Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 23, Problem 1EQ
Is each of the following a method used in linkage, cytogenetic, or physical mapping?
A. Fluorescence in situ hybridization (FISH)
B. Conducting two-factor crosses to compute map distances
C. Chromosome walking
D. Examination of polytene chromosomes in Drosophila
E. Use of RFLPs in crosses
F. Using BACs and cosmids to construct a contig
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Chapter 23 Solutions
Genetics: Analysis and Principles
Ch. 23.1 - Prob. 1COMQCh. 23.2 - Prob. 1COMQCh. 23.3 - A molecular marker is a _____ found at a specific...Ch. 23.3 - 2. Which of the following is an example of a...Ch. 23.3 - To map the distance between molecular markers via...Ch. 23.4 - 1. What is a contig?
a. A fragment of DNA that...Ch. 23.4 - A vector that can carry a large fragment of...Ch. 23.4 - 3. Chromosomal walking is a method of _____ in...Ch. 23.5 - Prob. 1COMQCh. 23.5 - Prob. 2COMQ
Ch. 23.5 - 3. A prokaryotic genome is about 4 million bp in...Ch. 23.6 - Metagenomics is aimed at a. determining the...Ch. 23 - 1. A person with a rare genetic disease has a...Ch. 23 - For each of the following, decide if it could be...Ch. 23 - Which of the following statements about molecular...Ch. 23 - 1. Is each of the following a method used in...Ch. 23 - Prob. 2EQCh. 23 - Prob. 3EQCh. 23 - The cells from a persons malignant tumor were...Ch. 23 - 5. Figure 23.2 describes the technique of FISH....Ch. 23 - Explain how DNA probes with different fluorescence...Ch. 23 - 7. A researcher is interested in a gene found on...Ch. 23 - Prob. 8EQCh. 23 - Prob. 9EQCh. 23 - Prob. 10EQCh. 23 - Prob. 11EQCh. 23 - Prob. 12EQCh. 23 - In the Human Genome Project, researchers have...Ch. 23 - 14. Take a look at question 3 in More Genetic...Ch. 23 - 15. Place the following stages of a physical...Ch. 23 - 16. What is an STS? How are STSs generated...Ch. 23 - 17. Four cosmid clones, which we will call cosmids...Ch. 23 - A human gene, which we will call geneX, is located...Ch. 23 - 19. Describe how you would clone a gene by...Ch. 23 - 20. A bacterium has a genome size of 4.4 Mb. If a...Ch. 23 - 21. Discuss the advantages of next-generation...Ch. 23 - Prob. 22EQCh. 23 - Prob. 23EQCh. 23 - What is a molecular marker? Give two examples....Ch. 23 - Which goals of the Human Genome Project do you...
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- Consider a maize plant: Genotype C/cm ; Ac/Ac+ where cm is an unstable colorless allele caused by Ds insertion. What phenotypic ratios would be produced and in what proportions when this plant is crossed with a mutant c/c Ac+/Ac+? Assume that the Ac and c loci are unlinked, that the chromosome-breakage frequency is negligible, and the C allele encodes pigment production.arrow_forwardEC1. In drosophila the cw (curly wings) gene and eb (ebony body) genes are found on the same chromosome 20 map units apart. A cross was made between an ebony bodied parental strain and a curly winged parental strain and the F1’s were test crossed. a) What are the genotypes of the parental strains? b) What are the genotypes of the F1’s? c) What is the genotype of the tester strain? d) What progeny phenotypes and genotypes do you expect, and in what proportions? For phenotypes use the mutant phenotype for any that the flies have, and wild-type if they have none. EC2. Here is a tetrad produced by mating a H Y strain to an h y strain. a) What is the tetrad type? b) What has recombined with what? EC3. In corn, a dihybrid for the recessive genes a and b is test-crossed. The distribution of the phenotypes is as follows: A B 122A b 118a B 81a b 79 a) Do the genes appear to be sorting independently? Look at map units here. b) Test your hypothesis with a chi-squared test.arrow_forwardn corn, male sterility is controlled by maternal cytoplasmic elements. This phenotype renders the male part of the corn plants (i.e the tassel) unable to produce fertile pollen; the female parts, however, remain receptive to pollination by pollen from male fertile corn plants. However, the presence of a nuclear fertility restorer gene F restores fertility to male sterile lines Using the cardboard chips, simulate the crosses indicated below. Give the genotypes and phenotypes of the offsprings in each cross, and properly label the nucleus and the cytoplasm each individual in the cross Legend male sterile cytoplasm Male fertile cytoplasm FF nucleus Ff nucleus ff nucleus A. Male sterile female x FF male Explain the phenotype of the offspring B. Male sterile female x Ff male Explain the phenotype of the offspringarrow_forward
- A cross between yeast strains ab x AB produces the following unordered tetrads: a. Label each group of tetrads as parental ditypes (PD), non-parental ditypes (NPD), or tetratypes (T). AB AB ab ab 43 6 22 b. Are the genes linked or on separate chromosomes? Why? aB aB Ab Ab Ab AB ab aB c. If the genes are linked determine the distance between them.arrow_forwardGenes Q, R, and S are on the same chromosome. The crossoverfrequency between S and Q is 5%, the crossover frequency betweenQ and R is 30%, and the crossover frequency between R and S is35%. Use this information to create a linkage map for thechromosomearrow_forwardIn corn, male sterility is controlled by maternal cytoplasmic elements. This phenotype renders the male part of the corn plants (i.e the tassel) unable to produce fertile pollen; the female parts, however, remain receptive to pollination by pollen from male fertile corn plants. However, the presence of a nuclear fertility restorer gene F restores fertility to male sterile lines Using the cardboard chips, simulate the crosses indicated below. Give the genotypes and phenotypes of the offsprings in each cross, and properly label the nucleus and the cytoplasm of each individual in the cross Legend male sterile cytoplasm Male fertile cytoplasm FF nucleus Ff nucleus ff nucleus A. Male sterile female x FF male Explain the phenotype of the offspring B. Male sterile female x Ff male Explain the phenotype of the offspringarrow_forward
- For questions 22 through 30, please refer to the pictures below: Normal B B B C D D D D' E E 22 23 24 B D G. Y D M H. B C E 25 26 27 28 B D Break through centromere B B A D 29 30 Identify the type of chromosomal aberration in each number above. Please refer to the choices below. Reciprocal translocation Robertsonian translocation Isochromosome Terminal deletion Interstitial deletion Duplication Pericentric inversion Ring chromosome Marker chromosome Paracentric inversionarrow_forwardSuppose researchers studied the first chromosome of a new species and mapped three genes of interest, indicated as a, b, and c. A three‑factor cross was performed and the number of gametes formed from the F2 generation was recorded in a table. Note that the order of genes in the table is arbitrary. Calculate the recombination frequencies for each given gene pair in map units. a+ b+ c+ a b c a b+ c+ a+ b c a b+ c a+ b c+ a b c+ a+ b+ c 173 176 35 33 11 10 3 1 After completing the gene mapping, the researchers treated individuals to induce inversions in the chromosomes. After treatment, another three‑factor cross was performed and the number of gametes formed from the F2 generation was recorded in a second table. Note that the order of genes in the table is arbitrary. a+ b+ c+ abc a b+ c+ ?+ b c a b+ c a+ b c+ a b c+ a+ b+ c 188 185 24 26 1 0 49 46 Calculate the recombination frequencies for each given gene pair in map units.arrow_forwardConsider two maize plants:a. Genotype C/cm ; Ac/Ac+, where cm is an unstableallele caused by a Ds insertionb. Genotype C/cm, where cm is an unstable allele causedby Ac insertionWhat phenotypes would be produced and in whatproportions when (1) each plant is crossed with a basepair-substitution mutant c/c and (2) the plant in part a iscrossed with the plant in part b? Assume that Ac and care unlinked, that the chromosome-breakage frequencyis negligible, and that mutant c /C is Ac+.arrow_forward
- In the diagram in the box below the horizontal line represents a chromosome and A, B, C, D and E represent the position of genes on the chromosome. You would expect the highest frequency of recombination of genes to occur between? A BC D E Lll S a) Between genes B and D b) Between genes B and C c) Between genes A and B d) Between genes A and Carrow_forwardIn a series of mapping experiments, the recombination frequencies for four different linked genes of the Drosophila fly were determined, as shown in the figure. Based on this information, what is the most probable order of these genes on the chromosome? b 0 cn 90 rb 3.5 6.5 0 vg 19 9.0 16 0 b cn rb vg The numbers in the boxes are the recombination frequencies in between the genes (in percent). O b-rb-cn-vg O vg-cn-b-rb Orb-cn-vg-b b = black body cn = cinnabar eyes rb = reduced bristles vg = vestigial wings O vg-b-rb-cnarrow_forwardA contig map for a chromosome in Drosophila is shown below. The chromosome has 10 segments, numbered 1- 10. Drosophila Chromosome 1 2 4 7 9 10 A Genomic Clones C D E If an EST hybridizes with genomic clones C, D and E, but not with the other clones, in which segment of the chromosome is the EST found? Enter a number. If a clone of gene GLO hybridizes only with genomic clones F and G, in which chromosome segment is gene GLO located? Enter a number. If a restriction fragment hybridizes with only one of the genomic clones, in which chromosome segment(s) could the fragment be found? Enter numbers for each segment ordered from smallest to largest separated by commas and no spaces. (Le. 4.8,10)arrow_forward
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