCh. 5 - Prob. 8RQCh. 5 - Prob. 9RQCh. 5 - What determines the osmolarity of a solution? In...Ch. 5 - Prob. 11RQCh. 5 - Prob. 12RQCh. 5 - Prob. 13RQCh. 5 - Prob. 14RQCh. 5 - The membrane potential at which the electrical...Ch. 5 - Prob. 16RQCh. 5 - Create a map of transport across cell membranes...Ch. 5 - Draw a large rectangle to represent the total body...Ch. 5 - What factors influence the rate of diffusion...Ch. 5 - Define the following terms and explain how they...Ch. 5 - Prob. 21RQCh. 5 - Prob. 22RQCh. 5 - Prob. 23RQCh. 5 - Prob. 24RQCh. 5 - Prob. 25RQCh. 5 - Prob. 26RQCh. 5 - The following terms have been applied to membrane...Ch. 5 - Prob. 28RQCh. 5 - NaCl is a nonpenetrating solute and urea is a...Ch. 5 - Prob. 30RQCh. 5 - Prob. 31RQCh. 5 - What is the osmolarity of half-normal saline (=...Ch. 5 - Prob. 33RQCh. 5 - Prob. 34RQ
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Discuss the mechanisms that cells employ to create a concentration gradient to ensure continual uptake of glucose from the bloodstream.arrow_forwardNumber of glucose carrier proteins in membrane Glucose diffusion rate (mM/sec) 300 0.0015 500 0.0023 700 0.0031 900 0.0040 How does increasing the number of glucose carrier proteins affect glucose diffusion rate?arrow_forwardInhibition of the Na,K-ATPase might reasonably result in which of the following: a.) gradual cellular accumulation of K+ b.) gradual decrease in cytoplasmic Na+ c.) cell shrinkage d.) hyperpolarization of the membrane potential e.) reduced activity of many secondary active transportersarrow_forward
- # 4: With regard to the Na*-Glucose Symporter (aka Sodium-Glucose Co-transporter), Which of the two solute molecules (Glucose or Sodium) is being transported against its concentration or electrochemical gradient? Since that solute is being transported against its gradient, what is providing the energy to actively transport it in this specific mechanism?arrow_forwardDefine extracellular material (ECM). Explain how matrix metalloproteinases and tissue inhibitor of metalloproteinases regulates ECMarrow_forwardGlucose transporters are either open to the extracellular side or open to the intracellular side of the membrane but never both at the same time. True or False? Movement of an ion against or up its concentration gradient is exergonic. True or False? If an amino acid is transported into intestinal epithelial cells through a transporter that is able to concentrate the amino acid using a sodium ion moving down its gradient, this transporter is an example of primary active transport. True or False? The maximum gradient a primary active transporter can build has a potential energy which in magnitude is greater than or equal to the magnitude of the energy released by ATP hydrolysis. True or False?arrow_forward
- Illustrate the diffusion of glucose between two compartments of equal volume separated by a permeable barrier?arrow_forwardIn the stomach, parietal cells are responsible for the formation of the gastric juice. During acid secretion, the pH in the stomach is estimated to be pH = 2, whereas parietal cells maintain an intracellular pH =7.35. The transmembrane potential of parietal cells is typically -70 mV. Body temperature 37°C. 1) Calculate the proton gradient concentration across the parietal membrane 2) Calculate the free energy change associated with the secretion of 1 mole of H* 3) Do you think that Ht transport can be driven by ATP hydrolysis at the ratio of one molecule of ATP per H* transported? You can use your textbook or other sources to check AG for ATP hydrolysis 4) If H* where free to move back to into the cell, calculate the membrane potential that would be required to prevent them to do soarrow_forwardO Att Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Nat concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Nat ions into the cell to the "uphill" transport of glucose into the cell. If the Nat concentration outside the cell ([Na lout) is 161 mM and that inside the cell ([Na* Jm) is 17.0 mM, and the cell potential is -50.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. What is the maximum ratio of (glucose] to [glucoselout 10.62 kJ AG gluc mol that could theoretically be produced if the energy Incorrect coupling were 100% efficient? O 1.13 8.24 3800 2.6 x 10 Incorrectarrow_forward
- Intestinal epithelial cells pump glucose into the cell against its concentration gradient using the Nat-glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. If the Na+ concentration outside the cell ([Na+]out) is 155 mM and that inside the cell ([Na+ lin) is 21.0 mM, and the cell potential is -52.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C. AGgluc = kJ mol What is the maximum ratio of [glucose] in to [glucose]out that could theoretically be produced if the energy coupling were 100% efficient? O 2700 7.89 O 1.14 3.7 x 10-4arrow_forwardDescribe the symport process by which cells lining the small intestine import glucose. What ion is responsible for the transport, and what two particular features facilitate the energetically favored movement of this ion across the plasma membrane?arrow_forwardIntestinal epithelial cells pump glucose into the cell against its concentration gradient using the Na+– glucose symporter. Recall that the Na+ concentration is significantly higher outside the cell than inside the cell. The symporter couples the "downhill" transport of two Na+ ions into the cell to the "uphill" transport of glucose into the cell. If the Na+ concentration outside the cell ([Na+]out) is 163 mM and that inside the cell ([Na+]in) is 21.0 mM, and the cell potential is −54.0 mV (inside negative), calculate the maximum energy available for pumping a mole of glucose into the cell. Assume the temperature is 37 °C.arrow_forward
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