Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 4, Problem 31P
When Calvin Bridges observed a large number of offspring from a cross of white-eyed female Drosophila to red-eyed males he found very rare white-eyed females and red-eyed males among the offspring. He was able to show that exceptions resulted from non-disjunction, such that the white-eyed females had received two Xs from the egg and a Y from the sperm, while the red-eyed males had received no sex chromosome from the egg and an X from the sperm. What progeny would have arisen from these same kinds of nondisjunctional events if they had occurred in the male parent? What would their eye colors have been?
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When Calvin Bridges observed a large number of offspring from a cross of white-eyed female Drosophila tored-eyed males, he found very rare white-eyed femalesand red-eyed males among the offspring. He was ableto show that these exceptions resulted from nondisjunction, such that the white-eyed females had received twoXs from the egg and a Y from the sperm, while thered-eyed males had received no sex chromosome fromthe egg and an X from the sperm. What progeny wouldhave arisen from these same kinds of nondisjunctionalevents if they had occurred in the male parent? Whatwould their eye colors have been?
In Drosophila, a cross was made between a yellow-bodied male with vestigial wings and a wild-type (WT) female(brown body and normal wings). The F1 generation consisted of WT males and WT females. The F1 males and females were crossed, and the F2 progeny consisted of 16 yellow males with vestigial wings, 48 yellow males with WT wings, 15 brown males with vestigial wings, 49 WT males, 31 brown females with vestigial wings, and 97 WT females. Based on these results, explain the inheritance of the two genes (i.e. autosomal or sex-linked, dominant or recessive).
Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w) and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F1 females were wild type for all three traits, while the F1 males expressed the yellow-body and white eyes traits. The cross was carried to an F2 progeny and only male offspring were tallied. Based on the data shown here, a genetic map was constructed. a) Diagram the genotypes of the F1 parents. b) Construct a map, assuming the white is at locus 1.5 on the X-chromosome.
Phenotype
Male offspring
y + ct
9
+ w +
6
y w ct
90
+ + +
95
+ + ct
424
y w +
376
y + +
0
+ w ct
0
Chapter 4 Solutions
Genetics: From Genes to Genomes
Ch. 4 - Choose the best matching phrase in the right...Ch. 4 - Humans have 46 chromosomes in each somatic cell....Ch. 4 - The figure that follows shows the metaphase...Ch. 4 - Human XX males who are sex-reversed because they...Ch. 4 - Researchers discovered recently that the sole...Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Indicate which of the cells numbered iv matches...Ch. 4 - a. What are the four major stages of the cell...Ch. 4 - Answer the questions that follow for each stage of...Ch. 4 - Can you think of anything that would prevent...
Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Which types of cell division mitosis, meiosis I,...Ch. 4 - Complete the following statements using as many of...Ch. 4 - The five cells shown in figure a e are all from...Ch. 4 - One of the first microscopic observations of...Ch. 4 - A person is simultaneously heterozygous for two...Ch. 4 - Assuming i that the two chromosomes in every...Ch. 4 - In the moss Polytrichum commune, the haploid...Ch. 4 - Can you think of anything that would prevent...Ch. 4 - Sister chromatids are held together through...Ch. 4 - The pseudoautosomal regions PARs of the X and Y...Ch. 4 - Remarkably, the platypus has 10 sex chromosomes,...Ch. 4 - Somatic cells of chimpanzees contain 48...Ch. 4 - In humans: a. How many sperm develop from 100...Ch. 4 - Women sometimes develop benign tumors called...Ch. 4 - In a certain strain of turkeys, unfertilized eggs...Ch. 4 - Imagine you have two pure-breeding lines of...Ch. 4 - A system of sex determination known as...Ch. 4 - In Drosophila, the autosomal recessive brown eye...Ch. 4 - Barred feather pattern is a Z-linked dominant...Ch. 4 - When Calvin Bridges observed a large number of...Ch. 4 - In a vial of Drosophila, a research student...Ch. 4 - In 1919, Calvin Bridges began studying an X-linked...Ch. 4 - In Drosophila, a cross was made between a...Ch. 4 - As we learned in this chapter, the white mutation...Ch. 4 - The following is a pedigree of a family in which a...Ch. 4 - Each of the four pedigrees that follow represents...Ch. 4 - The pedigree that follows indicates the occurrence...Ch. 4 - Duchenne muscular dystrophy DMD is caused by a...Ch. 4 - The X-linked gene responsible for DMD encodes a...Ch. 4 - Males have hemophilia when they are hemizygous for...Ch. 4 - In the Fast Forward Box Visualizing X Chromosome...Ch. 4 - Consider the following pedigrees from human...Ch. 4 - Several different antigens can be detected in...Ch. 4 - The ancestry of a white female tiger bred in a...Ch. 4 - The pedigree that follows shows the inheritance of...Ch. 4 - In 1995, doctors reported a Chinese family in...Ch. 4 - In cats, the dominant O allele of the X-linked...Ch. 4 - In marsupials like the opposum or kangaroo, X...Ch. 4 - The pedigree diagram below shows a family in which...
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- Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w) and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F1 females were wild type for all three traits, while the F1 males expressed the yellow-body and white eyes traits. The cross was carried to an F2 progeny and only male offspring were tallied. Based on the data shown here, a genetic map was constructed. a) Diagram the genotypes of the F1 parents. b) Construct a map, assuming the white is at locus 1.5 on the X-chromosome *******ANSWER PART B NOT PART A!!!! Phenotype Male offspring y + ct 9 + w + 6 y w ct 90 + + + 95 + + ct 424 y w + 376 y + + 0 + w ct 0arrow_forwardIn Drosophila, a cross was made between a yellowbodied male with vestigial (not fully developed)wings and a wild-type female (brown body). The F1generation consisted of wild-type males and wild-typefemales. F1 males and females were crossed, and theF2 progeny consisted of 16 yellow-bodied males withvestigial wings, 48 yellow-bodied males with normalwings, 15 males with brown bodies and vestigialwings, 49 wild-type males, 31 brown-bodied femaleswith vestigial wings, and 97 wild-type females.Explain the inheritance of the two genes in questionbased on these results.arrow_forwardA cross was made between 2 Drosophila that have the wild phenotype. Their progenies were found to have the same phenotype. A sample was taken from 2000 progenies, each of which was crossed with a fly having purple eye color. Half of the cross gave only wild type flies and the other half gave 50% purple-eyed progeny. What were the genotypes of the original pairs of wild type flies?arrow_forward
- Another cross in Drosophila involved the recessive, X-linked genes yellow (y), white (w), and cut (ct). A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The F1 females were wild type for all three traits, while the F1 males expressed the yellow-body and white-eye traits. The cross was carried to an F2 progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed. Phenotype Male Offspring y + ct 9 + w + 6 y w ct 90 + + + 95 + + ct 424 y w + 376 y + + 0 + w ct 0 (a) Diagram the genotypes of the F1 parents. (b) Construct a map, assuming that white is at locus 1.5 on the X chromosome. (c) Were any double-crossover offspring expected? (d) Could the F2 female offspring be used to construct the map? Why or why not?arrow_forwardIn silkmoths (Bombyx mori), red eyes (re) and white-banded wings (wb) are encoded by two mutant alleles that are recessive to those that produce wild-type traits (re+ and wb+); these two genes are on the same chromosome. A moth homozygous for red eyes and white-banded wings is crossed with a moth homozygous for the wild-type traits. The F1 have wild-type eyes and wild-type wings. The F1 are crossed with moths that have red eyes and white-banded wings in a testcross. The progeny of this testcross are wild-type eyes, wild-type wings red eyes, wild-type wings wild-type eyes, white-banded wings red eyes, white-banded wings a. What phenotypic proportions would be expected if the genes for red eyes and for white-banded wings were located on different chromosomes? b. What is the rate of recombination between the gene for red eyes and the gene for white-banded wings?arrow_forwardIn Drosophila,, the curled mutation (cu, chromosome 3, position 50.0) results in wings that curl up, while ebony (e, chromosome 3, position 70.7) results in a dark body. True breeding, wild type females are mated with true breeding males with curled wings and ebony bodies. Considering Drosophila notation, which of the following correctly diagrams the F1 cross? X X 3+ cu e + X X e + + + + + cu e + O + ■ 3+ X X X X Y Y + + ■ cu cu cu ' + ■ cu ■ ' + e + e e e e e + cu +arrow_forward
- You are studying ear shape in dogs (with XY se x determination) and cross a true-breeding pointed-ear female to a true-breeding floppy-ear male and collect all pointy-ear male and female offspring. Your colleague suspects that the two phenotypes may be caused by alleles of one X-linked gene. What sort of cross would you do to determine whether this is an X-linked trait? Name it and describe it. What offspring phenotypic ratio would you expect in that cross if the green allele is a dominant X-linked allele? Make sure to label your ratio with all relevant phenotypes. How would the result of your cross (from A) be different if the trait is autosomalarrow_forwardIn the following cross, imagine that you have a female fly that has two Xs and one Y due to a nondisjunction event in her mother's germ cells. Draw out what the possible gametes are for both the female and the male and also a Punnett square showing the genotypes, phenotypes, and sex of the possible flies as a result of this cross. You do not need to provide the probabilities of each of these. Red-eyed wi C Ở Red-eyed wt XX Y X Y Meiosisarrow_forwardIn fruit flies, red eyes (pr+_) are dominant to purple eyes (prpr) and normal wings (vg+_) are dominant to vestigial wings (vgvg). The genes are located on the same chromosome. A pure-breeding red-eyed fly with vestigial wings was crossed with a pure-breeding purple-eyed fly with normal wings. All of the F1 progeny had a WT phenotype. The recombination frequency between the two genes is 15%. If an F1 individual were test crossed, what percentage of the progeny would you expect to have the WT phenotype?arrow_forward
- In Drosophila, a cross was made between females—all expressing the three X-linked recessive traits scute bristles (sc), sable body (s), and vermilion eyes (v)—and wild-type males. In the F1, all females were wild type, while all males expressed all three mutant traits. The cross was carried to the F2 generation, and 1000 offspring were counted, with the results shown in the following table. Phenotype Offspring sc s v 314 + + + 280 + s v 150 sc + + 156 sc + v 46 + s + 30 sc s + 10 + + v 14 No determination of sex was made in the data. (a) Using proper nomenclature, determine the genotypes of the P1 and F1 parents. (b) Determine the sequence of the three genes and the map distances between them. (c) Are there more or fewer double crossovers than expected? (d) Calculate the coefficient of coincidence. Does it represent positive or negative interference?arrow_forwardIn a cross between a white-eyed female (ww) and a red-eyed male (w+Y), nearly all the progeny were either red-eyed females (w+w) or white-eyed males (wY). However, about 1 in every 2000 F1 flies had an "exceptional phenotype" and was either a white-eyed female or red-eyed male. How did Bridges explain this unexpected result? A) Crossing over B) Incomplete cytokinesis C) Incorrect synapsis D) Nondisjunction E) Pseudoautosomal regionarrow_forwardAssume that the trihybrid cross AABBrr x aabbRR is made in a plant species. Assume that A and B are dominant alleles, but there is no dominance effect of alleles at the R locus. a) How many different gametes are possible in the F1generation? What are the genotypes of these gametes? b) What is the probability of the parental aabbRR genotype in the F2 progeny? c) What proportion of the F2 progeny would be expected to be homozygous for all three genes?arrow_forward
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