Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4, Problem 36P
The following is a pedigree of a family in which a rare form of color blindness is found (filled-in symbols). Indicate as much as you can about the genotypes of all the individuals in the pedigree.
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Students have asked these similar questions
The pedigree shows inheritance of the autosomal recessive trait cystic fibrosis in a family. Family members who are
known to have the disease are represented by black shading.
I
1
2
3
4
II 1
3
4
6
8
7
III
1
2
3
4
5
6
7
Part A: Select the best answer from the boxes below to indicate the likely genotypes of the following individuals, where F
indicates the wild-type (usual) allele and f indicates the cystic fibrosis allele. The first part of their number (I, II or III)
indicates their generation or row, whilst the second part of their number (1-8) indicates the individual within that generation
or row.
|-4
Il-3
Il-8
III-3
The pedigree below shows a family with a history of an autosomal recessive genetic
disease with one individual's genotype indicated (G denotes the normal allele and g
denotes the disease-causing allele).
*
O 0
O 1/8
1/4
O 1/16
Individual 1's father is known to be heterozygous (*) and his mother is known to be
homozygous dominant. Other individuals in the pedigree may be carriers, but are not
marked. The question mark (?) indicates that you do not yet know anything about this
individual's phenotype with regard to the disease.
Part 1
What is the probability that individuals 1 and 2 will have a child (5) who is a male with the
disease (the child is unborn and the sex is not yet known)?
O 1/4
1
O 1/6
5
1/8
2
01/12
gg
3
Part 2
What is the probability that the daughter (female)(6) that individual 3 and 4 just had will have the
disease?
6
Define the pedigree symbol(s) associated with each of the following individuals. Please be as specific as possible. Be sure to indicate WHOSE pedigree symbols you are defining.
(i) II-1 and II-3
(ii) II-5
(iii) II-9-10
(iv) II-11
(v) IV-14 and IV-15
(vi) IV-18
Chapter 4 Solutions
Genetics: From Genes to Genomes
Ch. 4 - Choose the best matching phrase in the right...Ch. 4 - Humans have 46 chromosomes in each somatic cell....Ch. 4 - The figure that follows shows the metaphase...Ch. 4 - Human XX males who are sex-reversed because they...Ch. 4 - Researchers discovered recently that the sole...Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Indicate which of the cells numbered iv matches...Ch. 4 - a. What are the four major stages of the cell...Ch. 4 - Answer the questions that follow for each stage of...Ch. 4 - Can you think of anything that would prevent...
Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Which types of cell division mitosis, meiosis I,...Ch. 4 - Complete the following statements using as many of...Ch. 4 - The five cells shown in figure a e are all from...Ch. 4 - One of the first microscopic observations of...Ch. 4 - A person is simultaneously heterozygous for two...Ch. 4 - Assuming i that the two chromosomes in every...Ch. 4 - In the moss Polytrichum commune, the haploid...Ch. 4 - Can you think of anything that would prevent...Ch. 4 - Sister chromatids are held together through...Ch. 4 - The pseudoautosomal regions PARs of the X and Y...Ch. 4 - Remarkably, the platypus has 10 sex chromosomes,...Ch. 4 - Somatic cells of chimpanzees contain 48...Ch. 4 - In humans: a. How many sperm develop from 100...Ch. 4 - Women sometimes develop benign tumors called...Ch. 4 - In a certain strain of turkeys, unfertilized eggs...Ch. 4 - Imagine you have two pure-breeding lines of...Ch. 4 - A system of sex determination known as...Ch. 4 - In Drosophila, the autosomal recessive brown eye...Ch. 4 - Barred feather pattern is a Z-linked dominant...Ch. 4 - When Calvin Bridges observed a large number of...Ch. 4 - In a vial of Drosophila, a research student...Ch. 4 - In 1919, Calvin Bridges began studying an X-linked...Ch. 4 - In Drosophila, a cross was made between a...Ch. 4 - As we learned in this chapter, the white mutation...Ch. 4 - The following is a pedigree of a family in which a...Ch. 4 - Each of the four pedigrees that follow represents...Ch. 4 - The pedigree that follows indicates the occurrence...Ch. 4 - Duchenne muscular dystrophy DMD is caused by a...Ch. 4 - The X-linked gene responsible for DMD encodes a...Ch. 4 - Males have hemophilia when they are hemizygous for...Ch. 4 - In the Fast Forward Box Visualizing X Chromosome...Ch. 4 - Consider the following pedigrees from human...Ch. 4 - Several different antigens can be detected in...Ch. 4 - The ancestry of a white female tiger bred in a...Ch. 4 - The pedigree that follows shows the inheritance of...Ch. 4 - In 1995, doctors reported a Chinese family in...Ch. 4 - In cats, the dominant O allele of the X-linked...Ch. 4 - In marsupials like the opposum or kangaroo, X...Ch. 4 - The pedigree diagram below shows a family in which...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The following pedigree shows the pattern of inheritance of red-green color blindness in a family. Females are shown as circles and males as squares; the squares or circles of individuals affected by the trait are filled in black. What is the chance that a son of the third-generation female indicated by the arrow will be color blind if the father is not color blind? If he is color blind?arrow_forwardThis is a pedigree for a dominant trait caused by gene A in humans. Shaded symbols show individuals affected with the trait; non-shaded individuals are normal (aa). Among the progeny arising from the marriage of individual III-1, what proportion would be expected to show the trait? Among the progeny arising from the marriage of individual III-6, what proportion would be expected to show the trait?arrow_forwardCystic fibrosis is an autosomal recessive disorder that runs in Ann's family. Consider the figure of a pedigree of the known occurrences of cystic fibrosis in her family. Ann Filled (red) circles represent affected females. Filled (red) squares represent affected males. Unfilled (tan) circles, such as Ann's circle, represent symptomless females. Unfilled (tan) squares represent symptomless males.arrow_forward
- Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis? Unafflicted carriers Ann Answer Bank father aunt's husband grandmother sister unclearrow_forwardUsing the pedigree, assume that the disease is caused by an autosomal dominant allele, R. Give the genotype of the following individuals: (a) III-4 (the girl at lower right) (b) II-3 (the girl’s mother) (c) II-4 (the girl’s father)arrow_forwardThe following pedigree shows the incidence of ABO blood types in a family. Which individual(s) is/are a known homozygote for blood type? What is/are the possible genotype(s) of individual III-2? What is/are the possible genotype(s) of individual III-3?arrow_forward
- Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?arrow_forwardIn this pedigree chart, what is the genotype of individual III-1? (It's circled in blue.)arrow_forwardIn pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?arrow_forward
- Pedigree analysis is often used to determine mode of inheritance (dominant or recessive, for example). Be sure to read the "Tips for Pedigree Analysis" in Figure 14.15 in 34. your text. Consider the following pedigree for the trait albinism (lack of skin pigmentation) in three generations of a family. (Solid symbols represent individuals with albinism.) Complete the unlabeled pedigree by indicating the genotypes for all involved. From your knowledge of Mendelian inheritance, answer the questions that follow. a. Is this trait caused by a dominant or recessive allele? What is the evidence for your response?arrow_forwardCystic fibrosis is a genetic disease that causes an abnormal production of mucus which in turn can cause damage and infection to the lungs and other organs. In the following pedigree, black indicates all those persons afflicted with cystic fibrosis (square symbols are males, circles are females). There's a healthy couple and they have two children. One is a 23-year-old daughter with cystic fibrosis who is married to a 24-year-old male who is healthy. The other child is a 15-year-old son who is healthy After studying the pedigree, write a logical hypothesis suggesting the cause of cystic fibrosis in terms of dominant or recessive alleles. On the basis of your hypothesis, write an appropriate genotype for both of the parents. Using a Punnett square, what is the probability of the parents having a child with cystic fibrosis? If the daughter's husband is a carrier of cystic fibrosis, what is the probability that they have a child with cystic fibrosis? Show your Punnett square.arrow_forwardFrom a cross (Xyz) / (xYZ) x (xyz) / (xyz), where X,x, Y,y and Z,z represent alleles of three linked genes whose relative order is unknown, the least frequent classes of progeny are genotype (xyz) / (xyz) and (XYZ) / (xyz). What is the correct relative order of genes X, Y and Z? Answer using lowercase letters separated by a dash (-). Example: x-y-zarrow_forward
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